Items where authors include "Quirke, P"
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Niehues, JM, Quirke, P orcid.org/0000-0002-3597-5444, West, NP orcid.org/0000-0002-0346-6709 et al. (16 more authors) (2023) Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study. Cell Reports Medicine, 4 (4). 100980. ISSN 2666-3791
Ueno, H, Nagtegaal, ID, Quirke, P orcid.org/0000-0002-3597-5444 et al. (2 more authors) (2023) Tumor deposits in colorectal cancer: Refining their definition in the TNM system. Annals of Gastroenterological Surgery, 7 (2). pp. 225-235. ISSN 2475-0328
Bose, M, Wood, HM orcid.org/0000-0003-3009-5904, Young, C orcid.org/0000-0001-5709-4413 et al. (3 more authors) (2023) Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts. BMC Microbiology, 23. 52. ISSN 1471-2180
Gilbert, A orcid.org/0000-0002-9142-1227, Homer, V, Brock, K et al. (18 more authors) (2022) Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision. The Lancet Healthy Longevity, 3 (12). e825-e838. ISSN 2666-7568
Lincoln, A, Benton, S, Piggott, C et al. (6 more authors) (2022) Exploring the utility and acceptability of Faecal immunochemical testing (FIT) as a novel intervention for the improvement of colorectal Cancer (CRC) surveillance in individuals with lynch syndrome (FIT for lynch study): a single-arm, prospective, multi-centre, non-randomised study. BMC Cancer, 22 (1). 1144. ISSN 1471-2407
Taylor, JC orcid.org/0000-0002-2518-5799, Iversen, LH, Burke, D orcid.org/0000-0002-4342-7464 et al. (5 more authors) (2022) Differences in the management of patients requiring an emergency resection for colonic cancer in two European populations. BJS Open, 6 (5). zrac126. ISSN 2474-9842
Birch, RJ orcid.org/0000-0003-1579-1397, Peckham, D orcid.org/0000-0001-7723-1868, Wood, HM orcid.org/0000-0003-3009-5904 et al. (7 more authors) (2022) The risk of colorectal cancer in individuals with mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene: An English population-based study. Journal of Cystic Fibrosis. ISSN 1569-1993
Seiler, C, Stainthorp, AK orcid.org/0000-0001-9561-0095, Ketchen, S et al. (4 more authors) (2022) The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation. Communications Biology, 5 (1). 1029. ISSN 2399-3642
Saldanha, OL, Quirke, P orcid.org/0000-0002-3597-5444, West, NP orcid.org/0000-0002-0346-6709 et al. (24 more authors) (2022) Swarm learning for decentralized artificial intelligence in cancer histopathology. Nature Medicine, 28. pp. 1232-1239. ISSN 1078-8956
Brown, LC, Graham, J, Fisher, D et al. (15 more authors) (2022) Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer. Clinical Trials, 19 (2). pp. 146-157. ISSN 1740-7745
West, N orcid.org/0000-0002-0346-6709, Echle, A, Laleh, NG et al. (35 more authors) (2022) Artificial intelligence for detection of microsatellite instability in colorectal cancer – a multicentric analysis of a pre-screening tool for clinical application. ESMO Open, 7 (2). ISSN 2059-7029
Richman, SD orcid.org/0000-0003-3993-5041, Hemmings, G, Roberts, H et al. (12 more authors) (2022) FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing. Journal of Clinical Pathology. ISSN 0021-9746
Schrammen, PL, Laleh, NG, Echle, A et al. (16 more authors) (2022) Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology. Journal of Pathology, 256 (1). pp. 50-60. ISSN 0022-3417
Taylor, JC orcid.org/0000-0002-2518-5799, Iversen, LH, Burke, D orcid.org/0000-0002-4342-7464 et al. (7 more authors) (2021) Influence of age on surgical treatment and postoperative outcomes of patients with colorectal cancer in Denmark and Yorkshire, England. Colorectal Disease, 23 (12). pp. 3152-3161. ISSN 1462-8910
Echle, A, Laleh, NG, Schrammen, PL et al. (9 more authors) (2021) Deep Learning for the detection of microsatellite instability from histology images in colorectal cancer: a systematic literature review. ImmunoInformatics, 3-4. 100008. ISSN 2667-1190
Seligmann, JF, Fisher, DJ, Brown, LC et al. (19 more authors) (2021) Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring. Journal of Clinical Oncology, 39 (33). pp. 3705-3715. ISSN 0732-183X
Muti, HS, Heij, LR, Keller, G et al. (32 more authors) (2021) Development and validation of deep learning classifiers to detect Epstein-Barr virus and microsatellite instability status in gastric cancer: a retrospective multicentre cohort study. The Lancet Digital Health, 3 (10). e654-e664. ISSN 2589-7500
Adams, RA, Fisher, DJ, Graham, J et al. (19 more authors) (2021) Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial. Journal of Clinical Oncology. JCO.21.01436-JCO.21.01436. ISSN 0732-183X
