Mancuso, E orcid.org/0000-0003-1742-1656, Downey, C orcid.org/0000-0001-9818-8002, Doxford-Hook, E et al. (2 more authors) (2020) The use of polymeric meshes for Pelvic Organ Prolapse: current concepts, challenges and future perspectives. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 108 (3). pp. 771-789. ISSN 1552-4973
Abstract
Pelvic organ prolapse (POP) is one of the most common chronic disorders in women, impacting the quality of life of millions of them worldwide. More than 100 surgical procedures have been developed over the decades to treat POP. However, the failure of conservative strategies and the number of patients with recurrence risk have increased the need for further adjuvant treatments. Since their introduction, surgical synthetic meshes have dramatically transformed POP repair showing superior anatomic outcomes in comparison to traditional approaches. Although significant progress has been attained, among the meshes in clinical use, there is no single mesh appropriate for every surgery. Furthermore, due to the risk of complications including acute and chronic infection, mesh shrinkage, and erosion of the tissue, the benefits of the use of meshes have recently been questioned. The aim of this work is to review the evolution of POP surgery, analyzing the current challenges, and detailing the key factors pertinent to the design of new mesh systems. Starting with a description of the pelvic floor anatomy, the article then presents the traditional treatments used in pelvic organ disorders. Next, the development of synthetic meshes is described with an insight into how their function is dependent on both mesh design variables (i.e., material, structure, and functional treatment) and surgical applications. These are then linked to common mesh‐related complications, and an indication of current research aiming to address these issues.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Mancuso, E , Downey, C , Doxford-Hook, E et al. (2019) The use of polymeric meshes for Pelvic Organ Prolapse: current concepts, challenges and future perspectives. Journal of Biomedical Materials Research - Part B Applied Biomaterials. ISSN 1552-4973, which has been published in final form at https://doi.org/10.1002/jbm.b.34432. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | electrospun fibers; pelvic organ prolapse; polymers; synthetic surgical meshes; tissue engineering |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Systems and Design (iESD) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Functional Surfaces (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/N027345/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jun 2019 12:06 |
Last Modified: | 30 Jun 2020 14:49 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/jbm.b.34432 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:147644 |