Items where authors include "Fishwick, CWG"

Article

Grossman, S, Fishwick, CWG and McPhillie, MJ orcid.org/0000-0001-8264-8211 (2023) Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV. Pharmaceuticals, 16 (2). 261. ISSN 1424-8247

Orritt, KM, Feng, L, Newell, JF et al. (9 more authors) (2022) De novo design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region. RSC Medicinal Chemistry, 13 (7). pp. 831-839. ISSN 2632-8682

Turvey, SJ orcid.org/0000-0003-4298-8339, McPhillie, MJ orcid.org/0000-0001-8264-8211, Kearney, MT et al. (3 more authors) (2022) Recent Developments in the Structural Characterisation of the IR and IGF1R: Implications for the Design of IR-IGF1R Hybrid Receptor Modulators. RSC Medicinal Chemistry, 2022 (4). pp. 360-374. ISSN 2632-8682

Turner, LD, Trinh, CH orcid.org/0000-0002-5087-5011, Hubball, RA et al. (5 more authors) (2022) From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. Journal of Medicinal Chemistry, 65 (2). pp. 1481-1504. ISSN 0022-2623

Orritt, KM, Maxwell, A, Fishwick, CWG orcid.org/0000-0003-1283-2181 et al. (1 more author) (2021) Exploitation of a novel allosteric binding region in DNA gyrase and its implications for antibacterial drug discovery. Future Medicinal Chemistry. ISSN 1756-8919

Lang, PA, Parkova, A, Leissing, TM et al. (10 more authors) (2020) Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli. Biomolecules, 10 (6). 899. p. 899. ISSN 2218-273X

McPhillie, MJ orcid.org/0000-0001-8264-8211, Zhou, Y, Hickman, MR et al. (31 more authors) (2020) Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites. Frontiers in Cellular and Infection Microbiology, 10. 203. ISSN 2235-2988

Cole, BA orcid.org/0000-0002-6214-016X, Johnson, RM, Dejakaisaya, H et al. (4 more authors) (2020) Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel. iScience, 23 (5). 101100. ISSN 2589-0042

King, RJ, Schuett, K, Tiede, C orcid.org/0000-0003-0280-4005 et al. (10 more authors) (2020) Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk. Haematologica. ISSN 0390-6078

Johansson, NG, Turku, A, Vidilaseris, K et al. (14 more authors) (2020) Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment. ACS Medicinal Chemistry Letters. ISSN 1948-5875

Cain, R, Salimraj, R, Punekar, AS et al. (8 more authors) (2019) Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase. Journal of Medicinal Chemistry, 62 (21). pp. 9703-9717. ISSN 0022-2623

Narramore, S, Stevenson, CEM, Maxwell, A et al. (2 more authors) (2019) New insights into the binding mode of pyridine-3-carboxamide inhibitors of E. coli DNA gyrase. Bioorganic and Medicinal Chemistry, 27 (16). pp. 3546-3550. ISSN 0968-0896

Cahill, ST, Tyrrell, JM, Navratilova, IH et al. (10 more authors) (2019) Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates. Biochimica et biophysica acta. General subjects, 1863 (4). pp. 742-748. ISSN 0304-4165

Oldknow, S orcid.org/0000-0002-7506-0062, Rota Martir, D, Pritchard, VE orcid.org/0000-0001-5270-4534 et al. (4 more authors) (2018) Structure-switching M₃L₂ Ir(III) coordination cages with photo-isomerising azo-aromatic linkers. Chemical Science. pp. 8150-8159. ISSN 2041-6520

lykins, JD, Filippova, E, Halavaty, AS et al. (21 more authors) (2018) CSGID Identifies Phenotypes and Solves Structures for Five Enzymes in Toxoplasma gondii. Frontiers in cellular and infection microbiology, 8. ARTN352. ISSN 2235-2988

