Items where authors include "Marcotti, W."

Article

Underhill, A. orcid.org/0000-0002-6876-861X, Webb, S., Grandi, F.C. orcid.org/0000-0002-1303-6710 et al. (13 more authors) (2025) MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea. Proceedings of the National Academy of Sciences, 122 (1). e2414707122. ISSN 0027-8424

De Faveri, F. orcid.org/0000-0001-7691-5635, Ceriani, F. orcid.org/0000-0002-5366-341X and Marcotti, W. orcid.org/0000-0002-8770-7628 (2025) In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea. Nature Communications, 16. 29.

O’Connor, A.P., Amariutei, A.E., Zanella, A. et al. (9 more authors) (2024) In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic efferent innervation in inner hair cells. JCI Insight, 9 (23). e182138. ISSN 2379-3708

Conrad, L.J., Grandi, F.C. orcid.org/0000-0002-1303-6710, Carlton, A.J. et al. (6 more authors) (2024) The upregulation of K+ and HCN channels in developing spiral ganglion neurons is mediated by cochlear inner hair cells. The Journal of Physiology, 602 (20). pp. 5329-5351. ISSN 0022-3751

Hool, S.A. orcid.org/0009-0000-9896-4534, Jeng, J. orcid.org/0000-0002-6274-8597, Jagger, D.J. orcid.org/0000-0003-2796-5526 et al. (2 more authors) (2023) Age‐related changes in P2Y receptor signalling in mouse cochlear supporting cells. The Journal of Physiology, 601 (19). pp. 4375-4395. ISSN 0022-3751

Yang, Y. orcid.org/0000-0001-5560-052X, Murtha, K., Climer, L.K. orcid.org/0000-0003-0236-1822 et al. (5 more authors) (2023) Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells. The Journal of Physiology, 601 (19). pp. 4291-4308. ISSN 0022-3751

Amariutei, A.E. orcid.org/0000-0001-5803-1166, Jeng, J.-Y., Safieddine, S. et al. (1 more author) (2023) Recent advances and future challenges in gene therapy for hearing loss. Royal Society Open Science, 10 (6). 230644. ISSN 2054-5703

Carlton, A.J. orcid.org/0000-0002-1054-3901, Jeng, J. orcid.org/0000-0002-6274-8597, Grandi, F.C. orcid.org/0000-0002-1303-6710 et al. (10 more authors) (2023) A critical period of prehearing spontaneous Ca2+ spiking is required for hair-bundle maintenance in inner hair cells. The EMBO Journal, 42 (4). e112118. ISSN 0261-4189

Jeng, J-Y., Carlton, A.J. orcid.org/0000-0002-1054-3901, Goodyear, R.J. et al. (10 more authors) (2022) AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness. Molecular Therapy - Methods & Clinical Development, 26. pp. 355-370. ISSN 2329-0501

Spaiardi, P., Marcotti, W. orcid.org/0000-0002-8770-7628, Masetto, S. et al. (1 more author) (2022) Signal transmission in mature mammalian vestibular hair cells. Frontiers in Cellular Neuroscience, 16. 806913.

Lorente-Cánovas, B., Eckrich, S., Lewis, M.A. et al. (3 more authors) (2022) Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells. PLoS ONE, 17 (3). e0261530. ISSN 1932-6203

Newton, S., Kong, F., Carlton, A.J. et al. (8 more authors) (2022) Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing. PLoS Genetics, 18 (1). e1009937. ISSN 1553-7390

Manca, M., Yen, P., Spaiardi, P. et al. (5 more authors) (2021) Current response in CaV1.3–/– mouse vestibular and cochlear hair cells. Frontiers in Neuroscience, 15. 749483. ISSN 1662-4548

Hardy, K., Amariutei, A.E. orcid.org/0000-0001-5803-1166, De Faveri, F. orcid.org/0000-0001-7691-5635 et al. (3 more authors) (2021) Functional development and regeneration of hair cells in the zebrafish lateral line. The Journal of Physiology, 599 (16). pp. 3913-3936. ISSN 0022-3751

Jeng, J, Harasztosi, C, Carlton, A.J. orcid.org/0000-0002-1054-3901 et al. (8 more authors) (2021) MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia. The Journal of Physiology, 599 (7). pp. 2015-2036. ISSN 0022-3751

Carlton, A.J. orcid.org/0000-0002-1054-3901, Halford, J., Underhill, A. et al. (9 more authors) (2021) Loss of Baiap2l2 destabilizes the transducing stereocilia of cochlear hair cells and leads to deafness. The Journal of Physiology, 599 (4). pp. 1173-1198. ISSN 0022-3751

Jeng, J., Carlton, A.J. orcid.org/0000-0002-1054-3901, Johnson, S.L. et al. (4 more authors) (2021) Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea. The Journal of Physiology, 599 (1). pp. 269-287. ISSN 0022-3751

Jeng, J., Ceriani, F. orcid.org/0000-0002-5366-341X, Olt, J. et al. (5 more authors) (2020) Pathophysiological changes in inner hair cell ribbon synapses in the ageing mammalian cochlea. The Journal of Physiology, 598 (19). pp. 4339-4355. ISSN 0022-3751

Martelletti, E., Ingham, N.J., Houston, O. et al. (4 more authors) (2020) Synaptojanin2 mutation causes progressive high-frequency hearing loss in mice. Frontiers in Cellular Neuroscience, 14. 561857. ISSN 1662-5102

Jeng, J., Johnson, S.L., Carlton, A.J. orcid.org/0000-0002-1054-3901 et al. (11 more authors) (2020) Age‐related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. The Journal of Physiology, 598 (18). pp. 3891-3910. ISSN 0022-3751

Spaiardi, P., Marcotti, W. orcid.org/0000-0002-8770-7628, Masetto, S. et al. (1 more author) (2020) Exocytosis in mouse vestibular Type II hair cells shows a high‐order Ca2+ dependence that is independent of synaptotagmin‐4. Physiological Reports, 8 (14). e14509.

Boddy, S.L., Romero-Guevara, R., Ji, A.-R. et al. (4 more authors) (2020) Generation of otic lineages from integration-free human-induced pluripotent stem cells reprogrammed by mRNAs. Stem Cells International, 2020. 3692937. ISSN 1687-966X

Spaiardi, P., Tavazzani, E., Manca, M. et al. (7 more authors) (2020) K+ accumulation and clearance in the calyx synaptic cleft of type I mouse vestibular hair cells. Neuroscience, 426. pp. 69-86. ISSN 0306-4522

Jeng, J., Ceriani, F. orcid.org/0000-0002-5366-341X, Hendry, A. et al. (5 more authors) (2020) Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea. The Journal of Physiology, 598 (1). pp. 151-170. ISSN 0022-3751

Dunbar, L.A., Patni, P., Aguilar, C. et al. (29 more authors) (2019) Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function. EMBO Molecular Medicine, 11 (9). ISSN 1757-4676

Bardhan, T., Jeng, J-Y. orcid.org/0000-0002-6274-8597, Waldmann, M. et al. (6 more authors) (2019) Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea. Journal of Physiology, 597 (13). pp. 3389-3406. ISSN 0022-3751

Ceriani, F. orcid.org/0000-0002-5366-341X, Hendry, A., Jeng, J.Y. orcid.org/0000-0002-6274-8597 et al. (9 more authors) (2019) Coordinated calcium signalling in cochlear sensory and non‐sensory cells refines afferent innervation of outer hair cells. The EMBO Journal, 38 (9). e99839. ISSN 1460-2075

Chessum, L., Matern, M.S., Kelly, M.C. et al. (20 more authors) (2018) Helios is a key transcriptional regulator of outer hair cell maturation. Nature, 563 (7733). pp. 696-700. ISSN 0028-0836

Corns, L.F., Johnson, S.L., Roberts, T. et al. (10 more authors) (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature Communications, 9 (1). 4015.

