Items where authors include "Holen, I."

Article

Llorente, A. orcid.org/0000-0002-6056-0566, Blasco, M.T. orcid.org/0000-0001-9531-2522, Espuny, I. orcid.org/0000-0003-1906-4947 et al. (20 more authors) (2023) MAF amplification licenses ERα through epigenetic remodelling to drive breast cancer metastasis. Nature Cell Biology, 25 (12). pp. 1833-1847. ISSN 1465-7392

Saleh, L., Ottewell, P.D. orcid.org/0000-0002-4826-0771, Brown, J.E. orcid.org/0000-0003-4960-3032 et al. (6 more authors) (2023) The CDK4/6 inhibitor palbociclib inhibits estrogen-positive and triple negative breast cancer bone metastasis in vivo. Cancers, 15 (8). 2211. ISSN 2072-6694

Thorne, J.L. orcid.org/0000-0002-3037-8528, Holen, I. orcid.org/0000-0002-8759-6913 and Corfe, B.M. (2023) The second Nutrition and Cancer Networking meeting Nutrition and breast cancer: translating evidence into practice. Proceedings of the Nutrition Society, 82 (1). pp. 58-62. ISSN 0029-6651

Chen, X. orcid.org/0000-0001-6987-5540, Hughes, R., Mullin, N. et al. (4 more authors) (2021) Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases. Nanoscale, 13 (43). pp. 18237-18246. ISSN 2040-3364

Quayle, L.A., Spicer, A., Ottewell, P.D. et al. (1 more author) (2021) Transcriptomic profiling reveals novel candidate genes and signalling programs in breast cancer quiescence and dormancy. Cancers, 13 (16). 3922.

Clezardin, P. orcid.org/0000-0003-0149-4463, Coleman, R., Puppo, M. et al. (5 more authors) (2021) Bone metastasis : mechanisms, therapies and biomarkers. Physiological Reviews, 101 (3). pp. 797-855. ISSN 0031-9333

Chen, X. orcid.org/0000-0001-6987-5540, Hughes, R., Mullin, N. et al. (4 more authors) (2021) Atomic force microscopy reveals the mechanical properties of breast cancer bone metastases. bioRxiv. (Submitted)

Hughes, R., Chen, X. orcid.org/0000-0001-6987-5540, Cowley, N. et al. (6 more authors) (2021) Osteoblast-derived paracrine and juxtacrine signals protect disseminated breast cancer cells from stress. Cancers, 13 (6). 1366. ISSN 2072-6694

Chen, X. orcid.org/0000-0001-6987-5540, Hughes, R., Mullin, N. et al. (4 more authors) (2020) Mechanical heterogeneity in the bone microenvironment as characterized by atomic force microscopy. Biophysical Journal, 119 (3). pp. 502-513. ISSN 0006-3495

Ran, R., Harrison, H., Syamimi Ariffin, N. et al. (9 more authors) (2020) A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells. Oncogene, 39 (12). pp. 2624-2637. ISSN 0950-9232

Chen, X. orcid.org/0000-0001-6987-5540, Hughes, R., Mullin, N. et al. (4 more authors) (2020) Mechanical heterogeneity in the bone microenvironment as characterised by atomic force microscopy. bioRxiv. (Submitted)

Saleh, L., Wilson, C. and Holen, I. orcid.org/0000-0002-8759-6913 (2020) CDK4/6 inhibitors in breast cancer – from in vitro models to clinical trials. Acta Oncologica, 59 (2). pp. 219-232. ISSN 0284-186X

Lefley, D., Howard, F., Arshad, F. et al. (9 more authors) (2019) Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts. Breast Cancer Research, 21 (1). 130. ISSN 1465-5411

Hughes, R., Chen, X. orcid.org/0000-0001-6987-5540, Hunter, K.D. orcid.org/0000-0002-7873-0877 et al. (3 more authors) (2019) Bone marrow osteoprogenitors are depleted whereas osteoblasts are expanded independent of the osteogenic vasculature in response to zoledronic acid. The FASEB Journal, 33 (11). pp. 12768-12779. ISSN 0892-6638

