Items where authors include "Heath, P.R."

Article

Khan, N.L.A., Muhandiram, S., Dissanayake, K. et al. (7 more authors) (2024) Effect of 3D and 2D cell culture systems on trophoblast extracellular vesicle physico-chemical characteristics and potency. Frontiers in Cell and Developmental Biology, 12. 1382552. ISSN 2296-634X

Almansouri, T., Waller, R. orcid.org/0000-0001-5815-8829, Wharton, S.B. orcid.org/0000-0003-2785-333X et al. (5 more authors) (2024) The microglial transcriptome of age-associated deep subcortical white matter lesions suggests a neuroprotective response to blood–brain barrier dysfunction. International Journal of Molecular Sciences, 25 (8). 4445. ISSN 1422-0067

Griffin, J. orcid.org/0000-0003-3969-7637, Down, J., Quayle, L.A. et al. (10 more authors) (2024) Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial. The Journal of Pathology: Clinical Research, 10 (2). e12363. ISSN 2056-4538

Waller, R. orcid.org/0000-0001-5815-8829, Bury, J.J., Appleby-Mallinder, C. et al. (10 more authors) (2024) Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival. Brain Communications, 6 (1). fcad331. ISSN 2632-1297

Waller, R. orcid.org/0000-0001-5815-8829, Hase, Y., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (4 more authors) (2023) Transcriptomic profiling reveals discrete poststroke dementia neuronal and gliovascular signatures. Translational Stroke Research, 14 (3). pp. 383-396. ISSN 1868-601X

Allen, S.P. orcid.org/0000-0003-4418-7375, Al Sultan, A., Kabucho Kibirige, E. et al. (13 more authors) (2023) A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations. Frontiers in Aging Neuroscience, 15. 1151848. ISSN 1663-4365

Godakumara, K., Heath, P.R. orcid.org/0000-0002-8385-1438 and Fazeli, A. (2023) Rhythm of the first language: dynamics of extracellular vesicle-based embryo–maternal communication in the pre-implantation microenvironment. International Journal of Molecular Sciences, 24 (7). 6811. ISSN 1422-0067

Bazaz, R., Marriott, H.M., Wright, C. et al. (7 more authors) (2023) Transient increase in atherosclerotic plaque macrophage content following Streptococcus pneumoniae pneumonia in ApoE-deficient mice. Frontiers in Cellular and Infection Microbiology, 13. ISSN 2235-2988

Hart, A.R., Khan, N.L.A., Dissanayake, K. et al. (5 more authors) (2023) The extracellular vesicles proteome of endometrial cells simulating the receptive menstrual phase differs from that of endometrial cells simulating the non-receptive menstrual phase. Biomolecules, 13 (2). 279. ISSN 2218-273X

Liaqat Ali Khan, N. orcid.org/0000-0001-7781-0552, Nafee, T., Shao, T. et al. (5 more authors) (2022) Dysregulation in multiple transcriptomic endometrial pathways is associated with recurrent implantation failure and recurrent early pregnancy loss. International Journal of Molecular Sciences, 23 (24). 16051. ISSN 1661-6596

Lacey, J., Webster, S.J., Heath, P.R. et al. (7 more authors) (2022) Sorting Nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes. Haematologica, 107 (8). pp. 1902-1913. ISSN 0390-6078

Vázquez-Villaseñor, I., Smith, C.I., Thang, Y.J.R. et al. (5 more authors) (2022) RNA-Seq profiling of neutrophil-derived microvesicles in Alzheimer’s disease patients identifies a miRNA signature that may impact blood–brain barrier integrity. International Journal of Molecular Sciences, 23 (11). 5913.

Lättekivi, F., Guljavina, I., Midekessa, G. et al. (7 more authors) (2022) Profiling blood serum extracellular vesicles in plaque psoriasis and psoriatic arthritis patients reveals potential disease biomarkers. International Journal of Molecular Sciences, 23 (7). 4005. ISSN 1422-0067

Vazquez‐Villasenor, I., Garwood, C.J., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (3 more authors) (2021) Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function. European Journal of Neuroscience, 54 (9). pp. 6987-7005. ISSN 0953-816X

Giovannelli, I., Bayatti, N., Brown, A. et al. (23 more authors) (2021) Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2. Brain Communications, 3 (3). fcab141. ISSN 2632-1297

Castelli, L.M., Cutillo, L., Souza, C.D.S. et al. (14 more authors) (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16 (1). 53.