Spaiardi, P., Tavazzani, E., Manca, M. et al. (6 more authors) (2017) An allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular Type I hair cells. The Journal of Physiology, 595 (21). pp. 6735-6750. ISSN 0022-3751

Corns, L.F. orcid.org/0000-0003-1139-3527, Jeng, J.-Y., Richardson, G.P. et al. (2 more authors) (2017) TMC2 Modifies Permeation Properties of the Mechanoelectrical Transducer Channel in Early Postnatal Mouse Cochlear Outer Hair Cells. Frontiers in Molecular Neuroscience , 10. 326.

Sheets, L., He, X.J., Olt, J. et al. (9 more authors) (2017) Enlargement of ribbons in zebrafish hair cells increases calcium currents, but disrupts afferent spontaneous activity and timing of stimulus onset. Journal of Neuroscience. ISSN 0270-6474

Erickson, T. orcid.org/0000-0002-0910-2535, Morgan, C.P, Olt, J. et al. (9 more authors) (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife, 6.

Johnson, S.L., Olt, J., Cho, S. et al. (2 more authors) (2017) The coupling between Ca2+ channels and the exocytotic Ca2+ sensor at hair cell ribbon synapses varies tonotopically along the mature cochlea. Journal of Neuroscience. 2867-16. ISSN 0270-6474

Johnson, S.L., Ceriani, F. orcid.org/0000-0002-5366-341X, Houston, O. et al. (6 more authors) (2017) Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea. Journal of Neuroscience, 37 (2). pp. 258-268. ISSN 1529-2401

Olt, J., Allen, C.E. and Marcotti, W. orcid.org/0000-0002-8770-7628 (2016) In vivo physiological recording from the lateral line of juvenile zebrafish. Journal of Physiology, 594 (19). pp. 5427-5438. ISSN 0022-3751

Marcotti, W. orcid.org/0000-0002-8770-7628, Corns, L.F. orcid.org/0000-0003-1139-3527, Goodyear, R.J. et al. (5 more authors) (2016) The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI. Journal of Physiology, 594 (13). pp. 3667-3681. ISSN 0022-3751

Buniello, A., Ingham, N.J., Lewis, M.A. et al. (12 more authors) (2016) Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing. EMBO Molecular Medicine, 8 (3). pp. 191-207. ISSN 1757-4676

Corns, L.F. orcid.org/0000-0003-1139-3527 and Marcotti, W. orcid.org/0000-0002-8770-7628 (2016) Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells. Physiological Reports, 4 (3). e12701-e12701. ISSN 2051-817X

Corns, L.F. orcid.org/0000-0003-1139-3527, Johnson, S.L. orcid.org/0000-0003-3355-650X, Kros, C.J. et al. (1 more author) (2016) Tmc1 Point Mutation Affects Ca2+ Sensitivity and Block by Dihydrostreptomycin of the Mechanoelectrical Transducer Current of Mouse Outer Hair Cells. Journal of Neuroscience, 36 (2). pp. 336-349. ISSN 0270-6474

Taylor, R., Bullen, A., Johnson, S.L. et al. (5 more authors) (2015) Absence of plastin 1 causes abnormal maintenance of hair cell stereocilia and a moderate form of hearing loss in mice. Human Molecular Genetics, 24 (1). pp. 37-49. ISSN 0964-6906

Zampini, V., Johnson, S.L., Franz, C. et al. (6 more authors) (2014) Fine Tuning of Ca(V)1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea. PLOS ONE, 9 (11). ARTN e113750. ISSN 1932-6203

Marcotti, W., Corns, L.F., Desmonds, T. et al. (3 more authors) (2014) Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel. The Journal of Neuroscience, 34 (16). 5505 - 5514. ISSN 0270-6474

Johnson, S.L., Wedemeyer, C., Vetter, D.E. et al. (4 more authors) (2013) Cholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses. Open Biology, 3 (11). 130163. ISSN 2046-2441

Zampini, V., Johnson, S.L., Franz, C. et al. (5 more authors) (2013) Burst activity and ultrafast activation kinetics of Ca(V)1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses. Journal of Physiology, 591 (16). pp. 3811-3820. ISSN 0022-3751

