Items where authors include "Ferraiuolo, L."

Article

Harvey, C., Weinreich, M. orcid.org/0009-0003-1576-3385, Lee, J.A.K. orcid.org/0000-0001-9843-6475 et al. (22 more authors) (2024) Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis. Heliyon, 10 (3). e24975. ISSN 2405-8440

Pasinelli, P., Meyer, K., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (2 more authors) (2024) Editorial: The role of glial cells in neurodegeneration. Frontiers in Molecular Medicine, 3 (1337286). ISSN 2674-0095

Castelli, L.M., Lin, Y.-H., Sanchez-Martinez, A. et al. (19 more authors) (2023) A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science Translational Medicine, 15 (685). ISSN 1946-6234

Bauer, C.S., Webster, C.P., Shaw, A.C. et al. (12 more authors) (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience, 16. 1061559. ISSN 1662-5102

Aragón-González, A., Shaw, P.J. and Ferraiuolo, L. orcid.org/0000-0001-9118-5714 (2022) Blood–brain barrier disruption and its involvement in neurodevelopmental and neurodegenerative disorders. International Journal of Molecular Sciences, 23 (23). 15271. ISSN 1422-0067

Provenzano, F., Nyberg, S., Giunti, D. et al. (10 more authors) (2022) Micro-RNAs shuttled by extracellular vesicles secreted from mesenchymal stem cells dampen astrocyte pathological activation and support neuroprotection in in-vitro models of ALS. Cells, 11 (23). 3923. ISSN 2073-4409

Marchi, P.M. orcid.org/0000-0002-8893-3790, Marrone, L., Brasseur, L. et al. (19 more authors) (2022) C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons. Life Science Alliance, 5 (9). e202101276. ISSN 2575-1077

Han, Y., King, M., Tikhomirov, E. et al. (8 more authors) (2022) Towards 3D bioprinted spinal cord organoids. International Journal of Molecular Sciences, 23 (10). 5788. ISSN 1661-6596

Zhang, S., Cooper-Knock, J. orcid.org/0000-0002-0873-8689, Weimer, A.K. et al. (23 more authors) (2022) Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis. Neuron, 110 (6). pp. 992-1008. ISSN 0896-6273

Palminha, N.M., Dos Santos Souza, C. orcid.org/0000-0001-5314-6263, Griffin, J. orcid.org/0000-0003-3969-7637 et al. (3 more authors) (2022) Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease. Cellular and Molecular Life Sciences, 79 (3). 160. ISSN 1420-682X

Matuszyk, M.M., Garwood, C.J., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (3 more authors) (2022) Biological and methodological complexities of beta‐amyloid peptide; implications for Alzheimer’s disease research. Journal of Neurochemistry, 160 (4). pp. 434-453. ISSN 0022-3042

Perez-Nievas, B.G., Johnson, L., Beltran-Lobo, P. et al. (10 more authors) (2021) Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity. Journal of Neuroinflammation, 18 (1). 306.

Pasniceanu, I.-S., Atwal, M.S., Souza, C.D.S. et al. (2 more authors) (2021) Emerging mechanisms underpinning neurophysiological impairments in C9ORF72 repeat expansion-mediated amyotrophic lateral sclerosis/frontotemporal dementia. Frontiers in Cellular Neuroscience, 15. 784833. ISSN 1662-5102

Jiménez-Villegas, J., Ferraiuolo, L. orcid.org/0000-0001-9118-5714, Mead, R.J. orcid.org/0000-0002-3207-0068 et al. (3 more authors) (2021) NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS. Free Radical Biology and Medicine, 173. pp. 125-141. ISSN 0891-5849

Castelli, L.M., Cutillo, L., Souza, C.D.S. et al. (14 more authors) (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16 (1). 53.

