Teh, I, Romero, W, Boyle, J orcid.org/0000-0002-4219-9383 et al. (23 more authors) (2022) Validation of cardiac diffusion tensor imaging sequences: A multi-centre test-retest phantom study. NMR in Biomedicine, 35 (6). e4685. ISSN 0952-3480
Abstract
Introduction
Cardiac diffusion tensor imaging (DTI) is an emerging technique for the in vivo characterisation of myocardial microstructure, and there is a growing need for its validation and standardisation. We sought to establish accuracy, precision, repeatability and reproducibility of state-of-the-art pulse sequences for cardiac DTI between ten centres internationally.
Methods
Phantoms comprising 0-20% polyvinylpyrrolidone (PVP) were scanned with DTI using a product pulsed gradient spin echo (PGSE; N=10 sites) sequence, and a custom motion-compensated spin echo (SE; N=5) or stimulated echo (STEAM; N=5) sequence suitable for cardiac DTI in vivo. A second identical scan was performed 1-9 days post, and the data analysed centrally.
Results
The average mean diffusivities (MD) in 0% PVP were (1.124, 1.130, 1.113) × 10-3 mm2/s for PGSE, SE and STEAM respectively, and accurate to within 1.5% of reference data from literature. The coefficients of variation in MD across sites were 2.6%, 3.1%, 2.1% for PGSE, SE and STEAM, and were similar to previous studies using only PGSE. Reproducibility in MD was excellent, with mean differences in PGSE, SE and STEAM of (0.3 ± 2.3, 0.24 ± 0.95, 0.52 ± 0.58) × 10-5 mm2/s (mean ± 1.96SD).
Conclusion
We show that custom sequences for cardiac DTI provide accurate, precise, repeatable and reproducible measurements. Further work in anisotropic and/or deforming phantoms is warranted.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Cardiac DTI; multi-centre; reproducibility; isotropic phantom; polyvinylpyrrolidone; pulse sequence validation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Systems and Design (iESD) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Biomedical Imaging Science Dept (Leeds) |
Funding Information: | Funder Grant number British Heart Foundation PG/19/1/34076 British Heart Foundation PG/17/28/32943 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Jan 2022 12:41 |
Last Modified: | 02 May 2023 12:12 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/nbm.4685 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182548 |