Items where authors include "Castelli, L.M."

Article

Webster, C.P. orcid.org/0000-0003-4197-2036, Hall, B. orcid.org/0009-0008-4274-9796, Crossley, O.M. et al. (14 more authors) (2025) RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD. Life Science Alliance, 8 (2). e202402757. ISSN 2575-1077

Burrows, D.J. orcid.org/0000-0002-5833-9379, McGown, A., Abduljabbar, O. et al. (4 more authors) (2024) RAN translation of C9orf72-related dipeptide repeat proteins in zebrafish recapitulates hallmarks of amyotrophic lateral sclerosis and identifies hypothermia as a therapeutic strategy. Annals of Neurology, 96 (6). pp. 1058-1069. ISSN 0364-5134

Mihaylov, S.R. orcid.org/0000-0001-6872-0635, Castelli, L.M., Lin, Y.-H. orcid.org/0000-0003-1576-4655 et al. (13 more authors) (2023) The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function. Nature Communications, 14. 5496.

Allen, S.P. orcid.org/0000-0003-4418-7375, Al Sultan, A., Kabucho Kibirige, E. et al. (13 more authors) (2023) A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations. Frontiers in Aging Neuroscience, 15. 1151848. ISSN 1663-4365

Castelli, L.M., Lin, Y.-H., Sanchez-Martinez, A. et al. (19 more authors) (2023) A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. Science Translational Medicine, 15 (685). ISSN 1946-6234

Bauer, C.S., Webster, C.P., Shaw, A.C. et al. (12 more authors) (2022) Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation. Frontiers in Cellular Neuroscience, 16. 1061559. ISSN 1662-5102

Castelli, L.M. orcid.org/0000-0003-3620-4219, Benson, B.C., Huang, W.-P. et al. (2 more authors) (2022) RNA helicases in microsatellite repeat expansion disorders and neurodegeneration. Frontiers in Genetics, 13. 886563. ISSN 1664-8021

Castelli, L.M., Cutillo, L., Souza, C.D.S. et al. (14 more authors) (2021) SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export : genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Molecular Neurodegeneration, 16 (1). 53.

Nwokoye, E.C., AlNaseem, E., Crawford, R.A. et al. (4 more authors) (2021) Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes. Scientific Reports, 11 (1). 13467.

Castelli, L.M., Huang, W.-P., Lin, Y.-H. et al. (2 more authors) (2021) Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders. Biochemical Society Transactions, 49 (2). pp. 775-792. ISSN 0300-5127

Gatto, N., Dos Santos Souza, C., Shaw, A.C. et al. (12 more authors) (2021) Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease. Aging Cell, 20 (1). e13281. ISSN 1474-9718

Varcianna, A.E., Myszczynska, M.A., Castelli, L.M. et al. (9 more authors) (2019) Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS. EBioMedicine, 40. pp. 626-635. ISSN 2352-3964

Shaw, M.P., Higginbottom, A. orcid.org/0000-0002-3246-6695, McGown, A. et al. (5 more authors) (2018) Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features. Acta Neuropathologica Communications, 6 (1). 125. ISSN 2051-5960

Morgan, S.V., Garwood, C.J., Jennings, L. et al. (10 more authors) (2018) Proteomic and cellular localisation studies suggest non-tight junction cytoplasmic and nuclear roles for occludin in astrocytes. European Journal of Neuroscience, 47 (12). pp. 1444-1456. ISSN 0953-816X

Talavera, D., Kershaw, C.J., Costello, J.L. et al. (7 more authors) (2018) Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions. Scientific Reports, 8 (1). 7949. ISSN 2045-2322

Castelli, L.M., Lin, Y.H., Ferraiuolo, L. et al. (6 more authors) (2018) SRSF1-dependent nuclear export of C9ORF72 repeat-transcripts: targeting toxic gain-of-functions induced by protein sequestration as a selective therapeutic strategy for neuroprotection. Therapeutic Targets for Neurological Diseases, 4. e1619. ISSN 2376-0478

Costello, J.L., Kershaw, C.J., Castelli, L.M. et al. (7 more authors) (2017) Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biology , 18. 201. ISSN 1474-760X

Egbe, N.E., Dornelles, T.O., Paget, C.M. et al. (2 more authors) (2017) Farnesol inhibits translation to limit growth and filamentation in C. albicans and S. cerevisiae. Microbial Cell, 4 (9). pp. 294-304.

Hautbergue, G.M. orcid.org/0000-0002-1621-261X, Castelli, L.M., Ferraiuolo, L. et al. (23 more authors) (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. Nature Communications, 8. 16063 (201.

Kershaw, C.J., Costello, J.L., Talavera, D. et al. (7 more authors) (2015) Integrated multi-omics analyses reveal the pleiotropic nature of the control of gene expression by Puf3p. Scientific Reports, 5. ARTN 15518. ISSN 2045-2322

Castelli, L.M., Talavera, D., Kershaw, C.J. et al. (8 more authors) (2015) The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation. PLoS Genetics, 11 (5). e1005233. ISSN 1553-7390

Kershaw, C.J., Costello, J.L., Castelli, L.M. et al. (7 more authors) (2015) The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response. PLoS Genetics, 11 (1). e1004903. ISSN 1553-7390

Costello, J., Castelli, L.M., Rowe, W. et al. (8 more authors) (2015) Global mRNA selection mechanisms for translation initiation. Genome Biology, 16. 10. ISSN 1474-760X

Rowe, W., Kershaw, C.J., Castelli, L.M. et al. (6 more authors) (2014) Puf3p induces translational repression of genes linked to oxidative stress. Nucleic Acids Research, 42 (2). pp. 1026-1041. ISSN 0305-1048

Castelli, L.M., Lui, J., Campbell, S.G. et al. (8 more authors) (2011) Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated. Molecular Biology of the Cell , 22 (18). pp. 3379-3393. ISSN 1059-1524

Cridge, A.G., Castelli, L.M., Smirnova, J.B. et al. (7 more authors) (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Research, 38 (22). pp. 8039-8050. ISSN 0305-1048

Hoyle, N.P., Castelli, L.M., Campbell, S.G. et al. (2 more authors) (2007) Stress-dependent relocalization of translationally primed mRNPs to cytoplasmic granules that are kinetically and spatially distinct from P-bodies. Journal of Cell Biology, 179 (1). pp. 65-74. ISSN 0021-9525