Items where authors include "Wharton, S.B."

Article

Rajab, M.D., Taketa, T., Wharton, S.B. orcid.org/0000-0003-2785-333X et al. (2 more authors) (2024) Ranking and filtering of neuropathology features in the machine learning evaluation of dementia studies. Brain Pathology, 34 (4). e13247. ISSN 1015-6305

Mistry, H., Richardson, C.D., Higginbottom, A. orcid.org/0000-0002-3246-6695 et al. (7 more authors) (2024) Relationships of brain cholesterol and cholesterol biosynthetic enzymes to Alzheimer’s pathology and dementia in the CFAS population-derived neuropathology cohort. Neuroscience Research, 204. pp. 22-33. ISSN 0168-0102

Xia, Z., Prescott, E.E., Urbanek, A. et al. (28 more authors) (2024) Co-aggregation with apolipoprotein E modulates the function of amyloid-β in Alzheimer's disease. Nature Communications, 15. 4695. ISSN 2041-1723

Almansouri, T., Waller, R. orcid.org/0000-0001-5815-8829, Wharton, S.B. orcid.org/0000-0003-2785-333X et al. (5 more authors) (2024) The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood–brain barrier dysfunction. International Journal of Molecular Sciences, 25 (8). 4445. ISSN 1422-0067

Floare, M.-L., Wharton, S.B., Simpson, J.E. et al. (3 more authors) (2024) Cerebellar degeneration in gluten ataxia is linked to microglial activation. Brain Communications, 6 (2). fcae078. ISSN 2632-1297

Wharton, S.B. orcid.org/0000-0003-2785-333X, Simpson, J.E. orcid.org/0000-0002-3753-4271, Ince, P.G. et al. (4 more authors) (2023) Insights into the pathological basis of dementia from population based neuropathology studies. Neuropathology and Applied Neurobiology, 49 (4). e12923. ISSN 0305-1846

Waller, R. orcid.org/0000-0001-5815-8829, Hase, Y., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (4 more authors) (2023) Transcriptomic profiling reveals discrete poststroke dementia neuronal and gliovascular signatures. Translational Stroke Research, 14 (3). pp. 383-396. ISSN 1868-601X

Rajab, M.D., Jammeh, E., Taketa, T. et al. (6 more authors) (2023) Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection. Alzheimer's Research & Therapy, 15. 47. ISSN 1758-9193

Nichols, E., Merrick, R., Hay, S.I. et al. (19 more authors) (2023) The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. The Lancet Healthy Longevity, 4 (3). e115. ISSN 2666-7568

Cooper‐Knock, J., Julian, T.H., Feneberg, E. et al. (15 more authors) (2023) Atypical TDP-43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP. Brain Pathology, 33 (1). e13104. ISSN 1015-6305

Hase, Y., Ameen‐Ali, K.E., Waller, R. orcid.org/0000-0001-5815-8829 et al. (11 more authors) (2022) Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke. Brain Pathology, 32 (6). e13101. ISSN 1015-6305

Nelson, P.T., Brayne, C., Flanagan, M.E. et al. (46 more authors) (2022) Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathologica, 144 (1). pp. 27-44. ISSN 0001-6322

Vázquez-Villaseñor, I., Smith, C.I., Thang, Y.J.R. et al. (5 more authors) (2022) RNA-Seq profiling of neutrophil-derived microvesicles in Alzheimer’s disease patients identifies a miRNA signature that may impact blood–brain barrier integrity. International Journal of Molecular Sciences, 23 (11). 5913.

Matuszyk, M.M., Garwood, C.J., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (3 more authors) (2022) Biological and methodological complexities of beta‐amyloid peptide; implications for Alzheimer’s disease research. Journal of Neurochemistry, 160 (4). pp. 434-453. ISSN 0022-3042

Richardson, S., Hill, R.M., Kui, C. et al. (27 more authors) (2022) Emergence and maintenance of actionable genetic drivers at medulloblastoma relapse. Neuro-Oncology, 24 (1). pp. 153-165. ISSN 1522-8517

Perez-Nievas, B.G., Johnson, L., Beltran-Lobo, P. et al. (10 more authors) (2021) Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity. Journal of Neuroinflammation, 18 (1). 306.