Kok, J.R., Palminha, N.M., Dos Santos Souza, C. orcid.org/0000-0001-5314-6263 et al. (2 more authors) (2021) DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity. Cellular and Molecular Life Sciences, 78 (15). pp. 5707-5729. ISSN 1420-682X

Ciervo, Y., Gatto, N., Allen, C. et al. (4 more authors) (2021) Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS. Molecular Therapy — Methods & Clinical Development, 21. pp. 413-433. ISSN 2329-0501

Ferraiuolo, L. orcid.org/0000-0001-9118-5714 and Maragakis, N.J. (2021) Mini-review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets. Neuroscience Letters, 755. 135911. ISSN 0304-3940

Gatto, N., Dos Santos Souza, C., Shaw, A.C. et al. (12 more authors) (2021) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell, 20 (1). e13281. ISSN 1474-9718

Bell, S.M., Barnes, K., De Marco, M. orcid.org/0000-0002-9240-8067 et al. (5 more authors) (2021) Mitochondrial dysfunction in Alzheimer’s disease : a biomarker of the future? Biomedicines, 9 (1). 63.

Leah, T., Vazquez-Villaseñor, I., Ferraiuolo, L. et al. (2 more authors) (2021) A Parkinson’s disease-relevant mitochondrial and neuronal morphology high-throughput screening assay in LUHMES cells. Bio-protocol, 11 (1). ISSN 2331-8325

Schwartzentruber, A., Boschian, C., Lopes, F.M. et al. (6 more authors) (2020) Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons. Scientific Reports, 10 (1). 15485. ISSN 2045-2322

Myszczynska, M.A. orcid.org/0000-0003-0067-8500, Ojamies, P.N., Lacoste, A.M.B. et al. (6 more authors) (2020) Applications of machine learning to diagnosis and treatment of neurodegenerative diseases. Nature Reviews Neurology, 16. pp. 440-456. ISSN 1759-4758

Bell, S.M., De Marco, M., Barnes, K. et al. (5 more authors) (2020) Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of alzheimer’s disease. Journal of Personalized Medicine, 10 (2). 32. ISSN 2075-4426

Carling, P.J., Mortiboys, H. orcid.org/0000-0001-6439-0579, Green, C. et al. (21 more authors) (2020) Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease. Progress in Neurobiology, 187. 101772. ISSN 0301-0082

Allen, S.P., Hall, B., Woof, R. et al. (16 more authors) (2019) C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis. Brain. 302. pp. 1-20. ISSN 0006-8950

Stopford, M., Allen, S. and Ferraiuolo, L. orcid.org/0000-0001-9118-5714 (2019) A high-throughput and pathophysiologically relevant astrocyte-motor neuron co-culture assay for amyotrophic lateral sclerosis therapeutic discovery. Bio-protocol, 9 (17). ISSN 2331-8325

Allen, S., Hall, B., Castelli, L. et al. (19 more authors) (2019) Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis. Brain, 142 (3). pp. 586-605. ISSN 0006-8950

Varcianna, A.E., Myszczynska, M.A., Castelli, L.M. et al. (9 more authors) (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine, 40. pp. 626-635. ISSN 2352-3964

Iannitti, T., Scarrott, J., Likhite, S. et al. (12 more authors) (2018) Translating SOD1 gene silencing towards the clinic: A highly efficacious, off-target free and biomarker-supported strategy for familial ALS. Molecular Therapy : Nucleic Acids, 12. pp. 75-88. ISSN 2162-2531

Ferraiuolo, L. orcid.org/0000-0001-9118-5714 and Shaw, P. orcid.org/0000-0002-8925-2567 (2018) Lost in translation: microRNAs mediate pathological cross-talk between motor neurons and astrocytes. Brain, 141 (9). pp. 2534-2536. ISSN 0006-8950

Bell, S.M., Barnes, K., Clemmens, H. et al. (8 more authors) (2018) Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with either Sporadic or Familial Alzheimer's Disease. Journal of Molecular Biology. ISSN 0022-2836

Castelli, L.M., Lin, Y.H., Ferraiuolo, L. et al. (6 more authors) (2018) SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection. Therapeutic Targets for Neurological Diseases, 4. e1619. ISSN 2376-0478

Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Castelli, L.M., Ferraiuolo, L. et al. (23 more authors) (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. 16063 (2017).

