Multiple‐dose results from an ongoing phase 1 study of mivelsiran, an investigational RNA interference therapeutic targeting amyloid‐beta precursor protein for Alzheimer’s disease

Cohen, S., Ducharme, S., Brosch, J.R. et al. (9 more authors) (2025) Multiple‐dose results from an ongoing phase 1 study of mivelsiran, an investigational RNA interference therapeutic targeting amyloid‐beta precursor protein for Alzheimer’s disease. In: Alzheimer's & Dementia. Alzheimer's Association International Conference 2025 (AAIC 2025), 27-31 Jul 2025, Toronto, Canada. Wiley. Article no: e097989. ISSN: 1552-5260. EISSN: 1552-5279.

Metadata

Item Type: Proceedings Paper
Authors/Creators:
  • Cohen, S.
  • Ducharme, S.
  • Brosch, J.R.
  • Vijverberg, E.G.B.
  • Blackburn, D.J.
  • McDade, E.
  • Sostelly, A.
  • Chaudhari, S.
  • Farrugia, L.
  • Deering, R.W.
  • Shirvan, J.
  • Mummery, C.J.
Copyright, Publisher and Additional Information:

© 2025 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Biomedical and Clinical Sciences; Neurosciences; Clinical Sciences; Clinical Trials and Supportive Activities; Brain Disorders; Neurosciences; Acquired Cognitive Impairment; Dementia; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Clinical Research; Alzheimer's Disease; Aging; Neurodegenerative; Pharmaceuticals; Neurological; 3 Good Health and Well Being; Humans; Male; Alzheimer Disease; Female; Middle Aged; Drug Development; Aged; Double-Blind Method; Amyloid beta-Protein Precursor; Treatment Outcome; Dose-Response Relationship, Drug
Dates:
  • Published (online): 25 December 2025
  • Published: December 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Date Deposited: 14 Jan 2026 09:15
Last Modified: 14 Jan 2026 14:07
Status: Published
Publisher: Wiley
Refereed: Yes
Identification Number: 10.1002/alz70859_097989
Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
Open Archives Initiative ID (OAI ID):

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