Items where authors include "Brockwell, DJ"

Article

Aufderhorst-Roberts, A, Cussons, S, Brockwell, DJ orcid.org/0000-0002-0802-5937 et al. (1 more author) (2023) Diversity of viscoelastic properties of an engineered muscle-inspired protein hydrogel. Soft Matter, 19 (17). pp. 3167-3178. ISSN 1744-683X

Brown, CP orcid.org/0000-0002-6551-3953, Hughes, MDG orcid.org/0000-0001-5838-7939, Mahmoudi, N orcid.org/0000-0003-4936-6911 et al. (5 more authors) (2023) Structural and mechanical properties of folded protein hydrogels with embedded microbubbles. Biomaterials Science, 11 (8). pp. 2726-2737. ISSN 2047-4830

Bruce, AJE, Paci, E and Brockwell, DJ orcid.org/0000-0002-0802-5937 (2023) Collagen-like motifs of SasG: a novel fold for protein mechanical strength. Journal of Molecular Biology, 435 (6). 167980. ISSN 0022-2836

Ulamec, SM, Maya-Martinez, R, Byrd, EJ orcid.org/0000-0002-9876-1400 et al. (9 more authors) (2022) Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein. Nature Communications, 13. 4986. ISSN 2041-1723

Hughes, MDG orcid.org/0000-0001-5838-7939, Cussons, S orcid.org/0000-0002-9318-3859, Mahmoudi, N orcid.org/0000-0003-4936-6911 et al. (2 more authors) (2022) Tuning Protein Hydrogel Mechanics through Modulation of Nanoscale Unfolding and Entanglement in Postgelation Relaxation. ACS Nano, 16 (7). pp. 10667-10678. ISSN 1936-0851

Schiffrin, B, Machin, JM, Karamanos, TK orcid.org/0000-0003-2297-540X et al. (4 more authors) (2022) Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding. Communications Biology, 5. 560. ISSN 2399-3642

Guthertz, N orcid.org/0000-0001-7247-1176, van der Kant, R orcid.org/0000-0003-3639-9749, Martinez, RM orcid.org/0000-0002-7371-8051 et al. (7 more authors) (2022) The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proceedings of the National Academy of Sciences (PNAS), 119 (22). e2200468119. ISSN 0027-8424

Mclure, RJ, Radford, SE orcid.org/0000-0002-3079-8039 and Brockwell, DJ orcid.org/0000-0002-0802-5937 (2022) High-throughput directed evolution: a golden era for protein science. Trends in Chemistry, 4 (5). pp. 378-391. ISSN 2589-5974

Hughes, MDG orcid.org/0000-0001-5838-7939, Hanson, BS orcid.org/0000-0002-6079-4506, Cussons, S et al. (3 more authors) (2021) Control of Nanoscale In Situ Protein Unfolding Defines Network Architecture and Mechanics of Protein Hydrogels. ACS Nano, 15 (7). acsnano.1c00353. pp. 11296-11308. ISSN 1936-0851

White, P orcid.org/0000-0001-7536-4552, Haysom, SF orcid.org/0000-0002-8769-090X, Iadanza, MG orcid.org/0000-0001-6152-1844 et al. (12 more authors) (2021) The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding. Nature Communications, 12. 4174. ISSN 2041-1723

Vorobieva, AA, White, P orcid.org/0000-0001-7536-4552, Liang, B et al. (16 more authors) (2021) De novo design of transmembrane β-barrels. Science, 371 (6531). eabc8182. ISSN 0036-8075

Iadanza, MG, Schiffrin, B, White, P orcid.org/0000-0001-7536-4552 et al. (9 more authors) (2020) Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs. Communications Biology, 3. 766. ISSN 2399-3642

Ulamec, SM orcid.org/0000-0002-9415-753X, Brockwell, DJ orcid.org/0000-0002-0802-5937 and Radford, SE orcid.org/0000-0002-3079-8039 (2020) Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins. Frontiers in Neuroscience, 14 (611285). ISSN 1662-4548

Aufderhorst-Roberts, A orcid.org/0000-0003-3559-9423, Hughes, M, Hare, A et al. (4 more authors) (2020) Reaction Rate Governs the Viscoelasticity and Nanostructure of Folded Protein Hydrogels. Biomacromolecules, 21 (10). acs.biomac.0c01044. pp. 4253-4260. ISSN 1525-7797

Schiffrin, B, Radford, SE orcid.org/0000-0002-3079-8039, Brockwell, DJ orcid.org/0000-0002-0802-5937 et al. (1 more author) (2020) PyXlinkViewer: A flexible tool for visualization of protein chemical crosslinking data within the PyMOL molecular graphics system. Protein Science, 29 (8). pp. 1851-1857. ISSN 0961-8368

Hughes, MDG orcid.org/0000-0001-5838-7939, Cussons, S orcid.org/0000-0002-9318-3859, Mahmoudi, N orcid.org/0000-0003-4936-6911 et al. (2 more authors) (2020) Single molecule protein stabilisation translates to macromolecular mechanics of a protein network. Soft Matter. ISSN 1744-683X

Horne, JE, Brockwell, DJ orcid.org/0000-0002-0802-5937 and Radford, SE orcid.org/0000-0002-3079-8039 (2020) Role of the lipid bilayer in outer membrane protein folding in Gram negative bacteria. Journal of Biological Chemistry. jbc.REV120.011473. ISSN 0021-9258

Calabrese, AN orcid.org/0000-0003-2437-7761, Schiffrin, B orcid.org/0000-0002-1670-7356, Watson, M orcid.org/0000-0003-2166-6840 et al. (11 more authors) (2020) Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Nature Communications, 11. 2155. ISSN 2041-1723

Willis, LF orcid.org/0000-0001-6616-3716, Kumar, A, Jain, T et al. (6 more authors) (2020) The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies. Engineering Reports, 2 (5). e12147. ISSN 2577-8196

Ebo, JS orcid.org/0000-0002-5684-4355, Saunders, JC, Devine, PWA et al. (12 more authors) (2020) An in vivo platform to select and evolve aggregation-resistant proteins. Nature Communications, 11. 1816. ISSN 2041-1723

Doherty, CPA orcid.org/0000-0001-5685-4716, Ulamec, SM orcid.org/0000-0002-9415-753X, Maya-Martinez, R orcid.org/0000-0002-7371-8051 et al. (6 more authors) (2020) A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function. Nature Structural & Molecular Biology, 27. pp. 249-259. ISSN 1545-9993

Ebo, JS, Guthertz, N, Radford, SE orcid.org/0000-0002-3079-8039 et al. (1 more author) (2020) Using Protein Engineering to Understand and Modulate Aggregation. Current Opinion in Structural Biology, 60. pp. 157-166. ISSN 0959-440X

Humes, JR orcid.org/0000-0002-1407-7880, Schiffrin, B, Calabrese, AN et al. (4 more authors) (2019) The Role of SurA PPIase Domains in Preventing Aggregation of the Outer Membrane Proteins tOmpA and OmpT. Journal of Molecular Biology, 431 (6). pp. 1267-1283. ISSN 0022-2836

Horne, JE, Walko, M, Calabrese, AN et al. (5 more authors) (2018) Rapid Mapping of Protein Interactions Using Tag‐Transfer Photocrosslinkers. Angewandte Chemie, 130 (51). pp. 16930-16934. ISSN 0044-8249

Doherty, CPA orcid.org/0000-0001-5685-4716, Young, LM, Karamanos, TK et al. (4 more authors) (2018) A peptide‐display protein scaffold to facilitate single molecule force studies of aggregation‐prone peptides. Protein Science, 27 (7). pp. 1205-1217. ISSN 0961-8368

Willis, LF orcid.org/0000-0001-6616-3716, Kumar, A, Dobson, J et al. (6 more authors) (2018) Using extensional flow to reveal diverse aggregation landscapes for three IgG1 molecules. Biotechnology and Bioengineering, 115 (5). pp. 1216-1225. ISSN 0006-3592

Kumar, A, Gopalswamy, M, Wolf, A et al. (3 more authors) (2018) Phosphorylation-induced unfolding regulates p19(INK4d) during the human cell cycle. Proceedings of the National Academy of Sciences of the United States of America, 115 (13). pp. 3344-3349. ISSN 0027-8424

Schiffrin, B, Brockwell, DJ orcid.org/0000-0002-0802-5937 and Radford, SE orcid.org/0000-0002-3079-8039 (2017) Outer membrane protein folding from an energy landscape perspective. BMC Biology, 15 (1). 123. ISSN 1741-7007

Schiffrin, R, Calabrese, AN, Higgins, AJ et al. (5 more authors) (2017) Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding. Journal of Molecular Biology, 429. pp. 3776-3792. ISSN 0022-2836

