Developing the future of clinical radiopharmacy: Optimising on-chip gallium-68 radiolabelling for pet imaging

Positron emission tomography (PET) imaging is a growing area with major interest in radiometal labelling and dose-on-demand supply. However, current production methods do not match effectively with these requirements. Microreactor technology is a promising candidate as a future standard radiosynthesis tool. The fluid transport is commonly achieved using syringe pump, but it cannot handle different processes alongside. Herein, we describe an alternative fluid transport mechanism for gallium-68 radiolabelling via peristaltic pump. The optimisation of this reaction yielded a two-fold decrease in the required quantity of chelator after 4 min of reaction at room temperature.