Items where authors include "Mortiboys, H."

Article

Bell, S.M. orcid.org/0000-0002-2781-6478, Wareing, H. orcid.org/0000-0003-0785-4116, Capriglia, F. orcid.org/0000-0001-7113-1276 et al. (14 more authors) (2025) Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer’s disease astrocytes. Molecular Psychiatry, 30 (4). pp. 1369-1382. ISSN 1359-4184

Au, W.H. orcid.org/0009-0006-1068-9560, Miller-Fleming, L. orcid.org/0000-0002-3593-6461, Sanchez-Martinez, A. orcid.org/0000-0002-2728-6251 et al. (9 more authors) (2024) Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Life Science Alliance, 7 (9). e202402853. ISSN 2575-1077

Xia, Z., Prescott, E.E., Urbanek, A. et al. (28 more authors) (2024) Co-aggregation with apolipoprotein E modulates the function of amyloid-β in Alzheimer's disease. Nature Communications, 15. 4695. ISSN 2041-1723

McCarron, K.R., Elcocks, H., Mortiboys, H. orcid.org/0000-0001-6439-0579 et al. (2 more authors) (2024) The Parkinson's disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress. Biochemical Journal, 481 (4). pp. 265-278. ISSN 0264-6021

Harvey, C., Weinreich, M. orcid.org/0009-0003-1576-3385, Lee, J.A.K. orcid.org/0000-0001-9843-6475 et al. (22 more authors) (2024) Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis. Heliyon, 10 (3). e24975. ISSN 2405-8440

Payne, T. orcid.org/0000-0001-6753-7847, Burgess, T., Bradley, S. et al. (12 more authors) (2023) Multimodal assessment of mitochondrial function in Parkinson's disease. Brain, 147 (1). pp. 267-280. ISSN 0006-8950

Mihaylov, S.R. orcid.org/0000-0001-6872-0635, Castelli, L.M., Lin, Y.-H. orcid.org/0000-0003-1576-4655 et al. (13 more authors) (2023) The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nature Communications, 14. 5496.

Bellantuono, I., Mortiboys, H. orcid.org/0000-0001-6439-0579, Rocha, E. et al. (17 more authors) (2023) Aging, Parkinson’s disease, and models: what are the challenges? Aging Biology, 1. pp. 1-30. ISSN 1474-9718

Capriglia, F. orcid.org/0000-0001-7113-1276, Burgess, T., Bandmann, O. orcid.org/0000-0003-3149-0252 et al. (1 more author) (2023) Clinical trial highlights: modulators of mitochondrial function. Journal of Parkinson’s Disease, 13 (6). pp. 851-864. ISSN 1877-7171

Elcocks, H. orcid.org/0000-0002-1248-0684, Brazel, A.J. orcid.org/0000-0001-5070-2236, McCarron, K.R. orcid.org/0000-0002-9281-4030 et al. (5 more authors) (2023) FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels. The EMBO Journal, 42 (13). e112799. ISSN 0261-4189

Foltynie, T. orcid.org/0000-0003-0752-1813, Gandhi, S., Gonzalez-Robles, C. et al. (85 more authors) (2023) Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson’s disease. Brain, 146 (7). pp. 2717-2722. ISSN 0006-8950

Keatinge, M. orcid.org/0000-0003-2055-1187, Gegg, M.E., Watson, L. et al. (10 more authors) (2023) Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency. Disease Models & Mechanisms, 16 (6). ISSN 1754-8403

Morsli, S. orcid.org/0000-0002-0371-0732, Henriques, C.M. orcid.org/0000-0003-1882-756X, Ellis, P.S. et al. (5 more authors) (2023) A p21‐GFP zebrafish model of senescence for rapid testing of senolytics in vivo. Aging Cell, 22 (6). e13835. ISSN 1474-9718

Luxenburger, A. orcid.org/0000-0002-7574-8027, Clemmens, H., Hastings, C. et al. (8 more authors) (2023) 3α,7-dihydroxy-14(13→12)abeo-5β,12α(H),13β(H)-cholan-24-oic acids display neuroprotective properties in common forms of Parkinson’s disease. Biomolecules, 13 (1). 76. ISSN 2218-273X

Rusilowicz-Jones, E.V., Barone, F.G., Martins Lopes, F. et al. (4 more authors) (2022) Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. Life Science Alliance, 5 (2). e202101287.

Vazquez‐Villasenor, I., Garwood, C.J., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (3 more authors) (2021) Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience, 54 (9). pp. 6987-7005. ISSN 0953-816X

Frison, M., Faccenda, D., Abeti, R. et al. (14 more authors) (2021) The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Molecular Psychiatry, 26 (7). pp. 2721-2739. ISSN 1359-4184

Gatto, N., Dos Santos Souza, C., Shaw, A.C. et al. (12 more authors) (2021) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell, 20 (1). e13281. ISSN 1474-9718

Bell, S.M., Barnes, K., De Marco, M. orcid.org/0000-0002-9240-8067 et al. (5 more authors) (2021) Mitochondrial dysfunction in Alzheimer’s disease : a biomarker of the future? Biomedicines, 9 (1). 63.

