Ismail, S.D., Riou, C., Joseph, S.B. et al. (15 more authors) (2021) Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size. Clinical Infectious Diseases, 73 (8). pp. 1528-1531. ISSN 1058-4838
Abstract
Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.
Metadata
| Item Type: | Article | 
|---|---|
| Authors/Creators: | 
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| Keywords: | HIV-1, replication-competent virus, reservoir, T-cell activation | 
| Dates: | 
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| Institution: | The University of Leeds | 
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mathematics (Leeds) > Applied Mathematics (Leeds) | 
| Depositing User: | Symplectic Publications | 
| Date Deposited: | 17 Feb 2025 10:25 | 
| Last Modified: | 17 Feb 2025 10:25 | 
| Status: | Published | 
| Publisher: | Oxford University Press | 
| Identification Number: | 10.1093/cid/ciab587 | 
| Sustainable Development Goals: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:223365 | 
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