Waller, R. orcid.org/0000-0001-5815-8829, Narramore, R., Simpson, J.E. orcid.org/0000-0002-3753-4271 et al. (12 more authors) (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to alzheimer’s and small vessel disease pathologies. Brain Pathology, 31 (3). e12928. ISSN 1015-6305

Parker, V.L., Cushen, B.F., Gavriil, E. et al. (4 more authors) (2021) Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women. Molecular Medicine Reports, 23 (4). 258. ISSN 1791-2997

Ashford, B.A. orcid.org/0000-0002-9247-3125, Boche, D., Cooper‐Knock, J. et al. (3 more authors) (2021) Review: Microglia in motor neuron disease. Neuropathology and Applied Neurobiology, 47 (2). pp. 179-197. ISSN 0305-1846

Appleby‐Mallinder, C., Schaber, E., Kirby, J. orcid.org/0000-0002-7468-5917 et al. (4 more authors) (2021) TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis. Neuropathology and Applied Neurobiology, 47 (1). pp. 61-72. ISSN 0305-1846

Bury, J.J., Chambers, A., Heath, P.R. et al. (6 more authors) (2021) Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9 (1). 5.

Crooks, L., Cooper-Knock, J. orcid.org/0000-0002-0873-8689, Heath, P.R. et al. (8 more authors) (2020) Identification of single nucleotide variants in the Moroccan population by whole-genome sequencing. BMC Genetics, 21 (1). 111.

Fadul, M.M. orcid.org/0000-0002-2208-9988, Heath, P.R., Cooper-Knock, J. orcid.org/0000-0002-0873-8689 et al. (8 more authors) (2020) Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 7924. ISSN 1661-6596

Allen, S.P., Seehra, R.S., Heath, P.R. et al. (6 more authors) (2020) Transcriptomic analysis of human astrocytes in vitro reveals hypoxia-induced mitochondrial dysfunction, modulation of metabolism, and dysregulation of the immune response. International Journal of Molecular Sciences, 21 (21). 8028. ISSN 1422-0067

Chambers, A., Bury, J.J., Minett, T. et al. (9 more authors) (2020) Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79 (9). pp. 950-958. ISSN 0022-3069

Ord, J., Heath, P.R. orcid.org/0000-0002-8385-1438, Fazeli, A. orcid.org/0000-0003-0870-9914 et al. (1 more author) (2020) Paternal effects in a wild‐type zebrafish implicate a role of sperm‐derived small RNAs. Molecular Ecology, 29 (14). pp. 2722-2735. ISSN 0962-1083

Weinreich, M., Shepheard, S., Verber, N. et al. (5 more authors) (2020) Neuropathological characterisation of a novel TBK1 loss of function mutation associated with amyotrophic lateral sclerosis. Neuropathology & Applied Neurobiology, 46 (3). pp. 279-291. ISSN 0305-1846

Vazquez-Villaseñor, I., Garwood, C.J., Heath, P.R. et al. (3 more authors) (2020) Expression of p16 and p21 in the frontal association cortex of ALS/MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease. Neuropathology and Applied Neurobiology, 46 (2). pp. 171-185. ISSN 0305-1846

Fadul, M.M. orcid.org/0000-0002-2208-9988, Garwood, C.J., Waller, R. orcid.org/0000-0001-5815-8829 et al. (6 more authors) (2020) NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21 (1). 340. ISSN 1661-6596

Allen, S.P., Hall, B., Woof, R. et al. (16 more authors) (2019) C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis. Brain. 302. pp. 1-20. ISSN 0006-8950

Ajikumar, A., Long, M.B., Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (4 more authors) (2019) Neutrophil-derived microvesicle induced dysfunction of brain microvascular endothelial cells in vitro. International Journal of Molecular Sciences, 20 (20). 5227. ISSN 1661-6596

Goodall, E.F., Leach, V., Wang, C. et al. (8 more authors) (2019) Age-associated mRNA and miRNA expression changes in the blood-brain barrier. International Journal of Molecular Sciences, 20 (12). 3097. ISSN 1661-6596

Tulotta, C., Lefley, D.V., Freeman, K. et al. (16 more authors) (2019) Endogenous production of IL-1B by breast cancer cells drives metastasis and colonisation of the bone microenvironment. Clinical Cancer Research, 25 (9). pp. 2769-2782. ISSN 1078-0432

Cooper-Knock, J., Moll, T., Ramesh, T. et al. (26 more authors) (2019) Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis. Cell Reports, 26 (9). 2298-2306.e5. ISSN 2211-1247

Varcianna, A.E., Myszczynska, M.A., Castelli, L.M. et al. (9 more authors) (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine, 40. pp. 626-635. ISSN 2352-3964

