Items where authors include "Simpson, J.E."

Article

Mistry, H., Richardson, C.D., Higginbottom, A. orcid.org/0000-0002-3246-6695 et al. (7 more authors) (2024) Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort. Neuroscience Research, 204. pp. 22-33. ISSN 0168-0102

Almansouri, T., Waller, R. orcid.org/0000-0001-5815-8829, Wharton, S.B. orcid.org/0000-0003-2785-333X et al. (5 more authors) (2024) The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood–brain barrier dysfunction. International Journal of Molecular Sciences, 25 (8). 4445. ISSN 1422-0067

Floare, M.-L., Wharton, S.B., Simpson, J.E. et al. (3 more authors) (2024) Cerebellar degeneration in gluten ataxia is linked to microglial activation. Brain Communications, 6 (2). fcae078. ISSN 2632-1297

Wharton, S.B. orcid.org/0000-0003-2785-333X, Simpson, J.E. orcid.org/0000-0002-3753-4271, Ince, P.G. et al. (4 more authors) (2023) Insights into the pathological basis of dementia from population based neuropathology studies. Neuropathology and Applied Neurobiology, 49 (4). e12923. ISSN 0305-1846

Waller, R. orcid.org/0000-0001-5815-8829, Hase, Y., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (4 more authors) (2023) Transcriptomic profiling reveals discrete poststroke dementia neuronal and gliovascular signatures. Translational Stroke Research, 14 (3). pp. 383-396. ISSN 1868-601X

Simpson, J.E. orcid.org/0000-0002-3753-4271 (2023) Potential mechanisms underlying the dysfunction of the blood–brain barrier. International Journal of Molecular Sciences, 24 (9). 8184. ISSN 1661-6596

Hase, Y., Ameen‐Ali, K.E., Waller, R. orcid.org/0000-0001-5815-8829 et al. (11 more authors) (2022) Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke. Brain Pathology, 32 (6). e13101. ISSN 1015-6305

Vázquez-Villaseñor, I., Smith, C.I., Thang, Y.J.R. et al. (5 more authors) (2022) RNA-Seq profiling of neutrophil-derived microvesicles in Alzheimer’s disease patients identifies a miRNA signature that may impact blood–brain barrier integrity. International Journal of Molecular Sciences, 23 (11). 5913.

Matuszyk, M.M., Garwood, C.J., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (3 more authors) (2022) Biological and methodological complexities of beta‐amyloid peptide; implications for Alzheimer’s disease research. Journal of Neurochemistry, 160 (4). pp. 434-453. ISSN 0022-3042

Vazquez‐Villasenor, I., Garwood, C.J., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (3 more authors) (2021) Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience, 54 (9). pp. 6987-7005. ISSN 0953-816X

Waller, R. orcid.org/0000-0001-5815-8829, Narramore, R., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (12 more authors) (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer’s and small vessel disease pathologies. Brain Pathology, 31 (3). e12928. ISSN 1015-6305

Ashford, B.A. orcid.org/0000-0002-9247-3125, Boche, D., Cooper‐Knock, J. et al. (3 more authors) (2021) Review: Microglia in motor neuron disease. Neuropathology and Applied Neurobiology, 47 (2). pp. 179-197. ISSN 0305-1846

Bury, J.J., Chambers, A., Heath, P.R. et al. (6 more authors) (2021) Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9 (1). 5.

Fadul, M.M. orcid.org/0000-0002-2208-9988, Heath, P.R., Cooper-Knock, J. orcid.org/0000-0002-0873-8689 et al. (8 more authors) (2020) Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 7924. ISSN 1661-6596

Allen, S.P., Seehra, R.S., Heath, P.R. et al. (6 more authors) (2020) Transcriptomic analysis of human astrocytes in vitro reveals hypoxia-induced mitochondrial dysfunction, modulation of metabolism, and dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 8028. ISSN 1422-0067

Chambers, A., Bury, J.J., Minett, T. et al. (9 more authors) (2020) Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79 (9). pp. 950-958. ISSN 0022-3069

MacGregor Sharp, M., Saito, S., Keable, A. et al. (7 more authors) (2020) Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia. Acta Neuropathologica Communications, 8 (1). 131. ISSN 2051-5960

Waller, R. orcid.org/0000-0001-5815-8829, Mandeya, M., Viney, E. et al. (2 more authors) (2020) Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex. Neuropathology, 40 (4). pp. 336-346. ISSN 0919-6544

Vazquez-Villaseñor, I., Garwood, C.J., Heath, P.R. et al. (3 more authors) (2020) Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease. Neuropathology and Applied Neurobiology, 46 (2). pp. 171-185. ISSN 0305-1846

Fadul, M.M. orcid.org/0000-0002-2208-9988, Garwood, C.J., Waller, R. orcid.org/0000-0001-5815-8829 et al. (6 more authors) (2020) NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21 (1). 340. ISSN 1661-6596