Vazquez‐Villasenor, I., Garwood, C.J., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (3 more authors) (2021) Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience, 54 (9). pp. 6987-7005. ISSN 0953-816X

Ellmerich, S., Taylor, G.W., Richardson, C.D. et al. (7 more authors) (2021) Dementia in the older population is associated with neocortex content of serum amyloid P component. Brain Communications, 3 (4). fcab225.

Crosier, S., Hicks, D., Schwalbe, E.C. et al. (13 more authors) (2021) Advanced molecular pathology for rare tumours: a national feasibility study and model for centralised medulloblastoma diagnostics. Neuropathology and Applied Neurobiology, 47 (6). pp. 736-747. ISSN 0305-1846

Waller, R. orcid.org/0000-0001-5815-8829, Narramore, R., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (12 more authors) (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer’s and small vessel disease pathologies. Brain Pathology, 31 (3). e12928. ISSN 1015-6305

Hicks, D., Rafiee, G., Schwalbe, E.C. et al. (18 more authors) (2021) The molecular landscape and associated clinical experience in infant medulloblastoma : prognostic significance of second‐generation subtypes. Neuropathology and Applied Neurobiology, 47 (2). pp. 236-250. ISSN 0305-1846

Bury, J.J., Chambers, A., Heath, P.R. et al. (6 more authors) (2021) Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9 (1). 5.

Hill, R.M., Richardson, S., Schwalbe, E.C. et al. (13 more authors) (2020) Time, pattern, and outcome of medulloblastoma relapse and their association with tumour biology at diagnosis and therapy: a multicentre cohort study. The Lancet Child & Adolescent Health, 4 (12). pp. 865-874. ISSN 2352-4642

De Marco, M. orcid.org/0000-0002-9240-8067, Manca, R. orcid.org/0000-0003-1715-6442, Kirby, J. orcid.org/0000-0002-7468-5917 et al. (5 more authors) (2020) The association between polygenic hazard and markers of Alzheimer’s disease following stratification for APOE genotype. Current Alzheimer Research, 17 (7). pp. 667-679. ISSN 1567-2050

Fadul, M.M. orcid.org/0000-0002-2208-9988, Heath, P.R., Cooper-Knock, J. orcid.org/0000-0002-0873-8689 et al. (8 more authors) (2020) Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 7924. ISSN 1661-6596

Allen, S.P., Seehra, R.S., Heath, P.R. et al. (6 more authors) (2020) Transcriptomic analysis of human astrocytes in vitro reveals hypoxia-induced mitochondrial dysfunction, modulation of metabolism, and dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 8028. ISSN 1422-0067

Chambers, A., Bury, J.J., Minett, T. et al. (9 more authors) (2020) Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79 (9). pp. 950-958. ISSN 0022-3069

MacGregor Sharp, M., Saito, S., Keable, A. et al. (7 more authors) (2020) Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia. Acta Neuropathologica Communications, 8 (1). 131. ISSN 2051-5960

Waller, R. orcid.org/0000-0001-5815-8829, Mandeya, M., Viney, E. et al. (2 more authors) (2020) Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex. Neuropathology, 40 (4). pp. 336-346. ISSN 0919-6544

Shabir, O. orcid.org/0000-0001-7412-6966, Sharp, P., Rebollar, M.A. et al. (5 more authors) (2020) Enhanced cerebral blood volume under normobaric hyperoxia in the J20-hAPP mouse model of Alzheimer’s disease. Scientific Reports, 10 (1). 7518.

Das, J., Gill, A., Lo, C. et al. (6 more authors) (2020) A case of multiple sclerosis—like relapsing remitting encephalomyelitis following allogeneic hematopoietic stem cell transplantation and a review of the published literature. Frontiers in Immunology, 11. 668.

Vazquez-Villaseñor, I., Garwood, C.J., Heath, P.R. et al. (3 more authors) (2020) Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease. Neuropathology and Applied Neurobiology, 46 (2). pp. 171-185. ISSN 0305-1846

Richardson, K., Wharton, S.B. orcid.org/0000-0003-2785-333X, Grossi, C.M. et al. (12 more authors) (2020) Neuropathological correlates of cumulative benzodiazepine and anticholinergic drug use. Journal of Alzheimer's Disease, 74 (3). pp. 999-1009. ISSN 1387-2877

Fadul, M.M. orcid.org/0000-0002-2208-9988, Garwood, C.J., Waller, R. orcid.org/0000-0001-5815-8829 et al. (6 more authors) (2020) NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21 (1). 340. ISSN 1661-6596

Wharton, S.B., Wang, D. orcid.org/0000-0003-0068-1005, Parikh, C. et al. (3 more authors) (2019) Epidemiological pathology of Aβ deposition in the ageing brain in CFAS : addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches. Acta Neuropathologica Communications, 7 (1). 198. pp. 1-12.

