Bagheri-Yarmand, R, Sinha, KM, Gururaj, AE et al. (8 more authors) (2015) A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. Journal of Biological Chemistry, 290 (18). 11749 - 11761. ISSN 0021-9258
Abstract
Background: Activating mutations of the receptor tyrosine kinase RET are associated with oncogenic function in medullary thyroid cancer. Results: RET is a dual specificity kinase phosphorylates ATF4, and inhibits expression of the ATF4 target proapoptotic genes. Conclusion: RET prevents apoptosis through inhibition of ATF4 activity. Significance Simultaneous targeting of RET and ATF4 may provide clinical benefit in cancers with RET abnormalities.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Keywords: | Apoptosis; Thyroid; Transcription Regulation; Transcription Repressor; Tyrosine-Protein Kinase (Tyrosine Kinase); Ubiquitylation (Ubiquitination) |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 08 Oct 2015 13:43 |
| Last Modified: | 17 Nov 2015 06:48 |
| Published Version: | http://dx.doi.org/10.1074/jbc.M114.619833 |
| Status: | Published |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Identification Number: | 10.1074/jbc.M114.619833 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86991 |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)