Fateen, W, Johnson, PJ, Wood, HM orcid.org/0000-0003-3009-5904 et al. (6 more authors) (2021) Characterisation of dysplastic liver nodules using low-pass DNA sequencing and detection of chromosome arm-level abnormalities in blood-derived cell-free DNA. The Journal of pathology, 255 (1). pp. 30-40. ISSN 0022-3417
Hoorn, ST, Sommeijer, DW, Elliot, F et al. (12 more authors) (2021) Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone. British Journal of Cancer. ISSN 0007-0920
Seppälä, TT, Latchford, A, Negoi, I et al. (16 more authors) (2021) European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender. British Journal of Surgery, 108 (5). pp. 484-498. ISSN 0007-1323
Nana, G, Mitra, S orcid.org/0000-0002-9378-1496, Watson, H et al. (8 more authors) (2021) Luminal Bioavailability of Orally Administered ω-3 PUFAs in the Distal Small Intestine, and Associated Changes to the Ileal Microbiome, in Humans with a Temporary Ileostomy. The Journal of nutrition. nxab113. ISSN 0022-3166
Krause, J, Grabsch, HI orcid.org/0000-0001-9520-6228, Kloor, M et al. (13 more authors) (2021) Deep learning detects genetic alterations in cancer histology generated by adversarial networks. The Journal of Pathology, 254 (1). pp. 70-79. ISSN 0022-3417
West, NP orcid.org/0000-0002-0346-6709, Gallop, N, Kaye, D et al. (8 more authors) (2021) Lynch syndrome screening in colorectal cancer: results of a prospective 2-year regional programme validating the NICE diagnostics guidance pathway throughout a 5.2-million population. Histopathology. ISSN 0309-0167
Young, C orcid.org/0000-0001-5709-4413, Wood, HM orcid.org/0000-0003-3009-5904, Fuentes Balaguer, A et al. (13 more authors) (2021) Microbiome Analysis of More Than 2,000 NHS Bowel Cancer Screening Programme Samples Shows the Potential to Improve Screening Accuracy. Clinical Cancer Research, 27 (8). pp. 2246-2254. ISSN 1078-0432
Sirinukunwattana, K, Domingo, E, Richman, SD orcid.org/0000-0003-3993-5041 et al. (21 more authors) (2021) Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning. Gut, 70. pp. 544-554. ISSN 0017-5749
Young, C orcid.org/0000-0001-5709-4413, Wood, HM orcid.org/0000-0003-3009-5904, Seshadri, RA et al. (13 more authors) (2021) The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries. Genome Medicine, 13. 27. ISSN 1756-994X
Taylor, JC orcid.org/0000-0002-2518-5799, Swinson, D, Seligmann, JF et al. (8 more authors) (2021) Addressing the variation in adjuvant chemotherapy treatment for colorectal cancer: can a regional intervention promote national change? International Journal of Cancer, 148 (4). pp. 845-856. ISSN 0020-7136
Bach, SP, Gilbert, A orcid.org/0000-0002-9142-1227, Brock, K et al. (21 more authors) (2021) Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study. The Lancet Gastroenterology & Hepatology, 6 (2). pp. 92-105. ISSN 2468-1253
Bach, SP, Gilbert, A orcid.org/0000-0002-9142-1227, Brock, K et al. (20 more authors) (2021) Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study. The Lancet Gastroenterology and Hepatology, 6 (2). pp. 92-105. ISSN 2468-1253
Malla, SB, Fisher, DJ, Domingo, E et al. (29 more authors) (2020) In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer. Clinical Cancer Research. ISSN 1078-0432
Craig, SG, Humphries, MP, Alderdice, M et al. (21 more authors) (2020) Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia. British Journal of Cancer, 123. pp. 1280-1288. ISSN 0007-0920
Argiles, G, Tabernero, J, Labianca, R et al. (10 more authors) (2020) Localised Colon Cancer: ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up. Annals of Oncology, 31 (10). pp. 1291-1305. ISSN 0923-7534
Echle, A, Grabsch, HI orcid.org/0000-0001-9520-6228, Quirke, P orcid.org/0000-0002-3597-5444 et al. (20 more authors) (2020) Clinical-grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159 (4). 1406-1416.e11. ISSN 0016-5085
Pulsawatdi, AV, Craig, SG, Bingham, V et al. (10 more authors) (2020) A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment. Molecular Oncology, 14 (10). pp. 2384-2402. ISSN 1574-7891
D'Souza, N, Lord, A, Shaw, A et al. (11 more authors) (2020) The sigmoid take-off: An anatomical imaging definition of the rectum validated on specimen analysis. European Journal of Surgical Oncology, 46 (9). pp. 1668-1672. ISSN 0748-7983