Ratcliffe, L.E., Vázquez Villaseñor, I., Jennings, L. et al. (8 more authors) (2018) Loss of IGF1R in human astrocytes alters complex I activity and support for neurons. Neuroscience, 390. pp. 46-59. ISSN 0306-4522

Iannitti, T., Scarrott, J., Likhite, S. et al. (12 more authors) (2018) Translating SOD1 gene silencing towards the clinic: A highly efficacious, off-target free and biomarker-supported strategy for familial ALS. Molecular Therapy : Nucleic Acids, 12. pp. 75-88. ISSN 2162-2531

Frith, T.J.R. orcid.org/0000-0002-6078-5466, Granata, I., Wind, M. et al. (16 more authors) (2018) Human axial progenitors generate trunk neural crest cells in vitro. eLife, 7. e35786. ISSN 2050-084X

Abu-Duhier, F., Pooranachandran, V., McDonagh, A.J.G. et al. (5 more authors) (2018) Whole genome sequencing in an acrodermatitis enteropathica family from the Middle East. Dermatology Research and Practice, 2018. 1284568. ISSN 1687-6105

Morgan, S.V., Garwood, C.J., Jennings, L. et al. (10 more authors) (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47 (12). pp. 1444-1456. ISSN 0953-816X

Shelkovnikova, T.A. orcid.org/0000-0003-1367-5309, Kukharsky, M.S., An, H. et al. (5 more authors) (2018) Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 13 (1). 30. ISSN 1750-1326

Goodall, E.F., Wang, C., Simpson, J.E. et al. (6 more authors) (2018) Age-associated changes in the blood brain barrier: Comparative studies in human and mouse. Neuropathology and Applied Neurobiology, 44 (3). pp. 328-340. ISSN 0305-1846

Waller, R. orcid.org/0000-0001-5815-8829, Wyles, M., Heath, P.R. et al. (4 more authors) (2018) Small RNA sequencing of sporadic amyotrophic lateral sclerosis cerebrospinal fluid reveals differentially expressed miRNAs related to neural and glial activity. Frontiers in Neuroscience, 11. 731. ISSN 1662-4548

Salman, M.M., Kitchen, P., Woodroofe, M.N. et al. (4 more authors) (2017) Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia. Frontiers in Cellular Neuroscience, 11. 386. ISSN 1662-5102

Ameen-Ali, K.E., Wharton, S.B., Simpson, J.E. et al. (3 more authors) (2017) Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease. Neuropathology and Applied Neurobiology, 43 (7). pp. 553-570. ISSN 0305-1846

Waller, R. orcid.org/0000-0001-5815-8829, Goodall, E.F., Milo, M. et al. (8 more authors) (2017) Serum miRNAs miR-206, 143-3p and 374b-5p as potential biomarkers for amyotrophic lateral sclerosis (ALS). Neurobiology of Aging, 55. pp. 123-131. ISSN 0197-4580

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2017) Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role. Neuropathology and Applied Neurobiology, 43 (4). pp. 281-298. ISSN 1365-2990

Tu, W.Y., Simpson, J.E., Highley, J.R. et al. (1 more author) (2017) Spinal muscular atrophy: Factors that modulate motor neurone vulnerability. Neurobiology of Disease, 102. pp. 11-20. ISSN 0969-9961

Boyd, P.J., Tu, W.Y. orcid.org/0000-0002-2671-471X, Shorrock, H.K. et al. (14 more authors) (2017) Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy. PLoS Genetics, 13 (4). e1006744. ISSN 1553-7390

Stopford, M.J., Higginbottom, A., Hautbergue, G.M. et al. (14 more authors) (2017) C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. Human Molecular Genetics, 26 (6). pp. 1133-1145. ISSN 0964-6906

Waller, R., Woodroofe, M.N., Wharton, S.B. et al. (8 more authors) (2016) Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role. Journal of Neuroimmunology, 299. pp. 139-146. ISSN 1872-8421

Nardo, G., Trolese, M.C., de Vito, G. et al. (8 more authors) (2016) Immune response in peripheral axons delays disease progression in SOD1(G93A) mice. Journal of Neuroinflammation, 13 (1). p. 261. ISSN 1742-2094

Garwood, C.J., Ratcliffe, L.E., Simpson, J.E. et al. (3 more authors) (2016) Review: Astrocytes in Alzheimer's disease and other age-associated dementias; a supporting player with a central role. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Heath, P.R., Appleby-Mallinder, C., Wyles, M.D. et al. (3 more authors) (2016) Expression microdissection isolation of enriched cell populations from archival brain tissue. Journal of Neuroscience Methods. ISSN 0165-0270

