Moretti, H., Cioccoloni, G. orcid.org/0000-0003-0102-9182 and Perucha, E. (Accepted: 2025) Immunometabolism in cancer: a systemic perspective. Frontiers in Immunology, 16. ISSN: 1664-3224 (In Press)
Abstract
Cancer incidence is increasing, becoming a significant public health concern. Cancer arises from the uncontrolled division of cells that cannot be restrained by the anti-tumour response mounted by the immune system. Both tumour and immune cells require high levels of energy in the form of ATP and synthesis of macromolecules to support differentiation and proliferation. To support these metabolic demands, adaptations at the cell, tissue and systemic level are required. Here, we take a systemic perspective to summarise the energetic needs of the anti-tumour response and how metabolic overload and obesity affects these processes. We describe how immunotherapies that aim to reverse immune cell exhaustion have unexpected effects depending on the metabolic background of the patient and finally we propose the use of this knowledge to advance current cancer prevention and treatment strategies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Cancer, systemic immunometabolism, Immunotherapy, Obesity, T cells |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Date Deposited: | 03 Oct 2025 10:58 |
Last Modified: | 03 Oct 2025 10:58 |
Status: | In Press |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fimmu.2025.1656776 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:232468 |