Dobson, J, Kumar, A orcid.org/0000-0001-8391-6812, Willis, LF orcid.org/0000-0001-6616-3716 et al. (8 more authors) (2017) Inducing protein aggregation by extensional flow. Proceedings of the National Academy of Sciences, 114 (18). pp. 4673-4678. ISSN 0027-8424

Hickman, SJ, Cooper, REM, Bellucci, L et al. (2 more authors) (2017) Gating of TonB-dependent transporters by substrate-specific forced remodelling. Nature Communications, 8. 14804. ISSN 2041-1723

Alves da Silva, M, Lenton, S, Hughes, M et al. (2 more authors) (2017) Assessing the potential of folded globular polyproteins as hydrogel building blocks. Biomacromolecules, 18 (2). pp. 636-646. ISSN 1525-7797

Iadanza, MG, Higgins, AJ, Schiffrin, R et al. (5 more authors) (2016) Lateral opening in the intact β-barrel assembly machinery captured by cryo-EM. Nature Communications, 7. 12865.

Schiffrin, B, Calabrese, AN, Devine, PWA et al. (4 more authors) (2016) Skp is a multivalent chaperone of outer membrane proteins. Nature Structural and Molecular Biology, 23 (9). pp. 786-793. ISSN 1545-9993

Tych, KM, Batchelor, M orcid.org/0000-0001-6338-5698, Hoffmann, T et al. (5 more authors) (2016) Differential effects of hydrophobic core packing residues for thermodynamic and mechanical stability of a hyperthermophilic protein. Langmuir : the ACS journal of surfaces and colloids, 32 (29). pp. 7392-7402. ISSN 0743-7463

Tych, KM, Batchelor, M, Hoffmann, T et al. (4 more authors) (2016) Tuning protein mechanics through an ionic cluster graft from an extremophilic protein. Soft Matter, 12 (10). pp. 2688-2699. ISSN 1744-683X

Saunders, JC, Young, LM, Mahood, RA et al. (7 more authors) (2016) An in vivo platform for identifying inhibitors of protein aggregation. Nature Chemical Biology, 12 (2). pp. 94-101. ISSN 1552-4450

Hoffmann, T, Tych, KM, Crosskey, T et al. (3 more authors) (2015) Rapid and Robust Polyprotein Production Facilitates Single-Molecule Mechanical Characterization of β-Barrel Assembly Machinery Polypeptide Transport Associated Domains. ACS Nano, 9 (9). pp. 8811-8821. ISSN 1936-0851

Gruszka, DT, Whelan, F, Farrance, OE et al. (9 more authors) (2015) Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein. Nature Communications, 6. 7271. 7271 - ?.

Tych, KM, Hoffmann, T, Batchelor, M et al. (6 more authors) (2015) Life in extreme environments: Single molecule force spectroscopy as a tool to explore proteins from extremophilic organisms. Biochemical Society Transactions, 43 (2). 179 - 185. ISSN 0300-5127

Farrance, OE, Paci, E orcid.org/0000-0002-4891-2768, Radford, SE orcid.org/0000-0002-3079-8039 et al. (1 more author) (2015) Extraction of Accurate Biomolecular Parameters from Single-Molecule Force Spectroscopy Experiments. ACS Nano, 9 (2). pp. 1315-1324. ISSN 1936-0851

Chen, Y, Radford, SE and Brockwell, DJ (2015) Force-induced remodelling of proteins and their complexes. Current Opinion in Structural Biology, 30. 89 - 99. ISSN 0959-440X

Tych, KM, Hughes, ML, Bourke, J et al. (4 more authors) (2015) Optimizing the calculation of energy landscape parameters from single-molecule protein unfolding experiments. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 91 (1). 12710 - 12719 (10). ISSN 1539-3755

McMorran, LM, Brockwell, DJ and Radford, SE (2014) Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: what have we learned to date? Archives of Biochemistry and Biophysics, 564. 265 - 280. ISSN 0003-9861

McMorran, LM, Bartlett, AL, Huysmans, GHM et al. (2 more authors) (2013) Dissecting the effects of periplasmic chaperones on the in vitro folding of the outer membrane protein PagP. Journal of Molecular Biology, 425 (17). 3178 - 3191. ISSN 0022-2836

Hoffmann, T, Tych, KM, Hughes, ML et al. (2 more authors) (2013) Towards design principles for determining the mechanical stability of proteins. Physical Chemistry Chemical Physics, 15 (38). 15767 - 15780. ISSN 1463-9076