Items where authors include "Ottewell, P.D."

Article

Puppo, M. orcid.org/0000-0003-1409-9577, Valluru, M.K. orcid.org/0000-0001-9156-866X, Croset, M. et al. (9 more authors) (2023) MiR-662 is associated with metastatic relapse in early-stage breast cancer and promotes metastasis by stimulating cancer cell stemness. British Journal of Cancer, 129 (5). pp. 754-771. ISSN 0007-0920

Saleh, L., Ottewell, P.D. orcid.org/0000-0002-4826-0771, Brown, J.E. orcid.org/0000-0003-4960-3032 et al. (6 more authors) (2023) The CDK4/6 inhibitor palbociclib inhibits estrogen-positive and triple negative breast cancer bone metastasis in vivo. Cancers, 15 (8). 2211. ISSN 2072-6694

Kwan, A., Howard, F. orcid.org/0000-0001-9899-3079, Winder, N. et al. (13 more authors) (2022) Macrophage delivered HSV1716 is active against triple negative breast cancer. Future Pharmacology, 2 (4). pp. 444-459. ISSN 2673-9879

Zhou, J. orcid.org/0000-0003-1108-6391, Down, J.M., George, C.N. et al. (6 more authors) (2022) Novel methods of targeting IL-1 signalling for the treatment of breast cancer bone metastasis. Cancers, 14 (19). 4816.

Canuas-Landero, V.G., George, C.N., Lefley, D.V. et al. (4 more authors) (2021) Oestradiol contributes to differential antitumour effects of adjuvant zoledronic acid observed between pre- and post-menopausal women. Frontiers in Endocrinology, 12. 749428.

Quayle, L.A., Spicer, A., Ottewell, P.D. et al. (1 more author) (2021) Transcriptomic profiling reveals novel candidate genes and signalling programs in breast cancer quiescence and dormancy. Cancers, 13 (16). 3922.

Tulotta, C., Lefley, D.V., Moore, C.K. et al. (13 more authors) (2021) IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer. npj Breast Cancer, 7 (1). 95.

Hughes, R., Chen, X. orcid.org/0000-0001-6987-5540, Cowley, N. et al. (6 more authors) (2021) Osteoblast-derived paracrine and juxtacrine signals protect disseminated breast cancer cells from stress. Cancers, 13 (6). 1366. ISSN 2072-6694

Ottewell, P.D. orcid.org/0000-0002-4826-0771 and Lawson, M.A. orcid.org/0000-0002-5446-923X (2021) Advances in murine models of breast cancer bone disease. Journal of Cancer Metastasis and Treatment, 7. 11. ISSN 2394-4722

Al-Sahaf, S., Hendawi, N.B., Ollington, B. et al. (4 more authors) (2021) Increased abundance of tumour-associated neutrophils in HPV-negative compared to HPV-positive oropharyngeal squamous cell carcinoma is mediated by IL-1R signalling. Frontiers in Oral Health, 2. 604565. ISSN 2673-4842

Ran, R., Harrison, H., Syamimi Ariffin, N. et al. (9 more authors) (2020) A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells. Oncogene, 39 (12). pp. 2624-2637. ISSN 0950-9232

Eyre, R., Alférez, D.G., Santiago-Gómez, A. et al. (15 more authors) (2019) Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nature Communications, 10 (1). 5016.

Allocca, G., Hughes, R., Wang, N. orcid.org/0000-0002-2663-7515 et al. (4 more authors) (2019) The bone metastasis niche in breast cancer– potential overlap with the haematopoietic stem cell niche in vivo. Journal of Bone Oncology, 17. 100244. ISSN 2212-1374

Bishop, R.T., Marino, S., de Ridder, D. et al. (6 more authors) (2019) Pharmacological inhibition of the IKKε/TBK-1 axis potentiates the anti-tumour and anti-metastatic effects of Docetaxel in mouse models of breast cancer. Cancer Letters, 450. pp. 76-87. ISSN 0304-3835

Tulotta, C., Lefley, D.V., Freeman, K. et al. (16 more authors) (2019) Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment. Clinical Cancer Research, 25 (9). pp. 2769-2782. ISSN 1078-0432

Al-Sahaf, S., Hunter, K.D. orcid.org/0000-0002-7873-0877, Bolt, R. et al. (2 more authors) (2019) The IL-1/IL-1R axis induces greater fibroblast-derived chemokine release in human papillomavirus-negative compared to positive oropharyngeal cancer. International Journal of Cancer, 144 (2). pp. 334-344. ISSN 0020-7136