Leah, T., Vazquez-Villaseñor, I., Ferraiuolo, L. et al. (2 more authors) (2021) A Parkinson’s disease-relevant mitochondrial and neuronal morphology high-throughput screening assay in LUHMES cells. Bio-protocol, 11 (1). ISSN 2331-8325

Bell, S.M., De Marco, M. orcid.org/0000-0002-9240-8067, Barnes, K. et al. (5 more authors) (2020) Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer’s disease? Alzheimer's & Dementia, 16 (S6). e037527. ISSN 1552-5260

Sassani, M., Alix, J., McDermott, C. et al. (6 more authors) (2020) Magnetic resonance spectroscopy reveals mitochondrial dysfunction in amyotrophic lateral sclerosis. Brain, 143 (12). pp. 3603-3618. ISSN 0006-8950

Bell, S.M., Burgess, T., Lee, J. et al. (3 more authors) (2020) Peripheral glycolysis in neurodegenerative diseases. International Journal of Molecular Sciences, 21 (23). 8924. ISSN 1661-6596

Schwartzentruber, A., Boschian, C., Lopes, F.M. et al. (6 more authors) (2020) Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons. Scientific Reports, 10 (1). 15485. ISSN 2045-2322

Rusilowicz-Jones, E.V., Jardine, J., Kallinos, A. et al. (26 more authors) (2020) USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation. Life Science Alliance, 3 (8). e202000768. ISSN 2575-1077

Bell, S.M., De Marco, M., Barnes, K. et al. (5 more authors) (2020) Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of alzheimer’s disease. Journal of Personalized Medicine, 10 (2). 32. ISSN 2075-4426

Carling, P.J., Mortiboys, H. orcid.org/0000-0001-6439-0579, Green, C. et al. (21 more authors) (2020) Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease. Progress in Neurobiology, 187. 101772. ISSN 0301-0082

Allen, S.P., Hall, B., Woof, R. et al. (16 more authors) (2019) C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis. Brain. 302. pp. 1-20. ISSN 0006-8950

López, K.L.R., Simpson, J.E. orcid.org/0000-0002-3753-4271, Watson, L.C. et al. (4 more authors) (2019) TIGAR inclusion pathology is specific for Lewy body diseases. Brain Research, 1706. pp. 218-223. ISSN 0006-8993

Bell, S.M., Barnes, K., Clemmens, H. et al. (8 more authors) (2018) Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with either Sporadic or Familial Alzheimer's Disease. Journal of Molecular Biology, 430 (21). ISSN 0022-2836

Ratcliffe, L.E., Vázquez Villaseñor, I., Jennings, L. et al. (8 more authors) (2018) Loss of IGF1R in human astrocytes alters complex I activity and support for neurons. Neuroscience, 390. pp. 46-59. ISSN 0306-4522

Macdonald, R. orcid.org/0000-0002-1344-3826, Barnes, K., Hastings, C. et al. (1 more author) (2018) Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically? Biochemical Society Transactions , 46 (4). pp. 891-909. ISSN 0300-5127

Mortiboys, H., MacDonald, R., Payne, T. et al. (3 more authors) (2018) Translational approaches to restoring mitochondrial function in Parkinson's disease. FEBS Letters, 592 (5). pp. 776-792. ISSN 0014-5793

Dombi, E., Mortiboys, H. and Poulton, J. (2018) Modulating mitophagy in mitochondrial disease. Current Medicinal Chemistry, 25 (40). pp. 5597-5612. ISSN 0929-8673

Soman, S., Keatinge, M., Moein, M. et al. (7 more authors) (2017) Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish. European Journal of Neuroscience, 45 (4). pp. 528-535. ISSN 0953-816X

Liao, C., Ashley, N., Diot, A. et al. (30 more authors) (2017) Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations. Neurology, 88 (2). pp. 131-142. ISSN 0028-3878

Mortiboys, H. (2016) Screening for chemical modulators for LRRK2. Biochemical Society Transactions, 44 (6). pp. 1617-1623. ISSN 0300-5127

Yealland, G., Battaglia, G., Bandmann, O. orcid.org/0000-0003-3149-0252 et al. (1 more author) (2016) Rescue of mitochondrial function in parkin-mutant Fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes. Neuroscience Letters. ISSN 0304-3940

Keatinge, M., Bui, H., Menke, A. et al. (23 more authors) (2015) Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death. Human Molecular Genetics, 24 (23). pp. 6640-6652. ISSN 0964-6906

Pogson, J.H., Ivatt, R.M., Sanchez-Martinez, A. et al. (4 more authors) (2014) The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy. PLoS Genetics, 10 (11). e1004815. ISSN 1553-7390

Cox, L.E., Ferraiuolo, L., Goodall, E.F. et al. (13 more authors) (2010) Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). Plos One, 5 (3). Art no.e9872. ISSN 1932-6203

Tain, L.S., Mortiboys, H., Tao, R.N. et al. (3 more authors) (2009) Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nature Neuroscience , 12 (9). pp. 1129-1135. ISSN 1097-6256

Proceedings Paper

Sassani, M., Alix, J. orcid.org/0000-0001-8391-9749, Mcdermott, C. et al. (7 more authors) (2021) Brain energy metabolism in ALS : a phosphorus-31 magnetic resonance spectroscopy study. In: Journal of the Neurological Sciences. World Congress of Neurology (WCN 2021), 03-07 Oct 2021, Rome, Italy. Elsevier BV , p. 119412.

Bell, S., De Marco, M., Barnes, K. et al. (5 more authors) (2020) Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer's disease? In: Neurology. UNSPECIFIED. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology .