Items where authors include "Richman, SD"
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Niehues, JM, Quirke, P orcid.org/0000-0002-3597-5444, West, NP orcid.org/0000-0002-0346-6709 et al. (16 more authors) (2023) Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study. Cell Reports Medicine, 4 (4). 100980. ISSN 2666-3791
Corry, SM, McCorry, AMB, Lannagan, TRM et al. (31 more authors) (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71 (12). pp. 2502-2517. ISSN 0017-5749
Brown, LC, Graham, J, Fisher, D et al. (15 more authors) (2022) Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer. Clinical Trials, 19 (2). pp. 146-157. ISSN 1740-7745
West, N orcid.org/0000-0002-0346-6709, Echle, A, Laleh, NG et al. (35 more authors) (2022) Artificial intelligence for detection of microsatellite instability in colorectal cancer – a multicentric analysis of a pre-screening tool for clinical application. ESMO Open, 7 (2). ISSN 2059-7029
Richman, SD orcid.org/0000-0003-3993-5041, Hemmings, G, Roberts, H et al. (12 more authors) (2022) FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing. Journal of Clinical Pathology. ISSN 0021-9746
Seligmann, JF, Fisher, DJ, Brown, LC et al. (19 more authors) (2021) Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring. Journal of Clinical Oncology, 39 (33). pp. 3705-3715. ISSN 0732-183X
Randon, G, Yaeger, R, Hechtman, JF et al. (23 more authors) (2021) EGFR Amplification in Metastatic Colorectal Cancer. Journal of the National Cancer Institute (JNCI), 113 (11). pp. 1561-1569. ISSN 0027-8874
Adams, RA, Fisher, DJ, Graham, J et al. (19 more authors) (2021) Capecitabine Versus Active Monitoring in Stable or Responding Metastatic Colorectal Cancer After 16 Weeks of First-Line Therapy: Results of the Randomized FOCUS4-N Trial. Journal of Clinical Oncology. JCO.21.01436-JCO.21.01436. ISSN 0732-183X
Hoorn, ST, Sommeijer, DW, Elliot, F et al. (12 more authors) (2021) Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone. British Journal of Cancer. ISSN 0007-0920
Sirinukunwattana, K, Domingo, E, Richman, SD orcid.org/0000-0003-3993-5041 et al. (21 more authors) (2021) Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning. Gut, 70. pp. 544-554. ISSN 0017-5749
Dunwell, TL, Dailey, SC, Ottestad, AL et al. (13 more authors) (2021) Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA. Scientific Reports, 11. 3138. ISSN 2045-2322
Malla, SB, Fisher, DJ, Domingo, E et al. (29 more authors) (2020) In-depth clinical and biological exploration of DNA Damage Immune Response (DDIR) as a biomarker for oxaliplatin use in colorectal cancer. Clinical Cancer Research. ISSN 1078-0432
Craig, SG, Humphries, MP, Alderdice, M et al. (21 more authors) (2020) Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia. British Journal of Cancer, 123. pp. 1280-1288. ISSN 0007-0920
Echle, A, Grabsch, HI orcid.org/0000-0001-9520-6228, Quirke, P orcid.org/0000-0002-3597-5444 et al. (20 more authors) (2020) Clinical-grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159 (4). 1406-1416.e11. ISSN 0016-5085
Pulsawatdi, AV, Craig, SG, Bingham, V et al. (10 more authors) (2020) A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment. Molecular Oncology, 14 (10). pp. 2384-2402. ISSN 1574-7891
Barrow, P, Richman, SD orcid.org/0000-0003-3993-5041, Wallace, A et al. (8 more authors) (2019) Confirmation that somatic mutations of beta-2 microglobulin correlate with a lack of recurrence in a subset of stage II mismatch repair deficient colorectal cancers from the QUASAR trial. Histopathology, 75 (2). pp. 236-246. ISSN 0309-0167
Ham-Karim, HA, Ebili, HO, Bradshaw, K et al. (5 more authors) (2019) Targeted next generation sequencing reveals a common genetic pathway for colorectal cancers with chromosomal instability and those with microsatellite and chromosome stability. Pathology - Research and Practice, 215 (7). 152445. ISSN 0344-0338
Ham-Karim, HA, Ebili, HO, Manger, K et al. (4 more authors) (2019) Targeted Next-Generation Sequencing Validates the Use of Diagnostic Biopsies as a Suitable Alternative to Resection Material for Mutation Screening in Colorectal Cancer. Molecular Diagnosis & Therapy, 23 (3). pp. 383-393. ISSN 1177-1062
Richman, SD orcid.org/0000-0003-3993-5041, Fairley, J, Hall, JA et al. (5 more authors) (2018) Results of the UK NEQAS for Molecular Genetics reference sample analysis. Journal of Clinical Pathology, 71 (11). pp. 989-994. ISSN 0021-9746
Alderdice, M, Richman, SD orcid.org/0000-0003-3993-5041, Gollins, S et al. (12 more authors) (2018) Prospective patient stratification into robust cancer‐cell intrinsic subtypes from colorectal cancer biopsies. Journal of Pathology, 245 (1). pp. 19-28. ISSN 0022-3417
Seligmann, JF, Hatch, AJ, Richman, SD orcid.org/0000-0003-3993-5041 et al. (8 more authors) (2018) Association of Tumor HER3 Messenger RNA Expression With Panitumumab Efficacy in Advanced Colorectal Cancer. JAMA Oncology, 4 (4). pp. 564-568. ISSN 2374-2437
Richman, SD orcid.org/0000-0003-3993-5041, Fairley, J, Butler, R et al. (1 more author) (2017) RAS screening in colorectal cancer: a comprehensive analysis of the results from the UK NEQAS colorectal cancer external quality assurance schemes (2009–2016). Virchows Archiv, 471 (6). pp. 721-729. ISSN 0945-6317
