Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation

Abstract

Deep brain stimulation (DBS) studies in Parkinson's Disease (PD) targeting the subthalamic nucleus (STN) have characterized its spectral properties across cognitive processes. In emotional evaluation tasks, specific alpha frequency (8–12 Hz) event-related de-synchronization (ERD) (reduced power) has been demonstrated. The time-locked stimulation of STN relative to stimuli onset has shown subjective positive valence shifts with 10 Hz but not with 130 Hz. However, neurophysiological effects of stimulation on power modulation have not been investigated. We aim to investigate effects of acute stimulation of the right STN on concurrent power modulation in the contralateral STN and frontal scalp EEG. From our previous study, we had a strong a priori hypothesis that negative imagery without stimulation would be associated with alpha ERD; negative imagery with 130 Hz stimulation would be also associated with alpha ERD given the lack of its effect on subjective valence ratings; negative imagery with 10 Hz stimulation was to be associated with enhanced alpha power given the shift in behavioral valence ratings.

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Item Type:	Article
Authors/Creators:	Muhammad, N. Sonkusare, S. Ding, Q. Wang, L. Mandali, A. https://orcid.org/0000-0001-9206-7613 Zhao, Y.J. Sun, B. Li, D. Voon, V.
Copyright, Publisher and Additional Information:	© 2023 Muhammad, Sonkusare, Ding, Wang, Mandali, Zhao, Sun, Li and Voon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
Keywords:	deep brain stimulation (DBS); acute stimulation; alpha frequency; emotion; event related (de)/synchronization
Dates:	Submitted: 7 March 2023 Accepted: 23 May 2023 Published (online): 27 July 2023 Published: 27 July 2023
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	09 May 2025 11:01
Last Modified:	09 May 2025 11:01
Status:	Published
Publisher:	Frontiers Media SA
Refereed:	Yes
Identification Number:	10.3389/fnhum.2023.1181635
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:226270

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Time-locked acute alpha-frequency stimulation of subthalamic nuclei during the evaluation of emotional stimuli and its effect on power modulation

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