β-D-Arabinofuranose-configured cyclitol aziridines as selective, brain-penetrant covalent GBA2 inhibitors

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Item Type:	Article
Authors/Creators:	Lammers, Rob F. Su, Qin Mazo, Laura Offen, Wendy A. https://orcid.org/0000-0002-2758-4531 Ottenhoff, Roelof Bulterman, Mats J. van der Lienden, Martijn Ferraz, Maria J. Küllmer, Florian Ilhan, Zahid van den Elst, Hans van der Made, Ingeborg van Roomen, Cindy P.A.A. de Jongh, Anne van den Nieuwendijk, Adrianus M.C.H. Boot, Rolf G. Zelcer, Noam Davies, Gideon J. https://orcid.org/0000-0002-7343-776X Rovira, Carme Overkleeft, Herman S. Aerts, Johannes M.F.G. Artola, Marta
Copyright, Publisher and Additional Information:	© 2026 The Authors.
Dates:	Accepted: 16 September 2026 Published (online): 29 September 2026 Published: 14 October 2026
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Chemistry (York)
Funding Information:	Funder Grant number EUROPEAN COMMISSION 951231 BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL) BB/T017805/1 THE ROYAL SOCIETY RSRP\R\210004
Date Deposited:	16 Oct 2026 10:05
Last Modified:	07 Nov 2026 00:31
Published Version:	https://doi.org/10.1021/jacs.6c09754
Status:	Published
Refereed:	Yes
Identification Number:	10.1021/jacs.6c09754
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:246859

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Description: β‑D‑Arabinofuranose-configured Cyclitol Aziridines as Selective, Brain-penetrant Covalent GBA2 Inhibitors

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