Fluteau, A., Ince, P.G., Minett, T. et al. (10 more authors) (2015) The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain. Neuroscience Letters, 609. pp. 11-17. ISSN 0304-3940

Baker, D.J., Blackburn, D.J., Keatinge, M. et al. (6 more authors) (2015) Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience, 9. 410. ISSN 1662-5102

Cookson, V.J., Waite, S.L., Heath, P.R. et al. (3 more authors) (2015) Binding loci of RelA-containing nuclear factor-kappaB dimers in promoter regions of PHM1-31 myometrial smooth muscle cells. Molecular Human Reproduction, 21 (11). pp. 865-883. ISSN 1360-9947

Al-Mashhadi, S., Simpson, J.E., Heath, P.R. et al. (6 more authors) (2015) Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. Brain Pathology, 25 (5). pp. 565-574. ISSN 1015-6305

Garwood, C.J., Ratcliffe, L.E., Morgan, S.V. et al. (7 more authors) (2015) Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Molecular Brain, 8. 51 . ISSN 1756-6606

Simpson, J.E., Ince, P.G., Minett, T. et al. (9 more authors) (2015) Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathology and Applied Neurobiology. ISSN 0305-1846

Simpson, J.E., Ince, P.G., Matthews, F.E. et al. (7 more authors) (2015) A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathology and Applied Neurobiology, 41 (4). pp. 483-496. ISSN 0305-1846

Cooper-Knock, J., Bury, J.J., Heath, P.R. et al. (8 more authors) (2015) C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis. PLoS One, 10 (5). e0127376 . ISSN 1932-6203

Viphakone, N., Cumberbatch, M.G., Livingstone, M.J. et al. (4 more authors) (2015) Luzp4 defines a new mRNA export pathway in cancer cells. Nucleic Acids Research, 43 (4). pp. 2353-2366. ISSN 0305-1048

Raman, R., Allen, S.P., Goodall, E.F. et al. (11 more authors) (2015) Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions. Neuropathology and Applied Neurobiology, 41 (2). pp. 201-226. ISSN 0305-1846

Asi, Y.T., Simpson, J.E. orcid.org/0000-0002-3753-4271, Heath, P.R. orcid.org/0000-0002-8385-1438 et al. (5 more authors) (2014) Alpha-synuclein mRNA expression in oligodendrocytes in MSA. Glia, 62 (6). pp. 964-970. ISSN 0894-1491

Green, N.H., Nicholls, Z., Heath, P.R. et al. (4 more authors) (2014) Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa. International Journal of Experimental Pathology, 95 (3). 216 - 228. ISSN 0959-9673

Heath, P.R., Kirby, J. and Shaw, P.J. (2013) Investigating cell death mechanisms in amyotrophic lateral sclerosis using transcriptomics. Frontiers in Cellular Neuroscience, 7. 259. ISSN 1662-5102

Goodall, E.F., Heath, P.R., Bandmann, O. et al. (2 more authors) (2013) Neuronal dark matter: the emerging role of microRNAs in neurodegeneration. Frontiers in Cellular Neuroscience, 7. 178. ISSN 1662-5102

Richardson, K., Allen, S.P., Mortiboys, H.J. et al. (5 more authors) (2013) The Effect of SOD1 Mutation on Cellular Bioenergetic Profile and Viability in Response to Oxidative Stress and Influence of Mutation-Type. PLoS ONE, 8 (6). e68256. ISSN 1932-6203

Brockington, A., Ning, K., Heath, P.R. et al. (7 more authors) (2013) Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity. Acta Neuropathologica, 125 (1). pp. 95-109. ISSN 0001-6322

Alminana, C., Heath, P.R. orcid.org/0000-0002-8385-1438, Wilkinson, S. et al. (9 more authors) (2012) Early developing pig embryos mediate their own environment in the maternal tract. PLOS ONE, 7 (3). e33625.

Kirby, J., Ning, K., Ferraiuolo, L. et al. (10 more authors) (2011) Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain, 134 (2). pp. 506-517. ISSN 0006-8950

Ward, J.R., Heath, P.R., Catto, J.W. et al. (3 more authors) (2011) Regulation of neutrophil senescence by microRNAs. Plos One, 6 (1). Art no.e15810. ISSN 1932-6203

Brockington, A., Heath, P.R., Holden, H. et al. (7 more authors) (2010) Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis. BMC Genomics, 11. Art no.203. ISSN 1471-2164

Cox, L.E., Ferraiuolo, L., Goodall, E.F. et al. (13 more authors) (2010) Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). Plos One, 5 (3). Art no.e9872. ISSN 1932-6203