Ajikumar, A., Long, M.B., Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (4 more authors) (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20 (20). 5227. ISSN 1661-6596

Goodall, E.F., Leach, V., Wang, C. et al. (8 more authors) (2019) Age-associated mRNA and miRNA expression changes in the blood-brain barrier. International Journal of Molecular Sciences, 20 (12). 3097. ISSN 1661-6596

Coelho, S., Pozo, J.M., Costantini, M. et al. (5 more authors) (2019) Histological data of axons, astrocytes, and myelin in deep subcortical white matter populations. Data in Brief, 23. 103762. ISSN 2352-3409

López, K.L.R., Simpson, J.E. orcid.org/0000-0002-3753-4271, Watson, L.C. et al. (4 more authors) (2019) TIGAR inclusion pathology is specific for Lewy body diseases. Brain Research, 1706. pp. 218-223. ISSN 0006-8993

Waller, R. orcid.org/0000-0001-5815-8829, Baxter, L., Fillingham, D.J. et al. (7 more authors) (2019) Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions. PLoS One, 14 (1). e0210888. ISSN 1932-6203

Ratcliffe, L.E., Vázquez Villaseñor, I., Jennings, L. et al. (8 more authors) (2018) Loss of IGF1R in human astrocytes alters complex I activity and support for neurons. Neuroscience, 390. pp. 46-59. ISSN 0306-4522

Coelho, S. orcid.org/0000-0002-1039-4803, Pozo, J.M., Costantini, M. et al. (5 more authors) (2018) Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter. NeuroImage, 179. pp. 275-287. ISSN 1053-8119

Morgan, S.V., Garwood, C.J., Jennings, L. et al. (10 more authors) (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47 (12). pp. 1444-1456. ISSN 0953-816X

Goodall, E.F., Wang, C., Simpson, J.E. et al. (6 more authors) (2018) Age-associated changes in the blood brain barrier: Comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44 (3). pp. 328-340. ISSN 0305-1846

Ameen-Ali, K.E., Wharton, S.B., Simpson, J.E. et al. (3 more authors) (2017) Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43 (7). pp. 553-570. ISSN 0305-1846

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2017) Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and Applied Neurobiology, 43 (4). pp. 281-298. ISSN 1365-2990

Tu, W.Y., Simpson, J.E., Highley, J.R. et al. (1 more author) (2017) Spinal muscular atrophy: Factors that modulate motor neurone vulnerability. Neurobiology of Disease, 102. pp. 11-20. ISSN 0969-9961

Waller, R., Woodroofe, M.N., Wharton, S.B. et al. (8 more authors) (2016) Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299. pp. 139-146. ISSN 1872-8421

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2016) Review: Astrocytes in Alzheimer's disease and other age-associated dementias; a supporting player with a central role. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Heath, P.R., Appleby-Mallinder, C., Wyles, M.D. et al. (3 more authors) (2016) Expression microdissection isolation of enriched cell populations from archival brain tissue. Journal of Neuroscience Methods. ISSN 0165-0270

Fluteau, A., Ince, P.G., Minett, T. et al. (10 more authors) (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609. pp. 11-17. ISSN 0304-3940

Al-Mashhadi, S., Simpson, J.E., Heath, P.R. et al. (6 more authors) (2015) Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathology, 25 (5). pp. 565-574. ISSN 1015-6305

Garwood, C.J., Ratcliffe, L.E., Morgan, S.V. et al. (7 more authors) (2015) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8. 51 . ISSN 1756-6606

Simpson, J.E., Ince, P.G., Minett, T. et al. (9 more authors) (2015) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Simpson, J.E., Ince, P.G., Matthews, F.E. et al. (7 more authors) (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41 (4). pp. 483-496. ISSN 0305-1846

Mathur, R., Ince, P.G., Minett, T. et al. (7 more authors) (2015) A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. PLOS ONE, 10 (2). e0118463. ISSN 1932-6203

Asi, Y.T., Simpson, J.E. orcid.org/0000-0002-3753-4271, Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (5 more authors) (2014) Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia, 62 (6). pp. 964-970. ISSN 0894-1491

Highley, J.R. orcid.org/0000-0002-4969-6526, Gebril, O.H., Simpson, J.E. et al. (9 more authors) (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Journal of Aging Science, 2 (1).

Proceedings Paper

Waller, S., Baxter, L., Fillingham, D. et al. (7 more authors) (2019) Iba-1-/CD68+microglia are a prominent feature of age-associated deep subcortical white matter lesions. In: Neuropathology and Applied Neurobiology. 120th Meeting of the British Neuropathological Society, Developmental Neuropathology Symposium, 06-08 Mar 2019, London, UK. Wiley , p. 33.