Chen, W., Jongkamonwiwat, N., Abbas, L. et al. (9 more authors) (2012) Restoration of auditory evoked responses by human ES-cell-derived otic progenitors. Nature, 490 (7419). pp. 278-282. ISSN 0028-0836

Eckrich, T., Varakina, K., Johnson, S.L. et al. (6 more authors) (2012) Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells. PLoS ONE, 7 (9). e45732. ISSN 1932-6203

Kuhn, S., Ingham, N., Pearson, S. et al. (4 more authors) (2012) Auditory Function in the Tc1 Mouse Model of Down Syndrome Suggests a Limited Region of Human Chromosome 21 Involved in Otitis Media. PLoS One, 7 (2). e31433.

Johnson, S.L., Eckrich, T., Kuhn, S. et al. (8 more authors) (2011) Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells. Nature Neuroscience , 14 (6). pp. 711-717. ISSN 1097-6256

Alagramam, K.N., Goodyear, R.J., Geng, R.S. et al. (5 more authors) (2011) Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells. PLoS ONE, 6 (4). e19183. ISSN 1932-6203

Zampini, V., Ruettiger, L., Johnson, S.L. et al. (11 more authors) (2011) Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells. PLoS Biology, 9 (4). Art no. e1001048 . ISSN 1544-9173

Johnson, S.L. orcid.org/0000-0003-3355-650X, Franz, C., Kuhn, S. et al. (9 more authors) (2010) Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. Nature Neuroscience, 13 (1). pp. 45-52. ISSN 1097-6256

Johnson, S.L., Forge, A., Knipper, M. et al. (2 more authors) (2008) Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses. The Journal of Neuroscience, 28 (30). pp. 7670-7678. ISSN 1529-2401

Johnson, S.L. and Marcotti, W. (2008) Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells. Journal of Physiology, 586 (4). pp. 1029-1042. ISSN 1469-7793

Johnson, S.L., Adelman, J.P. and Marcotti, W. (2007) Genetic deletion of SK2 channels in mouse inner hair cells prevents the developmental linearization in the Ca2+ dependence of exocytosis. The Journal of Physiology, 583 (2). pp. 631-646. ISSN 0022-3751

Marcotti, W., Erven, A., Johnson, S.L. et al. (2 more authors) (2006) Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. The Journal of Physiology, 574 (3). pp. 677-698. ISSN 0022-3751

Marcotti, W., Van Netten, S.M. and Kros, C.J. (2005) The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano -electrical transducer channels. The Journal of Physiology, 567 (2). pp. 505-521. ISSN 0022-3751

Johnson, S.L., Marcotti, W. and Kros, C.J. (2005) Increase in efficiency and reduction in Ca2+ dependence of exocytosis during development of mouse inner hair cells. The Journal of Physiology, 563 (1). pp. 177-191. ISSN 0022-3751

Marcotti, W., Johnson, S.L. and Kros, C.J. (2004) A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells. The Journal of Physiology, 560 (3). pp. 691-708. ISSN 0022-3751

Marcotti, W., Johnson, S.L. and Kros, C.J. (2004) Effects of intracellular stores and extracellular Ca2+ on Ca2+-activated K+ currents in mature mouse inner hair cells. The Journal of Physiology, 557 (2). pp. 613-633. ISSN 0022-3751

Marcotti, W., Johnson, S.L., Rüsch, A. et al. (1 more author) (2003) Sodium and calcium currents shape action potentials in immature mouse inner hair cells. The Journal of Physiology, 552 (3). pp. 743-761. ISSN 0022-3751

Gale, J.E., Marcotti, W., Kennedy, H.J. et al. (2 more authors) (2001) FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel. The Journal of Neuroscience, 21 (18). pp. 7013-7025. ISSN 1529-2401

Lawlor, P., Marcotti, W., Rivolta, M.N. et al. (2 more authors) (1999) Differentiation of mammalian vestibular hair cells from conditionally immortal, postnatal supporting cells. The Journal of Neuroscience, 19 (21). pp. 9445-9458. ISSN 1529-2401