Truhlar, Michael, Katebifar, Sobhan, Rosenberg, Bradley et al. (2 more authors) (2025) Multi-modal comparison of murine and human incisal dentin-enamel junctions. Acta Biochimica Polonica. 14642. ISSN: 1734-154X
Abstract
Human and mouse incisors are both primarily composed of dentin and enamel, which meet at an interface called the dentin-enamel junction (DEJ). However, incisors in the two species have very different growth patterns, structures, and loading requirements. Since the DEJ is responsible for minimizing cracking at this at-risk interface between mechanically dissimilar dentin and enamel, its structure is expected to be significantly different between humans and mice. Here, structural and compositional gradients across human and murine incisors DEJs were measured via microcomputed tomography and Raman spectroscopy. Density gradients across the DEJ were significantly larger in humans compared to murine teeth, likely due to the larger size of the mantle dentin. Multiple gradients in mineral content and crystallinity were found at the murine DEJ, while the human DEJ only exhibited gradients in mineral content. Models predicting the modulus across the DEJ according to compositional results show that mineral crystallinity is critical in regulating gradients in tissue stiffness across the murine DEJ. Together, these results show the multiple ways in which the DEJ can adapt to variations in the loading environment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Publisher Copyright: Copyright © 2025 Truhlar, Katebifar, Rosenberg, Kroger and Deymier. |
Keywords: | dental Morphology,dentin,enamel,mechanical properties,micro-computed tomography |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 12 Sep 2025 13:30 |
Last Modified: | 20 Sep 2025 02:28 |
Published Version: | https://doi.org/10.3389/abp.2025.14642 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3389/abp.2025.14642 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:231530 |