Bosch, LJW, Trooskens, G, Snaebjornsson, P et al. (21 more authors) (2017) Decoy receptor 1 (DCR1) promoter hypermethylation and response to irinotecan in metastatic colorectal cancer. Oncotarget, 8 (38). pp. 63140-63154. ISSN 1949-2553
Seligmann, JF, Fisher, D, Smith, CG et al. (9 more authors) (2017) Investigating the poor outcomes of BRAF - mutant advanced colorectal cancer: Analysis from 2530 patients in randomised clinical trials. Annals of Oncology, 28 (3). pp. 562-568. ISSN 0923-7534
Richman, SD orcid.org/0000-0003-3993-5041, Fairley, J, Butler, R et al. (1 more author) (2017) How close are we to standardised extended RAS gene mutation testing? The UK NEQAS evaluation. Journal of Clinical Pathology, 70 (1). pp. 58-62. ISSN 0021-9746
Schoon, J, Brock, IW, Cox, A et al. (7 more authors) (2016) The effect of single nucleotide polymorphisms on clinical outcome and survival in the FOCUS (fluorouracil, oxaliplatin and irinotecan: use and sequencing) clinical trial of metastatic colorectal cancer. Anticancer Research, 36 (12). ABSTR055. pp. 6717-6718. ISSN 0250-7005
Seligmann, JF, Elliott, F, Richman, SD et al. (7 more authors) (2016) Combined Epiregulin and Amphiregulin Expression Levels as a Predictive Biomarker for Panitumumab Therapy Benefit or Lack of Benefit in Patients With RAS Wild-Type Advanced Colorectal Cancer. JAMA oncology, 2 (5). pp. 633-642. ISSN 2374-2437
Richman, SD orcid.org/0000-0003-3993-5041, Southward, K, Chambers, P orcid.org/0000-0002-0926-717X et al. (16 more authors) (2016) HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: Analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials. Journal of Pathology, 238 (4). pp. 562-570. ISSN 0022-3417
Richman, SD, Adams, R, Quirke, P et al. (10 more authors) (2016) Pre-trial inter-laboratory analytical validation of the FOCUS4 personalised therapy trial. Journal of Clinical Pathology, 69 (1). pp. 35-41. ISSN 0021-9746
Maughan, TS, Meade, AM, Adams, RA et al. (22 more authors) (2014) A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine? British Journal of Cancer, 110 (9). 2178 - 2186. ISSN 0007-0920
Conference or Workshop Item
Adams, R, Fisher, D, Graham, J et al. (13 more authors) (2021) Oral maintenance capecitabine versus active monitoring for patients with metastatic colorectal cancer (mCRC) who are stable or responding after 16 weeks of first-line treatment: Results from the randomized FOCUS4-N trial. In: 2021 ASCO Annual Meeting I, 04-08 Jun 2021, Online.
Richman, SD orcid.org/0000-0003-3993-5041, Williams, CJM orcid.org/0000-0002-1574-653X, West, NP orcid.org/0000-0002-0346-6709 et al. (18 more authors) (2020) The N6 Consortium: The Northern Pathology Network. In: 2020 Joint Winter Meeting with RSM, 21-22 Jan 2020, London, UK.
Proceedings Paper
Murakami, K, West, N orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041 et al. (6 more authors) (2019) Central Pathological Review of the International Phase III FOxTROT Trial: Comparison with the Local Pathological Evaluation. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S39-S39.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041 et al. (6 more authors) (2019) The Effect of Pre-Operative FOLFOX Chemotherapy in Advanced Colon Cancer on Histopathological Features: Analysis of the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S38-S38.
West, NP orcid.org/0000-0002-0346-6709, Richman, SD orcid.org/0000-0003-3993-5041, Magill, L et al. (5 more authors) (2019) FOxTROT: An International Randomised Controlled Trial Evaluating Neoadjuvant Chemotherapy for Colon Cancer in 1,052 Patients. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S20-S20.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Westwood, AC et al. (10 more authors) (2019) The Relationship Between DNA Mismatch Repair and Response to FOLFOX-based Pre-operative Chemotherapy in the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley , S17-S17.
Murakami, K, West, NP orcid.org/0000-0002-0346-6709, Ide, R et al. (7 more authors) (2019) The Relationship Between Tumour Immune Profile and Response to FOLFOX-Based Pre-Operative Chemotherapy in the International Phase III FOxTROT Trial. In: Journal of Pathology. Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 02-04 Jul 2019, Leeds. Wiley-Blackwell , S37-S37.
Richman, SD orcid.org/0000-0003-3993-5041, Adams, R, Brown, E et al. (14 more authors) (2017) FOCUS4: MAMS Trial Design in Action. Early Closure of FOCUS4-D (Pan-HER 1, 2 and 3 Inhibitor Versus Placebo) in Advanced Colorectal Cancer (aCRC) Patients, with Tumours Wildtype (WT) for KRAS, NRAS, bRAF and PIK3CA. In: Journal of Pathology. Belfast Pathology 2017: 10th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 20-23 Jun 2017, Belfast, Northern Ireland, UK. Wiley , S13-S13.
Richman, SD orcid.org/0000-0003-3993-5041, Hemmings, GJ, Chambers, P et al. (8 more authors) (2015) Loss of pTEN Expression is Strongly Associated with the Presence of the BRAF V600E Mutation, and Further Complicates Combination Treatment Strategies for Patients with Advanced Colorectal Cancer. In: Journal of Pathology. Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 23-25 Jun 2015, Dublin, Ireland. Wiley , S14-S14.