Guo, J. orcid.org/0000-0002-4818-1520 and Anthony, K. (2023) A systematic literature review and meta-analysis of the effectiveness of vitamin D supplementation for patients with Duchenne muscular dystrophy. Neuromuscular Disorders, 33 (11). pp. 835-844. ISSN 0960-8966
Abstract
We conducted a systematic literature review and meta-analysis on the effectiveness of vitamin D supplementation in maintaining or restoring vitamin D levels in Duchenne muscular dystrophy. Due to a lack of randomised controlled trials, cross-sectional and retrospective and prospective cohort studies were taken as the best available evidence. Inclusion criteria included reporting mean serum vitamin D levels in a supplement-taking group. After screening 102 records; 13 were included in a narrative synthesis and eight of these in a meta-analysis. We show that current dosing regimens are preventing severe deficiency but are not effective at maintaining sufficient vitamin D levels within the Duchenne population. Despite high levels of daily vitamin D supplementation (>1000 International Units), at least 20 % of people with Duchenne remain vitamin D deficient. No significant association between dose and serum vitamin D levels was found (r² = 0.3, p = 0.237). A meta-analysis of mean serum vitamin D levels across eight studies also revealed substantial variability in response to vitamin D supplementation and high heterogeneity (I² = 99.59 %). These data could impact on an individual's risk and severity of osteoporosis and vertebral fractures.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Duchenne muscular dystrophy; Vitamin d; 25-hydroxyvitamin d; 25(OH)d; Calcifediol, Nutrition |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Jul 2024 15:27 |
Last Modified: | 04 Jul 2024 15:27 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.nmd.2023.10.008 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:213817 |