NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction

Wong, F.C.K., Zhang, M., Thomson, E. orcid.org/0000-0002-5596-3563 et al. (9 more authors) (2025) NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction. The EMBO Journal. pp. 1-38. ISSN: 0261-4189

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Item Type: Article
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© 2025 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

Keywords: SOX2; NANOG; Embryo; Pluripotency; Post Implantation
Dates:
  • Submitted: 21 March 2025
  • Accepted: 23 July 2025
  • Published (online): 18 August 2025
  • Published: 18 August 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 28 Aug 2025 14:47
Last Modified: 28 Aug 2025 14:47
Status: Published online
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s44318-025-00527-9
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