Seligmann, JF, Elliott, F, Richman, S orcid.org/0000-0003-3993-5041 et al. (8 more authors) (2020) Clinical and molecular characteristics and treatment outcomes of advanced right-colon, left-colon and rectal cancers: data from 1180 patients in a phase III trial of panitumumab with an extended biomarker panel. Annals of Oncology, 31 (8). pp. 1021-1029. ISSN 0923-7534
Fokas, E, Glynne-Jones, R, Appelt, A orcid.org/0000-0003-2792-9218 et al. (13 more authors) (2020) Outcome measures in multimodal rectal cancer trials. Lancet Oncology, 21 (5). e252-e264. ISSN 1470-2045
Ng, K-S, West, NP orcid.org/0000-0002-0346-6709, Scott, N et al. (3 more authors) (2020) What factors determine specimen quality in colon cancer surgery? A cohort study. International Journal of Colorectal Disease, 35 (5). pp. 869-880. ISSN 0179-1958
Kraima, AC, West, NP orcid.org/0000-0002-0346-6709, Roberts, N et al. (6 more authors) (2020) The role of the longitudinal muscle in the anal sphincter complex: Implications for the Intersphincteric Plane in Low Rectal Cancer Surgery? Clinical Anatomy, 33 (4). pp. 567-577. ISSN 0897-3806
Pleguezuelos-Manzano, C, Puschhof, J, Rosendahl Huber, A et al. (25 more authors) (2020) Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli. Nature, 580 (7802). pp. 269-273. ISSN 0028-0836
D'Souza, N, Lord, AC, Shaw, A et al. (12 more authors) (2020) Ex-vivo specimen MRI and pathology confirm a recto-sigmoid mesenteric waist at the junction of the mesorectum and mesocolon. Colorectal Disease, 22 (2). pp. 212-218. ISSN 1462-8910
Taylor, J orcid.org/0000-0002-2518-5799, Wright, P orcid.org/0000-0001-6129-4143, Rossington, H et al. (5 more authors) (2019) A regional multidisciplinary team intervention programme to improve colorectal cancer outcomes: study protocol for the Yorkshire Cancer Research Bowel Cancer Improvement Programme (YCR BCIP). BMJ Open, 9 (11). e030618. ISSN 2044-6055
Brown, PJ, Rossington, H orcid.org/0000-0002-4570-2730, Taylor, J orcid.org/0000-0002-2518-5799 et al. (5 more authors) (2019) Standardised reports with a template format are superior to free text reports: the case for rectal cancer reporting in clinical practice. European Radiology, 29 (9). pp. 5121-5128. ISSN 0938-7994
Barrow, P, Richman, SD orcid.org/0000-0003-3993-5041, Wallace, A et al. (8 more authors) (2019) Confirmation that somatic mutations of beta-2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial. Histopathology, 75 (2). pp. 236-246. ISSN 0309-0167
Brown, PJ, Rossington, H, Taylor, J et al. (6 more authors) (2019) Radiologist and multidisciplinary team clinician opinions on the quality of MRI rectal cancer staging reports: how are we doing? Clinical Radiology, 74 (8). pp. 637-642. ISSN 0009-9260
Westwood, A, Glover, A, Hutchins, G et al. (9 more authors) (2019) Additional loss of MSH2 and MSH6 expression in sporadic deficient mismatch repair colorectal cancer due to MLH1 promoter hypermethylation. Journal of Clinical Pathology, 72 (6). pp. 443-447. ISSN 0021-9746
Glynne-Jones, R, Hall, MR, Lopes, A et al. (15 more authors) (2018) BACCHUS: A randomised non-comparative phase II study of neoadjuvant chemotherapy (NACT) in patients with locally advanced rectal cancer (LARC). Heliyon, 4 (9). e00804. ISSN 2405-8440
Gollins, S, West, N orcid.org/0000-0002-0346-6709, Sebag-Montefiore, D orcid.org/0000-0002-5978-9259 et al. (11 more authors) (2018) A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS. British Journal of Cancer, 119 (6). pp. 697-706. ISSN 0007-0920
Armstrong, G, Croft, J orcid.org/0000-0001-7586-3394, Corrigan, N et al. (11 more authors) (2018) IntAct: intra‐operative fluorescence angiography to prevent anastomotic leak in rectal cancer surgery: a randomized controlled trial. Colorectal Disease, 20 (8). O226-O234. ISSN 1462-8910
Shutkever, O, Gracie, DJ orcid.org/0000-0001-9616-981X, Young, C et al. (5 more authors) (2018) No Significant Association Between the Fecal Microbiome and the Presence of Irritable Bowel Syndrome-type Symptoms in Patients with Quiescent Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 24 (7). pp. 1597-1605. ISSN 1078-0998
Nicholson, AM, Olpe, C, Hoyle, A et al. (17 more authors) (2018) Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium. Cell Stem Cell, 22 (6). 909-918.e8. ISSN 1934-5909
West, NP orcid.org/0000-0002-0346-6709 and Quirke, P orcid.org/0000-0002-3597-5444 (2018) Colon cancer surgery: pathological quality control is essential for optimal outcomes. Colorectal Disease, 20 (S1). pp. 34-35. ISSN 1462-8910
Seligmann, JF, Hatch, AJ, Richman, SD orcid.org/0000-0003-3993-5041 et al. (8 more authors) (2018) Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer. JAMA Oncology, 4 (4). pp. 564-568. ISSN 2374-2437
