Han, X, Bibb, R and Harris, R orcid.org/0000-0002-3425-7969 (2015) Design of bifurcation junctions in artificial vascular vessels additively manufactured for skin tissue engineering. Journal of Visual Languages & Computing, 28. pp. 238-249. ISSN 1045-926X
Abstract
Construction of an artificial vascular network ready for its additive manufacturing is an important task in tissue engineering. This paper presents a set of simple mathematical algorithms for the computer-aided design of complex three dimensional vascular networks. Firstly various existing mathematical methods from the literature are reviewed and simplified for the convenience of applications in tissue engineering. This leads to a complete and step by step method for the construction of an artificial vascular network. Secondly a systematic parametric study is presented to illustrate how the various parameters in the vascular junction model affect the key factors that have to be controlled when designing the bifurcation junctions of a vascular network. These results are presented as a set of simple design rules and a design map which serve as a convenient guide for tissue engineering researchers when constructing artificial vascular networks.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 Elsevier Ltd. This is an author produced version of a paper published in Journal of Visual Languages & Computing. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Additive manufacturing; 3D printing; Vascular network design; Bifurcation junction; Junction smoothing; Tissue engineering |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Aug 2016 13:56 |
Last Modified: | 16 Jan 2018 03:58 |
Published Version: | http://dx.doi.org/10.1016/j.jvlc.2014.12.005 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jvlc.2014.12.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:101598 |