Ajikumar, A., Long, M.B., Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (4 more authors) (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20 (20). 5227. ISSN 1661-6596

Wharton, S.B., Verber, N.S., Wagner, B.E. et al. (6 more authors) (2019) Combined FUS+ basophilic inclusion body disease and atypical tauopathy presenting with an ALS/MND-plus phenotype. Neuropathology and Applied Neurobiology, 45 (6). pp. 586-596. ISSN 0305-1846

Goodall, E.F., Leach, V., Wang, C. et al. (8 more authors) (2019) Age-associated mRNA and miRNA expression changes in the blood-brain barrier. International Journal of Molecular Sciences, 20 (12). 3097. ISSN 1661-6596

Mills, M.T. orcid.org/0000-0002-5425-7739, Wharton, S.B., Connolly, D.J. et al. (2 more authors) (2018) Pituitary apoplexy secondary to metastatic breast carcinoma into a gonadotroph cell adenoma of the pituitary. British Journal of Neurosurgery, 36 (5). pp. 643-646. ISSN 0268-8697

Ratcliffe, L.E., Vázquez Villaseñor, I., Jennings, L. et al. (8 more authors) (2018) Loss of IGF1R in human astrocytes alters complex I activity and support for neurons. Neuroscience, 390. pp. 46-59. ISSN 0306-4522

Morgan, S.V., Garwood, C.J., Jennings, L. et al. (10 more authors) (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47 (12). pp. 1444-1456. ISSN 0953-816X

Goodall, E.F., Wang, C., Simpson, J.E. et al. (6 more authors) (2018) Age-associated changes in the blood brain barrier: Comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44 (3). pp. 328-340. ISSN 0305-1846

Ameen-Ali, K.E., Wharton, S.B., Simpson, J.E. et al. (3 more authors) (2017) Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43 (7). pp. 553-570. ISSN 0305-1846

Ince, P.G., Minett, T., Forster, G. et al. (3 more authors) (2017) Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease. Neuropathology and Applied Neurobiology, 43 (5). pp. 409-418. ISSN 0305-1846

Kovacs, G.G., Xie, S.X., Lee, E.B. et al. (59 more authors) (2017) Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology, 76 (7). pp. 605-619. ISSN 0022-3069

Schwalbe, E.C., Lindsey, J.C., Nakjang, S. et al. (15 more authors) (2017) Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study. Lancet Oncology , 18 (7). pp. 958-971. ISSN 1470-2045

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2017) Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and Applied Neurobiology, 43 (4). pp. 281-298. ISSN 1365-2990

Bagga, V., Kailaya-Vasan, A., Wharton, S.B. et al. (1 more author) (2017) Intracerebral Masson's Tumor—Slow-Filling Vascular Lesion Demonstrated by Indocyanine Green Video Angiography. World Neurosurgery , 101. 812.e15-812.e19. ISSN 1878-8750

Larsen, J., Wharton, S.B., Romanowski, C. et al. (4 more authors) (2017) Low grade glioma: An Update for Radiologists. British Journal of Radiology, 90 (1070). 20160600. ISSN 0007-1285

Waller, R., Woodroofe, M.N., Wharton, S.B. et al. (8 more authors) (2016) Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299. pp. 139-146. ISSN 1872-8421

McAleese, K.E., Alafuzoff, I., Charidimou, A. et al. (18 more authors) (2016) Post-mortem assessment in vascular dementia: advances and aspirations. BMC Medicine, 14 (1). p. 129. ISSN 1741-7015

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2016) Review: Astrocytes in Alzheimer's disease and other age-associated dementias; a supporting player with a central role. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Heath, P.R., Appleby-Mallinder, C., Wyles, M.D. et al. (3 more authors) (2016) Expression microdissection isolation of enriched cell populations from archival brain tissue. Journal of Neuroscience Methods. ISSN 0165-0270

Matthews, F.E., Stephan, B.C.M., Robinson, L. et al. (22 more authors) (2016) A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nature Communications, 7. 11398. p. 11398. ISSN 2041-1723