Millington, EL, Dondas, HA, Fishwick, CWG orcid.org/0000-0003-1283-2181 et al. (2 more authors) (2018) Catalytic bimetalic [Pd(0)/Ag(I) Heck-1,3-dipolar cycloaddition cascade reactions accessing spiro-oxindoles. Concomitant in situ generation of azomethine ylides and dipolarophile. Tetrahedron, 74 (27). pp. 3564-3577. ISSN 0040-4020

Amporndanai, K, Johnson, RM, O’Neil, PM et al. (6 more authors) (2018) X-ray and cryo-EM structures of inhibitor-bound cytochrome bc₁ complexes for structure-based drug discovery. IUCrJ, 5 (2). pp. 200-210. ISSN 2052-2525

Cain, R, Brem, J, Zollman, D et al. (10 more authors) (2018) In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors. Journal of Medicinal Chemistry, 61 (3). pp. 1255-1260. ISSN 0022-2623

Robinson, JI orcid.org/0000-0001-5425-7520, Baxter, EW, Owen, RL et al. (13 more authors) (2018) Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action. Proceedings of the National Academy of Sciences, 115 (1). E72-E81. ISSN 0027-8424

Turner, LD, Summers, AJ, Johnson, LO et al. (2 more authors) (2017) Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ACS Medicinal Chemistry Letters, 8 (12). pp. 1264-1268. ISSN 1948-5875

Batson, S, de Chiara, C, Majce, V et al. (10 more authors) (2017) Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. Nature Communications, 8. 1939. ISSN 2041-1723

Calvopiña, K, Hinchliffe, P, Brem, J et al. (8 more authors) (2017) Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology, 106 (3). pp. 492-504. ISSN 0950-382X

Calvopina, K, Hinchliffe, P, Brem, J et al. (8 more authors) (2017) Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. Molecular Microbiology, 106 (3). pp. 492-504. ISSN 0950-382X

McConkey, GA orcid.org/0000-0001-6529-794X, Bedingfield, PTP, Burrell, DR et al. (5 more authors) (2017) Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes. Bioorganic and Medicinal Chemistry, 27 (16). pp. 3878-3882. ISSN 0968-0896

Rawson, S, McPhillie, MJ, Johnson, RM et al. (2 more authors) (2017) The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design. Acta Crystallographica Section D: Structural Biology, 73 (6). pp. 534-540. ISSN 2059-7983

Dilly, SJ, Clark, AJ, Marsh, A et al. (4 more authors) (2017) A Chemical Genomics Approach to Drug Reprofiling in Oncology: Antipsychotic Drug Risperidone as a Potential Adenocarcinoma Treatment. Cancer Letters, 393. pp. 16-21. ISSN 0304-3835

Cahill, ST, Cain, R, Wang, DY et al. (9 more authors) (2017) Cyclic Boronates Inhibit All Classes of β-Lactamase. Antimicrobial Agents and Chemotherapy, 61 (4). e02260-16. ISSN 0066-4804

Thorp-Greenwood, F orcid.org/0000-0001-6228-2056, Brennan, AD orcid.org/0000-0003-4196-081X, Oldknow, S orcid.org/0000-0002-7506-0062 et al. (4 more authors) (2017) Tris-N-alkylpyridinium-functionalised cyclotriguaiacylene hosts as axles in branched [4]pseudorotaxane formation. Supramolecular Chemistry, 29 (6). pp. 430-440. ISSN 1061-0278

Kaye, K, Bryant, DE, Marriott, KER et al. (3 more authors) (2016) Selective Phosphonylation of 5′-Adenosine Monophosphate (5′-AMP) via Pyrophosphite [PPi(III)]. Origins of Life and Evolution of Biospheres, 46 (4). pp. 1-10. ISSN 0169-6149

Brem, J, Cain, R, Cahill, S et al. (7 more authors) (2016) Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications, 7. 12406. ISSN 2041-1723

McPhillie, M, Zhou, Y, El Bissatai, K et al. (36 more authors) (2016) New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports, 6. 29179. ISSN 2045-2322