Adams, R, Brown, E, Brown, L et al. (14 more authors) (2018) Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2–3 randomised trial. Lancet Gastroenterology and Hepatology, 3 (3). pp. 162-171. ISSN 2468-1253
Adamina, M, Buchs, NC, Penna, M et al. (38 more authors) (2018) St.Gallen consensus on safe implementation of transanal total mesorectal excision. Surgical Endoscopy, 32 (3). pp. 1091-1103. ISSN 0930-2794
Hutchins, GGA orcid.org/0000-0002-1707-4415, Treanor, D orcid.org/0000-0002-4579-484X, Wright, A et al. (9 more authors) (2018) Intra-tumoural stromal morphometry predicts disease recurrence but not response to 5-fluorouracil – results from the QUASAR trial of colorectal cancer. Histopathology, 72 (3). pp. 391-404. ISSN 0309-0167
Sheehan-Dare, GE, Marks, KM, Tinkler-Hundal, E et al. (4 more authors) (2018) The Effect of a Multidisciplinary Regional Educational Programme on the Quality of Colon Cancer Resection. Colorectal Disease, 20 (2). pp. 105-115. ISSN 1462-8910
Stelzner, S, Bottner, M, Kupsch, J et al. (5 more authors) (2018) Internal anal sphincter nerves – a macroanatomical and microscopic description of the extrinsic autonomic nerve supply of the internal anal sphincter. Colorectal Disease, 20 (1). O7-O16. ISSN 1462-8910
Marks, KM, West, NP orcid.org/0000-0002-0346-6709, Morris, E orcid.org/0000-0002-1075-6544 et al. (1 more author) (2018) Clinicopathological, genomic and immunological factors in colorectal cancer prognosis. British Journal of Surgery, 105 (2). e99-e109. ISSN 0007-1323
Rombouts, A, Al-Najami, I, Abbott, N et al. (22 more authors) (2017) Can we Save the rectum by watchful waiting or TransAnal microsurgery following (chemo) Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study. BMJ: British Medical Journal, 7 (12). ISSN 2044-6055
Battersby, NJ, Moran, B, Stelzner, S et al. (11 more authors) (2017) Reply to: Does MRI Restaging of Rectal Cancer After Chemoradiotherapy Actually Permit a Change in Surgical Management? Annals of Surgery, 266 (6). e116-e118. ISSN 0003-4932
Jayne, D orcid.org/0000-0002-8725-3283, Pigazzi, A, Marshall, H orcid.org/0000-0003-0944-0152 et al. (13 more authors) (2017) Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial. Journal of the American Medical Association, 318 (16). pp. 1569-1580. ISSN 0098-7484
Gollins, S, West, N orcid.org/0000-0002-0346-6709, Sebag-Montefiore, D et al. (17 more authors) (2017) Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations. British Journal of Cancer, 117. pp. 1286-1294. ISSN 0007-0920
Watson, H, Mitra, S orcid.org/0000-0002-9378-1496, Croden, FC et al. (10 more authors) (2017) A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut, 67 (11). pp. 1974-1983. ISSN 0017-5749
Bosch, LJW, Trooskens, G, Snaebjornsson, P et al. (21 more authors) (2017) Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer. Oncotarget, 8 (38). pp. 63140-63154. ISSN 1949-2553
Battersby, NJ, Dattani, M, Rao, S et al. (17 more authors) (2017) A Rectal Cancer Feasibility Study with an Embedded Phase III Trial Design Assessing Magnetic Resonance Tumour Regression Grade (mrTRG) as a Novel Biomarker to Stratify Management by Good And Poor Response to Chemoradiotherapy (TRIGGER): study protocol for a randomized controlled trial. Trials, 18. p. 394. ISSN 1745-6215
Taylor, M, Wood, HM orcid.org/0000-0003-3009-5904, Halloran, SP et al. (1 more author) (2017) Examining the potential use and long term stability of guaiac faecal occult blood test cards for microbial DNA 16srRNA sequencing. Journal of Clinical Pathology, 70 (7). pp. 600-606. ISSN 0021-9746
Langman, G, Loughrey, M, Shepherd, N et al. (1 more author) (2017) Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) ‐ Pathology Standards and Datasets. Colorectal Disease, 19 (S1). pp. 74-81. ISSN 1462-8910
Lugli, A, Kirsch, R, Ajioka, Y et al. (21 more authors) (2017) Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Modern Pathology, 30. pp. 1299-1311. ISSN 0893-3952
Nagtegaal, ID, Knijn, N, Hugen, N et al. (5 more authors) (2017) Tumor deposits in colorectal cancer: improving the value of modern staging - a systematic review and meta-analysis. Journal of Clinical Oncology, 35 (10). pp. 1119-1127. ISSN 0732-183X
Wood, HM orcid.org/0000-0003-3009-5904, Foster, JM, Taylor, M et al. (7 more authors) (2017) Comparing mutation calls in fixed tumour samples between the Affymetrix OncoScan® Array and PCR based next-generation sequencing. BMC Medical Genomics, 10. 17.
