Current strategies in meniscal regeneration

Abstract

The meniscus plays an important role in the biomechanics and tribology of the knee joint. Damage to or disease of the meniscus is now recognized to predispose to the development of osteoarthritis. Treatment of meniscal injury through arthroscopic surgery has become one of the most common orthopedic surgical procedures, and in the United States this can represent 10 to 20% of procedures related to the knee. The meniscus has a limited healing capacity constrained to the vascularized periphery and therefore, surgical repair of the avascular regions is not always feasible. Replacement and repair of the meniscus to treat injuries is being investigated using tissue engineering strategies. Promising as these approaches may be, there are, however, major barriers to overcome before translation to the clinic.

Metadata

Item Type:	Article
Authors/Creators:	Hasan, J Fisher, J Ingham, E
Copyright, Publisher and Additional Information:	(c) 2013, Wiley Periodicals, Inc. Uploaded in accordance with the publisher's self-archiving policy. This is the accepted version of the following article: Hasan J, Fisher J, Ingham E. 2014. Current strategies in meniscal regeneration. Journal of Biomedical Materials Research Part B. 2014:102B:619–634 which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33030
Keywords:	Meniscus; regenerative medicine; scaffolds; tissue engineering
Dates:	Published: April 2014
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	02 Oct 2014 09:41
Last Modified:	02 Oct 2014 09:41
Published Version:	http://dx.doi.org/10.1002/jbm.b.33030
Status:	Published
Publisher:	Wiley
Identification Number:	10.1002/jbm.b.33030
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:80512