Keating, C., Ewart, L., Grundy, L. et al. (2 more authors) (2014) Translational potential of a mouse in vitro bioassay in predicting gastrointestinal adverse drug reactions in Phase I clinical trials. Neurogastroenterology and Motility, 26 (7). 980 - 989.
Abstract
Motility-related gastrointestinal (GI) adverse drug reactions (GADRs) such as diarrhea and constipation are a common and deleterious feature associated with drug development. Novel biomarkers of GI function are therefore required to aid decision making on the GI liability of compounds in development.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © 2014 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | adverse drug reaction; bioassay; biomarker; gastrointestinal motility; safety pharmacology |
| Dates: |
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| Institution: | The University of Sheffield |
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
| Funding Information: | Funder Grant number BBSRC BB/g01547/1 |
| Depositing User: | Symplectic Sheffield |
| Date Deposited: | 16 Sep 2014 13:12 |
| Last Modified: | 16 Sep 2014 13:12 |
| Published Version: | http://dx.doi.org/10.1111/nmo.12349 |
| Status: | Published |
| Publisher: | Wiley |
| Refereed: | Yes |
| Identification Number: | 10.1111/nmo.12349 |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:80559 |
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