Seligmann, JF, Fisher, D, Smith, CG et al. (9 more authors) (2017) Investigating the poor outcomes of BRAF - mutant advanced colorectal cancer: Analysis from 2530 patients in randomised clinical trials. Annals of Oncology, 28 (3). pp. 562-568. ISSN 0923-7534
Griggs, RKL, Novelli, MR, Sanders, DSA et al. (4 more authors) (2017) Challenging diagnostic issues in adenomatous polyps with epithelial misplacement in bowel cancer screening: five years' experience of the BCSP Expert Board. Histopathology, 70 (3). pp. 466-472. ISSN 0309-0167
Young, C orcid.org/0000-0001-5709-4413 and Quirke, P orcid.org/0000-0002-3597-5444 (2016) The potential of the microbiome for colorectal cancer screening. Clinical Laboratory International, 40 (Dec 2016 / Jan 2017). pp. 14-17. ISSN 1373-1580
Schoon, J, Brock, IW, Cox, A et al. (7 more authors) (2016) The effect of single nucleotide polymorphisms on clinical outcome and survival in the FOCUS (fluorouracil, oxaliplatin and irinotecan: use and sequencing) clinical trial of metastatic colorectal cancer. Anticancer Research, 36 (12). ABSTR055. pp. 6717-6718. ISSN 0250-7005
Harris, DA, Thorne, K, Hutchings, H et al. (16 more authors) (2016) Protocol for a multicentre randomised feasibility trial evaluating early Surgery Alone In LOw Rectal cancer (SAILOR). BMJ Open, 6 (11). e012496. ISSN 2044-6055
Aravani, A, Samy, EF, Thomas, JD et al. (3 more authors) (2016) A retrospective observational study of length of stay in hospital after colorectal cancer surgery in England (1998-2010). Medicine, 95 (47). ISSN 0025-7974
Glimelius, B, Hohenberger, WM, Matzel, KE et al. (2 more authors) (2016) Reply to D.J. Sargent et al. Journal of Clinical Oncology, 34 (30). pp. 3713-3714. ISSN 0732-183X
Munkedal, DLE, Laurberg, S, Hagemann-Madsen, R et al. (4 more authors) (2016) Significant individual variation between pathologists in the evaluation of colon cancer specimens after complete mesocolic excision. Diseases of the Colon and Rectum, 59 (10). pp. 953-961. ISSN 0012-3706
Morris, EJA, Finan, PJ, Spencer, K et al. (7 more authors) (2016) Wide Variation in the Use of Radiotherapy in the Management of Surgically Treated Rectal Cancer Across the English National Health Service. Clinical Oncology, 28 (8). pp. 522-531. ISSN 0936-6555
Kraima, AC, West, NP orcid.org/0000-0002-0346-6709, Treanor, D et al. (6 more authors) (2016) The anatomy of the perineal body in relation to abdominoperineal excision for low rectal cancer. Colorectal Disease, 18 (7). pp. 688-695. ISSN 1462-8910
Seligmann, JF, Elliott, F, Richman, SD et al. (7 more authors) (2016) Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer. JAMA oncology, 2 (5). pp. 633-642. ISSN 2374-2437
Al-Temaimi, RA, Tan, TZ, Marafie, MJ et al. (3 more authors) (2016) Identification of 42 genes linked to stage II colorectal cancer metastatic relapse. International Journal of Molecular Sciences, 17 (5). 598. ISSN 1661-6596
Pahlman, LA, Hohenberger, WM, Matzel, K et al. (3 more authors) (2016) Should the Benefit of Adjuvant Chemotherapy in Colon Cancer Be Re-Evaluated? Journal of Clinical Oncology, 34 (12). pp. 1297-1299. ISSN 0732-183X
Hill, EJ, Roberts, C, Franklin, JM et al. (18 more authors) (2016) Clinical Trial of Oral Nelfinavir Before and During Radiation Therapy for Advanced Rectal Cancer. Clinical Cancer Research, 22 (8). pp. 1922-1931. ISSN 1078-0432
Battersby, NJ, How, P, Moran, B et al. (10 more authors) (2016) Prospective Validation of a Low Rectal Cancer Magnetic Resonance Imaging Staging System and Development of a Local Recurrence Risk Stratification Model: The MERCURY II Study. Annals of Surgery, 263 (4). pp. 751-760. ISSN 0003-4932
Richman, SD orcid.org/0000-0003-3993-5041, Southward, K, Chambers, P orcid.org/0000-0002-0926-717X et al. (16 more authors) (2016) HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: Analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. Journal of Pathology, 238 (4). pp. 562-570. ISSN 0022-3417
Toh, EW and Quirke, P orcid.org/0000-0002-3597-5444 (2016) The Authors Reply. Diseases of the Colon and Rectum, 59 (2). e19-e20. ISSN 1530-0358
Ruddle, RA, Thomas, RG, Randell, R orcid.org/0000-0002-5856-4912 et al. (2 more authors) (2016) The design and evaluation of interfaces for navigating gigapixel images in digital pathology. ACM Transactions on Computer-Human Interaction, 23 (1). 5. ISSN 1073-0516
Richman, SD, Adams, R, Quirke, P et al. (10 more authors) (2016) Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial. Journal of Clinical Pathology, 69 (1). pp. 35-41. ISSN 0021-9746
Kraima, AC, West, NP, Treanor, D et al. (6 more authors) (2015) Understanding the surgical pitfalls in total mesorectal excision: Investigating the histology of the perirectal fascia and the pelvic autonomic nerves. EJSO - European Journal of Surgical Oncology, 41 (12). pp. 1621-1629. ISSN 0748-7983
Young, C and Quirke, P (2015) Secrets from the microbiome: molecular biology meets microbiology meets histopathology...meets clinical biochemistry. Annals of Clinical Biochemistry, 52 (6). pp. 687-689. ISSN 0004-5632
Glynne-Jones, R, Hava, N, Goh, V et al. (18 more authors) (2015) Bevacizumab and Combination Chemotherapy in rectal cancer Until Surgery (BACCHUS): a phase II, multicentre, open-label, randomised study of neoadjuvant chemotherapy alone in patients with high-risk cancer of the rectum. BMC Cancer, 15. 764. ISSN 1471-2407
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Conference or Workshop Item
Seligmann, JF, Domingo, E, Fisher, D et al. (17 more authors) (2022) The clinical relevance of tumor RAS/TP53 dual mutation in early and metastatic colorectal cancer (CRC). In: 2022 ASCO Annual Meeting, 03-07 Jun 2022, Chicago, Il, USA and Online.