Rinaldi, F., Motti, D., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (1 more author) (2017) High Content Analysis in Amyotrophic Lateral Sclerosis. Molecular and Cellular Neuroscience, 80. pp. 180-191. ISSN 1044-7431

Frakes, A.E., Braun, L., Ferraiuolo, L. orcid.org/0000-0001-9118-5714 et al. (2 more authors) (2017) Additive amelioration of ALS by co-targeting independent pathogenic mechanisms. Annals of Clinical and Translational Neurology, 4 (2). pp. 76-86.

Glajch, K.E., Ferraiuolo, L. orcid.org/0000-0001-9118-5714, Mueller, K.A. et al. (5 more authors) (2016) MicroNeurotrophins Improve Survival in Motor Neuron-Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One, 11 (10). e0164103. ISSN 1932-6203

Webster, C.P., Smith, E.F., Bauer, C.S. et al. (12 more authors) (2016) The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy. EMBO Journal, 35 (15). pp. 1656-1676.

Song, S., Miranda, C. J., Braun, L. et al. (9 more authors) (2016) Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis. Nature Medicine, 22. pp. 397-403. ISSN 1078-8956

Myszczynska, M. and Ferraiuolo, L. orcid.org/0000-0001-9118-5714 (2016) New In Vitro Models to Study Amyotrophic Lateral Sclerosis. Brain Pathology, 26 (2). pp. 258-265. ISSN 1015-6305

Ferraiuolo, L. orcid.org/0000-0001-9118-5714, Meyer, K., Sherwood, T. et al. (12 more authors) (2016) Oligodendrocytes contribute to motor neuron death in ALS via SOD1 dependent mechanism. Proceedings of the National Academy of Sciences, 113 (42). E6496-E6505. ISSN 1091-6490

Sun, S., Sun, Y., Ling, S.C. et al. (11 more authors) (2015) Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490, 112 (50). E6993 - E7002.

Baker, D.J., Blackburn, D.J., Keatinge, M. et al. (6 more authors) (2015) Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience, 9. 410. ISSN 1662-5102

Marino, M., Papa, S., Crippa, V. et al. (11 more authors) (2015) Differences in protein quality control correlate with phenotype variability in 2 mouse models of familial amyotrophic lateral sclerosis. Neurobiology of Aging, 36 (1). 492 - 504. ISSN 0197-4580

Meyer, K., Ferraiuolo, L., Schmelzer, L. et al. (11 more authors) (2014) Improving single injection CSF delivery of AAV9-mediated gene therapy for SMA: A dose-response study in mice and nonhuman primates. Molecular Therapy, 23 (3). 477 -487. ISSN 1525-0016

Kirby, J., Ning, K., Ferraiuolo, L. et al. (10 more authors) (2011) Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis. Brain, 134 (2). pp. 506-517. ISSN 0006-8950

Cox, L.E., Ferraiuolo, L., Goodall, E.F. et al. (13 more authors) (2010) Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). Plos One, 5 (3). Art no.e9872. ISSN 1932-6203

Book Section

Allen, C., Shaw, P.J. and Ferraiuolo, L. orcid.org/0000-0001-9118-5714 (2017) Can astrocytes be a target for precision medicine? In: El-Khamisy, S., (ed.) Personalised Medicine. Advances in Experimental Medicine and Biology (1007). Springer . ISBN 978-3-319-60731-3

Proceedings Paper

Bell, S., De Marco, M., Barnes, K. et al. (5 more authors) (2020) Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer's disease? In: Neurology. UNSPECIFIED. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology .

Allen, S.P., Hall, B., Castelli, L. orcid.org/0000-0003-3620-4219 et al. (11 more authors) (2018) Inosine reverses motor neuron toxicity observed in amyotrophic lateral sclerosis patient astrocytes with an adenosine deaminase deficiency. In: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 20th European Bioenergetics Conference, 25-30 Aug 2018, Budapest, Hungary. Elsevier BV , e23-e23.

Iannitti, T., Scarrot, J.M., Coldicott, I.R.P. et al. (4 more authors) (2016) Gene Therapy for Familial ALS Using AAV9 Mediated Silencing of Mutant SOD1. In: Human Gene Therapy. British Society for Gene and Cell Therapy Annual Conference, 15th April 2016, University College London Institute of Child Health. Mary Ann Liebert Inc , A12-A12.