Francis, D, Blacker, AJ orcid.org/0000-0003-4898-2712, Kapur, N orcid.org/0000-0003-1041-8390 et al. (1 more author) (2022) Readily Reconfigurable Continuous-Stirred Tank Photochemical Reactor Platform. Organic Process Research & Development, 26 (1). acs.oprd.1c00428. pp. 215-221. ISSN 1083-6160
Abstract
A new modular photochemical continuous stirred-tank reactor (CSTR) design is described, based upon the development of light-source units that can be fitted to the previously described fReactor CSTR platform. In addition to use in homogeneous photochemical reactions (e.g., photoredox-catalyzed hydroamination), these units are especially well suited to handling multiphasic mixtures, exemplified here in solid–liquid (Wohl–Ziegler bromination) and gas–liquid (photocatalytic oxidative decarboxylation) reactions. The use of slurries as input feeds allows for the intensification of photochemical brominations, while the modular nature of the system facilitates the simple integration of downstream reaction steps, exemplified here in a continuous synthesis of an intermediate for the antihypertensive drug valsartan.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 American Chemical Society. This is an author produced version of an article, published in Organic Process Research & Development. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | continuous flow reactors; photochemistry; photoredox; multiphasic |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/R511717/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jan 2022 13:17 |
Last Modified: | 22 Dec 2022 01:13 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.oprd.1c00428 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182082 |