Allocca, G., Hughes, R., Wang, N. orcid.org/0000-0002-2663-7515 et al. (4 more authors) (2019) The bone metastasis niche in breast cancer– potential overlap with the haematopoietic stem cell niche in vivo. Journal of Bone Oncology, 17. 100244. ISSN 2212-1374

Tulotta, C., Lefley, D.V., Freeman, K. et al. (16 more authors) (2019) Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment. Clinical Cancer Research, 25 (9). pp. 2769-2782. ISSN 1078-0432

Quayle, L.A., Ottewell, P.D. orcid.org/0000-0002-4826-0771 and Holen, I. orcid.org/0000-0002-8759-6913 (2018) Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention. Clinical & Experimental Metastasis, 35 (8). pp. 831-846. ISSN 0262-0898

Brown, H.K., Allocca, G., Ottewell, P.D. orcid.org/0000-0002-4826-0771 et al. (5 more authors) (2018) Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer. International Journal of Molecular Sciences, 19 (10). 2920. ISSN 1661-6596

Ubellacker, J.M., Baryawno, N., Severe, N. et al. (13 more authors) (2018) Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer. Cancer Research , 78 (18). ISSN 0008-5472

Mittal, S., Brown, N.J. orcid.org/0000-0002-2100-1905 and Holen, I. orcid.org/0000-0002-8759-6913 (2018) The breast tumor microenvironment: role in cancer development, progression and response to therapy. Expert Review of Molecular Diagnostics, 18 (3). pp. 227-243. ISSN 1473-7159

Holen, I. orcid.org/0000-0002-8759-6913, Speirs, V., Morrissey, B. et al. (1 more author) (2017) In vivo models in breast cancer research: progress, challenges and future directions. Disease Models and Mechanisms, 10. pp. 359-371. ISSN 1754-8403

Ubellacker, J.M., Haider, M.T., DeCristo, M.J. et al. (5 more authors) (2017) Zoledronic acid alters hematopoiesis and generates breast tumor-suppressive bone marrow cells. Breast Cancer Research, 19 (1). 23. ISSN 1465-5411

Morrissey, B., Blyth, K., Carter, P. et al. (4 more authors) (2017) The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research. PLoS Biology, 15 (1). e2000719. ISSN 1544-9173

Wilson, C., Brown, H. and Holen, I. orcid.org/0000-0002-8759-6913 (2016) The endocrine influence on the bone microenvironment in early breast cancer. Endocrine-Related Cancer, 23. R567-R576. ISSN 1351-0088

Morrissey, B., Holen, I. orcid.org/0000-0002-8759-6913, Chelala, C. et al. (4 more authors) (2016) Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research. npj Breast Cancer, 2 (1). 16020.

Holen, I. orcid.org/0000-0002-8759-6913 (2016) The bone microenvironment - multiple players involved in cancer progression. Journal of Bone Oncology, 5 (3). pp. 87-89. ISSN 2212-1366

Carter, P., Blyth, K., Holen, I. orcid.org/0000-0002-8759-6913 et al. (4 more authors) (2016) The SEARCHBreast portal: A virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies. Open Journal of Bioresources, 3. e4. ISSN 2056-5542

Speirs, V., Morrisey, B., Holen, I. orcid.org/0000-0002-8759-6913 et al. (4 more authors) (2016) SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals. Breast Cancer Research and Treatment, 156 (3). pp. 447-452. ISSN 0167-6806

Morrissey, B., Blyth, K., Carter, P. et al. (4 more authors) (2016) SEARCHBreast: A new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers. Breast Cancer Research, 18 (1). ISSN 1465-5411

De Felice, M., Lambert, D., Holen, I. et al. (2 more authors) (2016) Effects of Src-kinase inhibition in cancer-induced bone pain. Molecular Pain, 12. ISSN 1744-8069

Blyth, K., Carter, P., Morrissey, B. et al. (4 more authors) (2016) SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Breast Cancer Research and Treatment, 156 (3). pp. 447-452. ISSN 0167-6806

Holen, I. orcid.org/0000-0002-8759-6913, Walker, M., Nutter, F. et al. (4 more authors) (2016) Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo. Clinical & Experimental Metastasis, 33 (3). pp. 211-224. ISSN 0262-0898

