Chandler, JH orcid.org/0000-0001-9232-4966, Hood, A, Culmer, PR orcid.org/0000-0003-2867-0420 et al. (2 more authors) (2014) Technological assessment of the biogalvanic method for tissue characterization. Physiological Measurement, 35 (2). pp. 297-308. ISSN 0967-3334
Abstract
Biogalvanic cells have the potential to be used in characterizing biological tissue properties and ultimately tissue health. A biogalvanic cell is established by placing two differing metal electrodes across a target tissue allowing an electrical tissue-specific internal resistance to be determined. A novel data analysis method using least-squares fitting has been developed to more effectively determine the parameters of the biogalvanic system model proposed in the literature. The validity of the method has been examined through characterization of electrical models, ex vivo porcine tissue, and in vivo porcine tissue. Strong agreement between test results and the proposed characterization model has been shown. However, determined internal resistances are influenced by mechanical strain, current modulation direction and tissue thickness, indicating complexities at the electrode–tissue interface. These complexities undermine some assumptions upon which the biogalvanic model is based. Ultimately this technique could offer potential for use in minimally invasive surgery for discriminating tissue health but requires improved understanding and control of testing conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Institute of Physics and Engineering in Medicine. This is an author produced version of a paper published in Physiological Measurement. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Animals; Colon; Electrodes; Electrophysiology; Liver; Models, Theoretical; Swine |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Robotics, Autonomous Systems & Sensing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Systems and Design (iESD) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Functional Surfaces (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Oct 2015 11:15 |
Last Modified: | 27 Oct 2020 16:36 |
Published Version: | http://dx.doi.org/10.1088/0967-3334/35/2/297 |
Status: | Published |
Publisher: | IOP |
Identification Number: | 10.1088/0967-3334/35/2/297 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87933 |