Dondas, HA, Hempshall, A, Narramore, S et al. (3 more authors) (2016) γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades. Tetrahedron, 72 (10). pp. 1316-1329. ISSN 0040-4020

Naylor, J, Minard, A, Gaunt, HJ et al. (17 more authors) (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. British Journal of Pharmacology, 173 (3). pp. 562-574. ISSN 0007-1188

Grigg, R, Elboray, EE, Akkarasamiyo, S et al. (7 more authors) (2016) A Facile Palladium Catalysed 3-Component Cascade Route to Functionalised Isoquinolinones and Isoquinolines. Chemical Communications, 52 (1). pp. 164-166. ISSN 1359-7345

Shaw, J, Harris, M and Fishwick, CWG (2015) Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease. Antiviral Research, 124. 54 - 60. ISSN 0166-3542

Latham, AM, Kankanala, J, Fishwick, CWG et al. (1 more author) (2015) Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation. Methods in Molecular Biology, 1332. pp. 121-131. ISSN 1064-3745

Lolli, M, Narramore, S, Fishwick, CWG et al. (1 more author) (2015) Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. Drug Discovery Today, 20 (8). pp. 1018-1026. ISSN 1359-6446

Kime, L orcid.org/0000-0002-1743-1136, Vincent, HA, Gendoo, DMA et al. (4 more authors) (2015) Erratum: The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family. Scientific Reports, 5. 8028. ISSN 2045-2322

Avery, CA, Pease, RJ, Smith, K et al. (4 more authors) (2015) (±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors. European Journal of Medicinal Chemistry, 98. 49 - 53. ISSN 0223-5234

Kime, L, Vincent, HA, Gendoo, DMA et al. (4 more authors) (2015) The first small-molecule inhibitors of members of the ribonuclease E family. Scientific Reports, 5. 8028. ISSN 2045-2322

Latham, AM, Kankanala, J, Fearnley, GW et al. (6 more authors) (2014) In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis. PLoS ONE, 9 (11). ARTN e110997. ISSN 1932-6203

Yule, IA, Czaplewski, LG, Pommier, S et al. (3 more authors) (2014) Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity. European Journal of Medicinal Chemistry, 86. 31 - 38. ISSN 0223-5234

Cookson, NJ, Henkelis, JJ, Ansell, RJ et al. (3 more authors) (2014) Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd6L8]12+ stella octangula cage. Dalton Transactions, 43 (15). 5657 - 5661. ISSN 1477-9226

Lloyd, AJ, Potter, NJ, Fishwick, CWG et al. (2 more authors) (2013) Adenosine Tetraphosphoadenosine Drives a Continuous ATP-Release Assay for Aminoacyl-tRNA Synthetases and Other Adenylate-Forming Enzymes. ACS Chemical Biology, 8 (10). 2157 - 2163. ISSN 1554-8937

van Berkel, SS, Brem, J, Rydzik, AM et al. (7 more authors) (2013) Assay platform for clinically relevant metallo-beta-lactamases. Journal of Medicinal Chemistry, 56 (17). 6945 - 6953. ISSN 0022-2623

Fishwick, CWG, Chadwick, J, Kellet, K et al. (4 more authors) (2013) Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. Journal of Medicinal Chemistry, 56 (5). 1843 - 1852. ISSN 0022-2623

Wacker, SJ, Jurkowski, W, Simmons, KJ orcid.org/0000-0003-4846-9097 et al. (6 more authors) (2012) Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2₍₃₎ by High-Throughput Virtual Screening and Automated Patch Clamp. ChemMedChem, 7 (10). pp. 1775-1783. ISSN 1860-7179

Dondas, HA, Fishwick, CWG orcid.org/0000-0003-1283-2181, Grigg, RE et al. (1 more author) (2004) 1, 3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin anologues. Tetrahedron, 60 (15). pp. 3473-3485. ISSN 0040-4020