Westbrook, J.A., Cairns, D.A., Peng, J. et al. (10 more authors) (2016) CAPG and gipc1: Breast cancer biomarkers for bone metastasis development and treatment. Journal of the National Cancer Institute, 108 (4). ISSN 0027-8874

Holen, I. orcid.org/0000-0002-8759-6913, Lefley, D.V., Francis, S.E. et al. (4 more authors) (2016) IL-1 drives breast cancer growth and bone metastasis in vivo. Oncotarget, 7. pp. 75571-75584. ISSN 1949-2553

Haider, M.-T., Hunter, K.D. orcid.org/0000-0002-7873-0877, Robinson, S.P. et al. (6 more authors) (2015) Rapid modification of the bone microenvironment following short-term treatment with Cabozantinib in vivo. BONE, 81. pp. 581-592. ISSN 8756-3282

Wang, N., Reeves, K.J., Brown, H.K. et al. (6 more authors) (2015) The frequency of osteolytic bone metastasis is determined by conditions of the soil, not the number of seeds; evidence from in vivo models of breast and prostate cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 34. 124. ISSN 1756-9966

Holen, I., Nutter, F., Wilkinson, J.M. et al. (3 more authors) (2015) Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions. Clinical & Experimental Metastasis, 32 (7). 689 - 702. ISSN 0262-0898

Ottewell, P.D., Wang, N., Brown, H.K. et al. (4 more authors) (2015) OPG-Fc inhibits ovariectomy-induced growth of disseminated breast cancer cells in bone. International Journal of Cancer, 137 (4). 968 - 977. ISSN 0020-7136

Wang, N., Docherty, F., Brown, H.K. et al. (7 more authors) (2015) Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer. FASEB Journal, 29 (8). pp. 3141-3150. ISSN 0892-6638

Ottewell, P.D., O'Donnell, L. and Holen, I. orcid.org/0000-0002-8759-6913 (2015) Molecular alterations that drive breast cancer metastasis to bone. Bonekey Reports, 4. p. 643. ISSN 2047-6396

Talari, A.C.S., Evans, C.A., Holen, I. et al. (2 more authors) (2015) Raman spectroscopic analysis differentiates between breast cancer cell lines. Journal of Raman Spectroscopy, 46 (5). 421 - 427. ISSN 0377-0486

Wilson, C., Ottewell, P., Coleman, R.E. et al. (1 more author) (2015) The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway. BMC Cancer, 15. 55. ISSN 1471-2407

Wang, N., Docherty, F.E., Brown, H.K. et al. (7 more authors) (2014) Prostate Cancer Cells Preferentially Home to Osteoblast-rich Areas in the Early Stages of Bone Metastasis: Evidence From In Vivo Models. Journal of Bone and Mineral Research , 29 (12). pp. 2688-2696. ISSN 0884-0431

Ottewell, P.D., Wang, N. orcid.org/0000-0002-2663-7515, Brown, H.K. et al. (5 more authors) (2014) Zoledronic Acid Has Differential Antitumor Activity in the Pre- and Postmenopausal Bone Microenvironment In Vivo. Clinical Cancer Research, 20 (11). pp. 2922-2932. ISSN 1078-0432

Dougall, W.C., Holen, I. orcid.org/0000-0002-8759-6913 and González Suárez, E. (2014) Targeting RANKL in metastasis. Bonekey Rep, 3. 519. ISSN 2047-6396

Eccles, S.A., Aboagye, E.O., Ali, S. et al. (84 more authors) (2013) Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15. R92. ISSN 1465-5411

Brown, H.K., Ottewell, P.D., Evans, C.A. et al. (2 more authors) (2012) A single administration of combination therapy inhibits breast tumour progression in bone and modifies both osteoblasts and osteoclasts. Journal of Bone Oncology, 1. pp. 47-56. ISSN 2212-1374

Holen, I., Whitworth, J., Nutter, F. et al. (6 more authors) (2012) Loss of plakoglobin promotes decreased cell-cell contact, increased invasion, and breast cancer cell dissemination in vivo. Breast Cancer Research, 14. R86 . ISSN 1465-5411