Wharton, S.B., Minett, T., Drew, D. et al. (5 more authors) (2016) Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study. Acta Neuropathol Communications, 4. 11. ISSN 2051-5960

Kovacs, G.G., Ferrer, I., Grinberg, L.T. et al. (69 more authors) (2016) Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica, 131 (1). pp. 87-102. ISSN 0001-6322,

Fluteau, A., Ince, P.G., Minett, T. et al. (10 more authors) (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609. pp. 11-17. ISSN 0304-3940

Al-Mashhadi, S., Simpson, J.E., Heath, P.R. et al. (6 more authors) (2015) Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathology, 25 (5). pp. 565-574. ISSN 1015-6305

Garwood, C.J., Ratcliffe, L.E., Morgan, S.V. et al. (7 more authors) (2015) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8. 51 . ISSN 1756-6606

Simpson, J.E., Ince, P.G., Minett, T. et al. (9 more authors) (2015) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Cooper-Knock, J., Higginbottom, A., Stopford, M.J. et al. (7 more authors) (2015) Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta Neuropathologica, 130 (1). pp. 63-75. ISSN 0001-6322

Highley, J.R., Lorente Pons, A., Cooper-Knock, J. et al. (5 more authors) (2015) Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Simpson, J.E., Ince, P.G., Matthews, F.E. et al. (7 more authors) (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41 (4). pp. 483-496. ISSN 0305-1846

Mathur, R., Ince, P.G., Minett, T. et al. (7 more authors) (2015) A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. PLOS ONE, 10 (2). e0118463. ISSN 1932-6203

Gopal-Kothandapani, J.S., Bagga, V., Wharton, S.B. et al. (3 more authors) (2015) Xanthogranulomatous hypophysitis: a rare and often mistaken pituitary lesion. Endocrinology, Diabetes & Metabolism Case Reports, 2015. 140089.

Beer, A.M., Cooper-Knock, J., Higginbottom, A. et al. (8 more authors) (2014) Intermediate length C9orf72 expansion in an ALS patient without classical C9orf72 neuropathology. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16 (3-4). pp. 249-251. ISSN 2167-8421

Asi, Y.T., Simpson, J.E. orcid.org/0000-0002-3753-4271, Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (5 more authors) (2014) Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia, 62 (6). pp. 964-970. ISSN 0894-1491

Cooper-Knock, J., Walsh, M.J., Higginbottom, A. et al. (9 more authors) (2014) Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. Brain, 137. 2040 - 2051. ISSN 0006-8950

Highley, J.R. orcid.org/0000-0002-4969-6526, Gebril, O.H., Simpson, J.E. et al. (9 more authors) (2014) Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain. Journal of Aging Science, 2 (1).

Richardson, K., Allen, S.P., Mortiboys, H.J. et al. (5 more authors) (2013) The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type. PLoS ONE, 8 (6). e68256. ISSN 1932-6203

Brockington, A., Ning, K., Heath, P.R. et al. (7 more authors) (2013) Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity. Acta Neuropathologica, 125 (1). pp. 95-109. ISSN 0001-6322

Kirby, J., Ning, K., Ferraiuolo, L. et al. (10 more authors) (2011) Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain, 134 (2). pp. 506-517. ISSN 0006-8950

Kirby, J., Goodall, E.F., Smith, W. et al. (10 more authors) (2010) Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis. Neurogenetics, 11 (2). pp. 217-225. ISSN 1364-6745

Cox, L.E., Ferraiuolo, L., Goodall, E.F. et al. (13 more authors) (2010) Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). Plos One, 5 (3). Art no.e9872. ISSN 1932-6203

Matthew, F.E., Brayne, C., Lowe, J. et al. (3 more authors) (2009) Epidemiological pathology of dementia: attributable-risks at death in the medical research council cognitive function and ageing study. PLOS Medicine , 6 (11). Art no.e1000180 . ISSN 1549-1277

Alafuzoff, I., Arzberger, T., Al-Sarraj, S. et al. (27 more authors) (2008) Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe consortium. Brain Pathology, 18 (4). pp. 484-496. ISSN 1015-6305

Wharton, S.B., Hibberd, S., Eward, K.L. et al. (5 more authors) (2004) DNA replication licensing and cell cycle kinetics of oligodendroglial tumours. British Journal of Cancer, 91 (2). pp. 262-269. ISSN 0007-0920