Adams, R, Fisher, D, Graham, J et al. (13 more authors) (2021) Oral maintenance capecitabine versus active monitoring for patients with metastatic colorectal cancer (mCRC) who are stable or responding after 16 weeks of first-line treatment: Results from the randomized FOCUS4-N trial. In: 2021 ASCO Annual Meeting I, 04-08 Jun 2021, Online.
Richman, SD orcid.org/0000-0003-3993-5041, Williams, CJM orcid.org/0000-0002-1574-653X, West, NP orcid.org/0000-0002-0346-6709 et al. (18 more authors) (2020) The N6 Consortium: The Northern Pathology Network. In: 2020 Joint Winter Meeting with RSM, 21-22 Jan 2020, London, UK.
West, NP, Kodavatiganti, R, Hemmings, G et al. (6 more authors) (2015) Pre-Treatment and Post-Treatment Epidermal Growth Factor Receptor Pathway Mutations in a Prospective Phase II Trial (NWCOG EXCITE) of Cetuximab-Containing Chemoradiation in Locally Advanced Rectal Cancer. In: Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathologyand the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin.
Proceedings Paper
Bach, SP, De Wilt, JHW, Peters, F et al. (18 more authors) (2022) STAR-TREC phase II: Can we save the rectum by watchful waiting or transanal surgery following (chemo)radiotherapy versus total mesorectal excision for early rectal cancer? In: Journal of Clinical Oncology. 2022 ASCO Annual Meeting I, 02-07 Jun 2022, Chicago, IL, USA. American Society of Clinical Oncology .
Murakami, K, West, N orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041 et al. (6 more authors) (2019) Central Pathological Review of the International Phase III FOxTROT Trial: Comparison with the Local Pathological Evaluation. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S39-S39.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041 et al. (6 more authors) (2019) The Effect of Pre-Operative FOLFOX Chemotherapy in Advanced Colon Cancer on Histopathological Features: Analysis of the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S38-S38.
West, NP orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041, Magill, L et al. (5 more authors) (2019) FOxTROT: An International Randomised Controlled Trial Evaluating Neoadjuvant Chemotherapy for Colon Cancer in 1,052 Patients. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S20-S20.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Westwood, AC et al. (10 more authors) (2019) The Relationship Between DNA Mismatch Repair and Response to FOLFOX-based Pre-operative Chemotherapy in the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S17-S17.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Ide, R et al. (7 more authors) (2019) The Relationship Between Tumour Immune Profile and Response to FOLFOX-Based Pre-Operative Chemotherapy in the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley-Blackwell , S37-S37.
Westwood, AC, Hemmings, GJ, Bottomley, D et al. (7 more authors) (2018) Comparison of Mismatch Repair Protein Expression Between Biopsies and Resections in Advanced Colon Cancer from the Phase II Group of the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial. In: Journal of Pathology. Maastricht Pathology 2018. 11th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 19-22 Jun 2018, Maastricht. Wiley , S26-S26.
Westwood, AC, Bottomley, D, Hemmings, GJ et al. (11 more authors) (2018) Comparison of Mutational Status in the EGFR Pathway Across Four Different Platforms in the Fluoropyrimidine Oxaliplatin and Targeted Receptor Pre-Operative Therapy (FOxTROT) Trial. In: Journal of Pathology. Maastricht Pathology 2018. 11th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 19-22 Jun 2018, Maastricht. Wiley , S15-S15.
Richman, SD orcid.org/0000-0003-3993-5041, Adams, R, Brown, E et al. (14 more authors) (2017) FOCUS4: MAMS Trial Design in Action. Early Closure of FOCUS4-D (Pan-HER 1, 2 and 3 Inhibitor Versus Placebo) in Advanced Colorectal Cancer (aCRC) Patients, with Tumours Wildtype (WT) for KRAS, NRAS, bRAF and PIK3CA. In: Journal of Pathology. Belfast Pathology 2017: 10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 20-23 Jun 2017, Belfast, Northern Ireland, UK. Wiley , S13-S13.