Brown, H.K., Ottewell, P.D., Coleman, R.E. et al. (1 more author) (2011) The kinetochore protein Cenp-F is a potential novel target for zoledronic acid in breast cancer cells. Journal of Cellular and Molecular Medicine, 15 (3). 501 - 513. ISSN 1582-1838

Wind, N.S. and Holen, I. orcid.org/0000-0002-8759-6913 (2011) Multidrug Resistance in Breast Cancer: From In Vitro Models to Clinical Studies. International Journal of Breast Cancer, 2011. 967419. ISSN 2090-3170

Holen, I. orcid.org/0000-0002-8759-6913 and Coleman, R.E. orcid.org/0000-0002-4275-1043 (2010) Anti-tumour activity of bisphosphonates in preclinical models of breast cancer. Breast Cancer Research, 12. 214. ISSN 1465-5411

Coleman, R.E. orcid.org/0000-0002-4275-1043, Lipton, A., Roodman, G.D. et al. (11 more authors) (2010) Metastasis and bone loss: Advancing treatment and prevention. Cancer Treatment Reviews, 36 (8). pp. 615-620. ISSN 0305-7372

Coscia, M., Quaglino, E., Iezzi, M. et al. (11 more authors) (2010) Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. Journal of Cellular and Molecular Medicine, 14 (12). pp. 2803-2815. ISSN 1582-1838

Neville-Webbe, H.L., Coleman, R.E. orcid.org/0000-0002-4275-1043 and Holen, I. orcid.org/0000-0002-8759-6913 (2010) Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction. British Journal of Cancer, 102. pp. 1010-1017. ISSN 0007-0920

Reid, P.E., Brown, N.J. and Holen, I. (2009) Breast cancer cells stimulate osteoprotegerin (OPG) production by endothelial cells through direct cell contact. Molecular Cancer, 8 (49). ISSN 1476-4598

Xue, X.Y., Teare, M.D., Holen, I. et al. (2 more authors) (2009) Optimizing the yield and utility of circulating cell-free DNA from plasma and serum. Clinica Chimica Acta, 404 (2). pp. 100-104. ISSN 0009-8981

Thompson, A., Brennan, K., Cox, A. et al. (9 more authors) (2008) Evaluation of the current knowledge limitations in breast cancer research: a gap analysis. Breast Cancer Research, 10 (2). ISSN 1465-5411

Conference or Workshop Item

Ottewell, P.D., Lefley, D.V., Coleman, R.E. et al. (1 more author) (2008) Mechanisms of apoptosis and cell-cycle arrest in subcutaneous breast tumours treated sequentially with doxorubicin followed by zoledronic acid. In: Breast Cancer Research 2008, 13 May 2008, London, UK.

Lefley, D.V., Holen, I., Coleman, R.E. et al. (1 more author) (2008) Pretreatment of breast cancer cells with doxorubicin facilitates the subsequent uptake of zoledronic acid. In: Breast Cancer Research 2008, May 2008, London, UK.

Holen, I., Neville-Webbe, H. and Coleman, R.E. (2006) Benefits of combined treatments using antiresorptive agents and cytotoxic drugs. In: Breast cancer research: the past and the future, 1 November 2006, London, UK.

Michailidou, M., Brown, N., Coleman, R.E. et al. (1 more author) (2006) Effects of combined treatment with Zometa and Taxol on endothelial cells in vitro. In: Breast cancer research: the past and the future, 1 November 2006, London, UK.

Ottewell, P.D., Jones, M., Coleman, R.E. et al. (1 more author) (2006) Synergistic effects of cytotoxic drugs and antiresorptive agents in vitro and in vivo. In: Breast cancer research: the past and the future, 1 November 2006, London, UK.

Proceedings Paper

Lefley, D., Nutter, F., Brown, H. et al. (7 more authors) (2017) Human specific models for studying ER plus ve and ER- ve breast cancer bone metastasis. In: Clinical and Experimental Metastasis. EACR seed and soil: in vivo models of metastasis conference, 27-29 Nov 2017, Berlin, Germany . Springer Verlag , p. 516.