Rodriguez Barzano, A, Lord, R, Basri, AM et al. (3 more authors) (2015) Synthesis and anticancer activity evaluation of eta(5)-C-5(CH3)(4)R ruthenium complexes bearing chelating diphosphine ligands. Dalton Transactions, 44 (7). pp. 3265-3270. ISSN 1477-9226
Abstract
The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
| Funding Information: | Funder Grant number Innovate UKfka Technology Strategy Board (TSB) BD368B Innovate UKfka Technology Strategy Board (TSB) EP/K504154/1 |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 05 May 2016 12:46 |
| Last Modified: | 05 May 2016 12:46 |
| Published Version: | https://dx.doi.org/10.1039/c4dt02748e |
| Status: | Published |
| Publisher: | Royal Society of Chemistry |
| Identification Number: | 10.1039/c4dt02748e |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96011 |
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