Seligmann, J, Wood, H orcid.org/0000-0003-3009-5904, Richman, S orcid.org/0000-0003-3993-5041 et al. (6 more authors) (2017) 545P Epidermal growth factor receptor (EGFR) copy number (CN) as a biomarker of prognosis and panitumumab (Pan) benefit in RAS-wt advanced colorectal cancer (aCRC). In: Annals of Oncology. 42nd ESMO Congress (ESMO 2017), 08-12 Sep 2017, Madrid, Spain. Oxford University Press , p. 185.
Shutkever, OG, Taylor, M, Wood, H orcid.org/0000-0003-3009-5904 et al. (5 more authors) (2017) Characterising the Gastrointestinal Microbiome in Comorbid Inflammatory Bowel Disease and Irritable Bowel Syndrome. In: Journal of Pathology. Winter meeting of the Pathological Society, 19-20 Jan 2017. Wiley , S15-S15.
Battersby, NJ, How, P, Moran, BJ et al. (10 more authors) (2016) The MERCURY II Study: Prospective Validation of a Low Rectal Cancer Assessment System Using Magnetic Resonance Imaging, and Development of a Local Recurrence Risk Stratification Model. In: Journal of Pathology. Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 Jun - 01 Jul 2016, Nottingham, UK. Wiley , S18-S18.
West, NP orcid.org/0000-0002-0346-6709, Jayne, DG orcid.org/0000-0002-8725-3283, Pigazzi, A et al. (11 more authors) (2016) Short Term Pathology Results from the First World Wide Randomised Trial of Robotic Versus Laparoscopic Resection for Rectal Cancer (ROLARR). In: Journal of Pathology. Nottingham Pathology 2016. 9th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 28 Jun - 01 Jul 2016, Nottingham, UK. Wiley , S17-S17.
Adams, RA, Brown, E, Brown, L et al. (13 more authors) (2016) FOCUS4-D: Results from a randomised, placebo controlled trial (RCT) of AZD8931 (an inhibitor of signalling by HER1, 2, and 3) in patients (pts) with advanced or metastatic colorectal cancer (aCRC) in tumours that are wildtype (wt) for BRAF, PIK3CA, KRAS & NRAS. In: Annals of Oncology. 41st ESMO Congress (ESMO 2016), 07-11 Oct 2016, Copenhagen. Oxford University Publishing .
Taylor, M, Wood, H orcid.org/0000-0003-3009-5904, Halloran, S et al. (1 more author) (2016) Exploring the suitability and stability of guaiac faecal occult blood test cards to isolate microbial DNA for 16srRNA sequencing. In: Journal of Pathology. Nottingham Pathology 2016 Meeting, 28 Jun - 01 Jul 2016, University of Nottingham, Nottingham. Wiley , S18-S18.
Wright, AI, Magee, D, Quirke, P orcid.org/0000-0002-3597-5444 et al. (1 more author) (2016) Incorporating Local and Global Context for Better Automated Analysis of Colorectal Cancer on Digital Pathology Slides. In: Procedia Computer Science. 20th Conference on Medical Image Understanding and Analysis (MIUA 2016), 06-08 Jul 2016, Loughborough University, UK. Elsevier , pp. 125-131.
Seligmann, JF, Fisher, D, Smith, CG et al. (8 more authors) (2016) Exploring outcomes of RAS-mutant (RAS mut) advanced colorectal cancer (aCRC) treated with chemotherapy: Analysis from 2254 patients (pts) in randomised clinical trials (RCTs). In: Journal of Clinical Oncology. Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), 03-07 Jun 2016, Chicago, Il. American Society of Clinical Oncology .
Kraima, A, Smit, N, Jansma, D et al. (9 more authors) (2016) The development of a 3D anatomical atlas of the pelvis: Taking the next step in enhancing surgical anatomical education and clinical guidance. In: European Journal of Cancer. European Cancer Congress 2015, 25-29 Sep 2015, Vienna, Austria. Elsevier , S357-S357.
Kraima, AC, West, NP, Treanor, D et al. (6 more authors) (2015) The Anatomy of the Perineal Body in Relation to Abdominoperineal Excision for Low Rectal Cancer. In: Journal of Pathology. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2016, Dublin, Ireland. Wiley , S39-S39.
Palmer, TG, Wood, HM, Taylor, M et al. (3 more authors) (2015) Are Current Automated Approaches for Determining the Phylogeny of Multiple Deposits Capable of Interpreting the Complexity of Cancer Evolution? In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S27-S27.
Wood, HM, Taylor, M, Do, TT et al. (1 more author) (2015) Characterising the Oral and Bowel Microbiome as a Prelude to Understanding its Role in Cancer Development Using a Next Generation Sequencing Approach. In: Journal of Pathology. Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S26-S26.
Quirke, P orcid.org/0000-0002-3597-5444 (2015) Colorectal Cancer: Updated Royal College of Pathologists’ Guidelines. In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S8-S8.