Quayle, L.A., Ottewell, P.D. orcid.org/0000-0002-4826-0771 and Holen, I. orcid.org/0000-0002-8759-6913 (2018) Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention. Clinical & Experimental Metastasis. ISSN 0262-0898

Brown, H.K., Allocca, G., Ottewell, P.D. orcid.org/0000-0002-4826-0771 et al. (5 more authors) (2018) Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer. International Journal of Molecular Sciences, 19 (10). ISSN 1661-6596

Tulotta, C. and Ottewell, P.D. orcid.org/0000-0002-4826-0771 (2018) The role of IL-1B in breast cancer bone metastasis. Endocrine-Related Cancer, 25 (7). R421-R434. ISSN 1351-0088

Ottewell, P.D. (2016) The role of osteoblasts in bone metastasis. Journal of Bone Oncology, 5 (3). pp. 124-127. ISSN 2212-1374

Wright, L.E., Ottewell, P.D. orcid.org/0000-0002-4826-0771, Rucci, N. et al. (5 more authors) (2016) Murine models of breast cancer bone metastasis. BoneKEy Reports, 5 (804). ISSN 2047-6396

Holen, I. orcid.org/0000-0002-8759-6913, Walker, M., Nutter, F. et al. (4 more authors) (2016) Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo. Clinical & Experimental Metastasis, 33 (3). pp. 211-224. ISSN 0262-0898

Westbrook, J.A., Cairns, D.A., Peng, J. et al. (10 more authors) (2016) CAPG and gipc1: Breast cancer biomarkers for bone metastasis development and treatment. Journal of the National Cancer Institute, 108 (4). ISSN 0027-8874

Wang, N., Reeves, K.J., Brown, H.K. et al. (6 more authors) (2015) The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 34. 124. ISSN 1756-9966

Holen, I., Nutter, F., Wilkinson, J.M. et al. (3 more authors) (2015) Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions. Clinical & Experimental Metastasis, 32 (7). 689 - 702. ISSN 0262-0898

Ottewell, P.D., Wang, N., Brown, H.K. et al. (4 more authors) (2015) OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone. International Journal of Cancer, 137 (4). 968 - 977. ISSN 0020-7136

Wang, N., Docherty, F., Brown, H.K. et al. (7 more authors) (2015) Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer. FASEB Journal, 29 (8). pp. 3141-3150. ISSN 0892-6638

Ottewell, P.D., O'Donnell, L. and Holen, I. orcid.org/0000-0002-8759-6913 (2015) Molecular alterations that drive breast cancer metastasis to bone. Bonekey Reports, 4. p. 643. ISSN 2047-6396

Wang, N., Docherty, F.E., Brown, H.K. et al. (7 more authors) (2014) Prostate Cancer Cells Preferentially Home to Osteoblast-rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models. Journal of Bone and Mineral Research , 29 (12). pp. 2688-2696. ISSN 0884-0431

Ottewell, P.D., Wang, N. orcid.org/0000-0002-2663-7515, Brown, H.K. et al. (5 more authors) (2014) Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment In Vivo. Clinical Cancer Research, 20 (11). pp. 2922-2932. ISSN 1078-0432

Brown, H.K., Ottewell, P.D., Evans, C.A. et al. (2 more authors) (2012) A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts. Journal of Bone Oncology, 1. pp. 47-56. ISSN 2212-1374

Holen, I., Whitworth, J., Nutter, F. et al. (6 more authors) (2012) Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo. Breast Cancer Research, 14. R86 . ISSN 1465-5411

Brown, H.K., Ottewell, P.D., Coleman, R.E. et al. (1 more author) (2011) The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells. Journal of Cellular and Molecular Medicine, 15 (3). 501 - 513. ISSN 1582-1838

Book Section

Ottewell, P.D. orcid.org/0000-0002-4826-0771 and Quayle, L.A. (2019) Tumor dormancy in the bone. In: Reference Module in Biomedical Sciences. Elsevier . ISBN 978-0-12-801238-3

Conference or Workshop Item

Ottewell, P.D., Lefley, D.V., Coleman, R.E. et al. (1 more author) (2008) Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid. In: Breast Cancer Research 2008, 13 May 2008, London, UK.

Lefley, D.V., Holen, I., Coleman, R.E. et al. (1 more author) (2008) Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid. In: Breast Cancer Research 2008, May 2008, London, UK.

Ottewell, P.D., Jones, M., Coleman, R.E. et al. (1 more author) (2006) Synergistic effects of cytotoxic drugs and antiresorptive agents in vitro and in vivo. In: Breast cancer research: the past and the future, 1 November 2006, London, UK.