Items where authors include "Knowles, MA"

Article

Pettitt, GA, Hurst, CD, Khan, Z et al. (7 more authors) (2023) Development of resistance to FGFR inhibition in urothelial carcinoma via multiple pathways in vitro. Journal of Pathology, 259 (2). pp. 220-232. ISSN 0022-3417

Warrick, JI, Knowles, MA orcid.org/0000-0002-9363-8657, Hurst, CD et al. (9 more authors) (2022) A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma. Scientific Reports, 12 (1). 16538. ISSN 2045-2322

Marzouka, N-A-D, Eriksson, P, Bernardo, C et al. (5 more authors) (2022) The Lund Molecular Taxonomy Applied to Non–Muscle-Invasive Urothelial Carcinoma. The Journal of Molecular Diagnostics, 24 (9). pp. 992-1008. ISSN 1525-1578

Hurst, CD orcid.org/0000-0001-7719-1325 and Knowles, MA orcid.org/0000-0002-9363-8657 (2022) Mutational landscape of non-muscle-invasive bladder cancer. Urologic Oncology, 40 (7). pp. 295-303. ISSN 1078-1439

Kpeglo, D, Hughes, MDG, Dougan, L orcid.org/0000-0002-2620-5827 et al. (4 more authors) (2022) Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma. Matrix Biology Plus, 14. 100109. ISSN 2590-0285

Hurst, CD, Cheng, G, Platt, FM et al. (7 more authors) (2022) Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling. The Journal of Pathology: Clinical Research, 8 (3). pp. 279-293. ISSN 2056-4538

Turner, LD, Trinh, CH orcid.org/0000-0002-5087-5011, Hubball, RA et al. (5 more authors) (2022) From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. Journal of Medicinal Chemistry, 65 (2). pp. 1481-1504. ISSN 0022-2623

Hurst, CD, Cheng, G, Platt, FM et al. (16 more authors) (2021) Stage-stratified molecular profiling of non-muscle-invasive bladder cancer provides improved biological, clinical and therapeutic insights. Cell Reports Medicine, 2 (12). 100472. ISSN 2666-3791

Lindskrog, SV, Prip, F, Lamy, P et al. (44 more authors) (2021) An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer. Nature Communications, 12 (1). 2301. ISSN 2041-1723

Burns, JE, Hurst, CD, Knowles, MA orcid.org/0000-0002-9363-8657 et al. (2 more authors) (2021) The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. Cancer Science. cas.15047. ISSN 1347-9032

Thangsunan, P, Lal, N, Tiede, C et al. (8 more authors) (2021) Affimer-based impedimetric biosensors for fibroblast growth factor receptor 3 (FGFR3): a novel tool for detection and surveillance of recurrent bladder cancer. Sensors and Actuators B: Chemical, 326. 128829. ISSN 0925-4005

Knowles, MA orcid.org/0000-0002-9363-8657 (2020) FGFR3 – a Central Player in Bladder Cancer Pathogenesis? Bladder Cancer, 6 (4). pp. 403-423. ISSN 2352-3727

Clausen, TM, Kumar, G, Ibsen, EK et al. (12 more authors) (2020) A simple method for detecting oncofetal chondroitin sulfate glycosaminoglycans in bladder cancer urine. Cell Death Discovery, 6 (1). 65. ISSN 2058-7716

Pritchard, JJG, Hamilton, G, Hurst, CD et al. (6 more authors) (2020) Monitoring of urothelial cancer disease status after treatment by digital droplet PCR liquid biopsy assays. Urologic Oncology: Seminars and Original Investigations, 38 (9). 737.e1-737.e10. ISSN 1078-1439

Warrick, JI, Knowles, MA orcid.org/0000-0002-9363-8657, Yves, A et al. (6 more authors) (2020) Report From the International Society of Urological Pathology (ISUP) Consultation Conference On Molecular Pathology Of Urogenital Cancers. II. Molecular Pathology of Bladder Cancer: Progress and Challenges. The American Journal of Surgical Pathology, 44 (7). e30-e46. ISSN 0147-5185