Sutton, KM, Bottomley, D, Morton, D et al. (2 more authors) (2015) Comparison of Histologically Normal Mucosa and Blood as Controls for Targeted Next Generation Sequencing Analysis in Patients with Colon Cancer in the NCRI FOxTROT Trial. In: Journal of Pathology. Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S15-S15.
Taylor, M, Wood, H, Bottomley, D et al. (9 more authors) (2015) Comparison of Mutational Calls Obtained with Pyrosequencing and the Affymetrix OncoScan (R) FFPE Assay in Patients with Colon Cancer Recruited to the NCRI FOxTROT Trial. In: Journal of Pathology. Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S39-S39.
Hughes, J, Palmer, TJ, Young, C et al. (2 more authors) (2015) Defining the Rectum and Sigmoid Colon: Should We Abolish the Term 'Rectosigmoid' to Improve Outcomes in Colorectal Cancer? In: Journal of Pathology. 8th Joint Meeting of the British Division of the International Academy of Pathologyand the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S38-S38.
Sheehan-Dare, G, Sutton, KM, Tinkler-Hundal, E et al. (3 more authors) (2015) The Effect of Multidisciplinary Education on the Quality of Colon Cancer Resection. In: Journal of Pathology. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S38-S38.
Chilton, CH, Taylor, M, Wood, HM et al. (2 more authors) (2015) An Evaluation of Culture Techniques versus 16S Profiling for Investigation of Antibiotic-Mediated Alteration of Microbiota Populations within a Clinically Reflective In Vitro Model of the Human Gut. In: Journal of Pathology. Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S21-S21.
Taylor, M, Wood, H, Tinkler-Hundal, E et al. (9 more authors) (2015) Investigating the Challenges of Using Historical Formalin-Fixed Paraffin-Embedded (FFPE) Material from the MRC CR07 Rectal Cancer Trial Using the Affymetrix OncoScan (R) FFPE Assay and Next Generation Sequencing. In: Journal of Pathology. Dublin Pathology 2015: 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S38-S38.
Jobling, ITR, Taylor, M, Young, C et al. (2 more authors) (2015) Investigating the Faecal Microbiome in Formalin Fixed Paraffin Embedded (FFPE) Material. In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S39-S39.
Richman, SD orcid.org/0000-0003-3993-5041, Hemmings, GJ, Chambers, P et al. (8 more authors) (2015) Loss of pTEN Expression is Strongly Associated with the Presence of the BRAF V600E Mutation, and Further Complicates Combination Treatment Strategies for Patients with Advanced Colorectal Cancer. In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S14-S14.
West, NP, Kodavatiganti, R, Hundal, ET et al. (2 more authors) (2015) Residual Tumour Cell Density and the Relationship to Survival Following Pre-Operative Chemoradiation in Locally Advanced Rectal Cancer: Results of the NWCOG RICE Trial. In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S22-S22.
Kraima, AC, West, NP, Treanor, D et al. (7 more authors) (2015) The Three-Dimensional Anatomy of the Anal Sphincter Complex and its Relevance to Low Rectal and Anal Pathology. In: Journal of Pathology. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S14-S14.
Kraima, AC, West, NP, Treanor, D et al. (6 more authors) (2015) Whole-Mount Microscopic Sections Reveal that Denonvilliers' Fascia is One Entity and Adherent to the Mesorectal Fascia: Should we still Question the Anterior Plane in TME? In: Journal of Pathology. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S39-S39.
Morris, EJA, Finan, PJ, Quirke, P et al. (5 more authors) (2015) Wide variation in the use of radiotherapy in the management of surgically treated rectal cancer across the english NHS. In: Gut. 2nd Digestive Disorders Federation Conference, 22-25 Jun 2015, London, UK. BMJ Publishing Group , A148-A148.
Laurent-Puig, P, Paget-Bailly, S, Vernerey, D et al. (12 more authors) (2015) Evaluation of miR 31 3p as a biomarker of prognosis and panitumumab benefit in RAS-wt advanced colorectal cancer (aCRC): Analysis of patients (pts) from the PICCOLO trial. In: Journal of Clinical Oncology. 2015 ASCO Annual Meeting, 29 May - 02 Jun 2015, Chicago, IL. American Society of Clinical Oncology .
Seligmann, JF, Fisher, D, Elliott, F et al. (8 more authors) (2015) Exploring the poor outcomes of BRAF mutant (BRAF mut) advanced colorectal cancer (aCRC): Analysis from 2,530 patients (pts) in randomized clinical trials (RCTs). In: Journal of Clinical Oncology. 2015 ASCO Annual Meeting, 29 May - 02 Jun 2015, Chicago, IL. American Society of Clinical Oncology .
Seligmann, JF, Elliott, F, Jacobs, B et al. (10 more authors) (2015) HER3 as a biomarker of prognosis and panitumumab (Pan) benefit in RAS-wt advanced colorectal cancer (aCRC). In: Journal of Clinical Oncology. 2015 ASCO Annual Meeting, 29 May - 02 Jun 2015, Chicago, IL. American Society of Clinical Oncology .
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