Mostafid, AH, Porta, N, Cresswell, J et al. (14 more authors) (2020) CALIBER: a phase II randomized feasibility trial of chemoablation with mitomycin‐C vs surgical management in low‐risk non‐muscle‐invasive bladder cancer. BJU International, 125 (6). pp. 817-826. ISSN 1464-4096

Di Martino, E, Alder, O orcid.org/0000-0002-7975-9727, Hurst, CD orcid.org/0000-0001-7719-1325 et al. (1 more author) (2019) ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer. Scientific Reports, 9. ARTN: 5740. ISSN 2045-2322

Foth, M, Ismail, NFB, Kung, JSC et al. (7 more authors) (2018) FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation. Journal of Pathology, 246 (3). pp. 331-343. ISSN 0022-3417

Mellor, P, Marshall, JDS, Ruan, X et al. (5 more authors) (2018) Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. Scientific Reports, 8. 7108. ISSN 2045-2322

Hurst, CD and Knowles, MA orcid.org/0000-0002-9363-8657 (2018) Bladder cancer: Multi-omic profiling refines the molecular view. Nature Reviews Clinical Oncology, 15. pp. 203-204. ISSN 1759-4774

Turner, LD, Summers, AJ, Johnson, LO et al. (2 more authors) (2017) Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ACS Medicinal Chemistry Letters, 8 (12). pp. 1264-1268. ISSN 1948-5875

Hurst, CD orcid.org/0000-0001-7719-1325, Alder, O orcid.org/0000-0002-7975-9727, Platt, FM et al. (15 more authors) (2017) Genomic Subtypes of Non-Invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency. Cancer Cell, 32 (5). pp. 701-715. ISSN 1535-6108

Lombardi, B, Ashford, P, Moya-Garcia, AA et al. (7 more authors) (2017) Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis. Oncotarget, 8 (61). pp. 102898-102911. ISSN 1949-2553

Berrout, J, Kyriakopoula, E, Moparthi, L et al. (27 more authors) (2017) TRPA1- FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p. Nature Communications, 8. 947. ISSN 2041-1723

Sanli, O, Dobruch,, J, Knowles, MA orcid.org/0000-0002-9363-8657 et al. (4 more authors) (2017) Bladder Cancer. Nature Reviews Disease Primers, 3. 17022. ISSN 2056-676X

Di Martino, E, Tomlinson, DC orcid.org/0000-0003-4134-7484, Williams, SV et al. (1 more author) (2016) A place for precision medicine in bladder cancer: targeting the FGFRs. Future Oncology, 12 (19). pp. 2243-2263. ISSN 1479-6694

Baldia, PH, Maurer, A, Heide, T et al. (7 more authors) (2016) Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup. Oncotarget.

Ross, RL, McPherson, HR, Kettlewell, L et al. (4 more authors) (2016) PIK3CA dependence and sensitivity to therapeutic targeting in urothelial carcinoma. BMC Cancer, 16. 553. ISSN 1471-2407

Pouessel, D, Neuzillet, Y, Mertens, LS et al. (35 more authors) (2016) Tumor Heterogeneity of Fibroblast Growth Factor Receptor 3 (FGFR3) Mutations in Invasive Bladder Cancer: Implications for Peri-Operative anti-FGFR3 Treatment. Annals of Oncology, 27 (7). pp. 1311-1316. ISSN 0923-7534

Patani, H, Bunney, TD, Thiyagarajan, N et al. (14 more authors) (2016) Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use. Oncotarget, 7 (17). pp. 24252-24268. ISSN 1949-2553

De Faveri, LE, Hurst, CD, Roulson, J et al. (4 more authors) (2015) Polycomb repressor complex 1 member, BMI1 contributes to urothelial tumorigenesis through p16-independent mechanisms. Translational Oncology, 8 (5). pp. 387-399. ISSN 1944-7124

Ambrose, SR, Gordon, NS, Goldsmith, JC et al. (6 more authors) (2015) Use of Aleuria alantia Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer. Proteomes, 3 (3). 266 - 282. ISSN 2227-7382

Burghel, GJ, Hurst, CD, Watson, CM et al. (4 more authors) (2015) Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms. BioMed Research International, 2015. 478017. ISSN 2314-6133

Stoehr, R, Taubert, H, Zinnall, U et al. (8 more authors) (2015) Frequency of TERT promoter mutations in prostate cancer. Pathobiology, 82 (2). pp. 53-57. ISSN 1015-2008

Bryan, RT, Regan, HL, Pirrie, SJ et al. (6 more authors) (2015) Protein shedding in urothelial bladder cancer: Prognostic implications of soluble urinary EGFR and EpCAM. British Journal of Cancer, 112 (6). 1052 - 1058. ISSN 0007-0920

Bunney, TD, Wan, S, Thiyagarajan, N et al. (8 more authors) (2015) The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study. EBiomedicine, 2 (3). 194 - 204.

Di Martino, E, Kelly, G, Roulson, JA et al. (1 more author) (2015) Alteration of cell-cell and cell-matrix adhesion in urothelial cells: An oncogenic mechanism for mutant FGFR3. Molecular Cancer Research, 13 (1). 138 - 148. ISSN 1541-7786

Turo, R, Harnden, P, Thygesen, H et al. (5 more authors) (2015) FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases. Journal of Urology, 193 (1). 325 - 330. ISSN 0022-5347

Knowles, MA and Hurst, CD (2014) Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity. Nature Reviews Cancer, 15 (1). 25 - 41. ISSN 1474-175X

Goebell, PJ, Kamat, AM, Sylvester, RJ et al. (10 more authors) (2014) Assessing the quality of studies on the diagnostic accuracy of tumor markers. Urologic Oncology: Seminars and Original Investigations, 32 (7). 1051 - 1060. ISSN 1078-1439

Acquaviva, J, He, S, Zhang, C et al. (11 more authors) (2014) FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. Molecular Cancer Research, 12 (7). 1042 - 1054. ISSN 1541-7786

Rafnar, T, Sulem, P, Thorleifsson, G et al. (72 more authors) (2014) Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. Human Molecular Genetics, 23 (20). 5545 - 5557. ISSN 0964-6906

Taylor, CF, Platt, FM, Hurst, CD orcid.org/0000-0001-7719-1325 et al. (2 more authors) (2014) Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes. Human Molecular Genetics, 23 (8). pp. 1964-1974. ISSN 0964-6906

Teo, MT, Dyrskjøt, L, Nsengimana, J et al. (11 more authors) (2014) Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer. Annals of Oncology, 25 (4). 877 - 883. ISSN 0923-7534

Hurst, CD and Knowles, MA (2014) Molecular subtyping of invasive bladder cancer: time to divide and rule? Cancer Cell, 25 (2). 135 - 136. ISSN 1535-6108

Stadler, LK, Tomlinson, DC, Lee, T et al. (2 more authors) (2014) The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function. Cell Death and Disease, 5. e1037. e1037 - e1037. ISSN 2041-4889

Herrera-Abreu, MT, Pearson, A, Campbell, J et al. (4 more authors) (2013) Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer. Cancer Discovery, 3 (9). 1058 - 1071. ISSN 2159-8274

Di Martino, E, Taylor, CF, Roulson, J-A et al. (1 more author) (2013) An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer. Genes Chromosomes and Cancer, 52 (9). pp. 860-871. ISSN 1045-2257

Blick, C, Ramachandran, A, Wigfield, S et al. (8 more authors) (2013) Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer. British Journal of Cancer, 109 (1). pp. 50-59. ISSN 0007-0920

De Faveri, LE, Hurst, CD orcid.org/0000-0001-7719-1325, Platt, FM et al. (5 more authors) (2013) Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer. British Journal of Cancer, 108 (6). pp. 1368-1377. ISSN 0007-0920

Qiao, BL, Ansari, AH, Scott, GB orcid.org/0000-0003-0021-9400 et al. (11 more authors) (2011) In vitro functional effects of XPC gene rare variants from bladder cancer patients. Carcinogenesis, 32 (4). pp. 516-521. ISSN 0143-3334

Rothman, N, Garcia-Closas, M, Chatterjee, N et al. (107 more authors) (2010) A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nature Genetics, 42 (11). 978-U98. ISSN 1061-4036