An MYC-Driven Vicious Circuit Is a Targetable Achilles’ Heel in Lymphoma

Abstract

In this issue of Blood Cancer Discovery, Nakanishi et al. uncover a critical role for the elevated activity of the translation initiation factor eIF5A in the malignant growth of MYC-driven lymphoma. eIF5A is posttranslationally modified by hypusination through MYC oncoprotein-mediated hyperactivation of the polyamine–hypusine circuit, which may represent a promising therapeutic target because an enzyme of this circuit that is required for hypusinating eIF5A proved to be essential for lymphoma development.

Metadata

Item Type:	Article
Authors/Creators:	Wilson, E.B. https://orcid.org/0000-0002-0441-728X Klein, U. https://orcid.org/0000-0002-4789-967X
Keywords:	Humans; Neoplasms; Lymphoma; Polyamines; Protein Processing, Post-Translational
Dates:	Published: 5 July 2023 Published (online): 5 July 2023
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Haematology and Immunology The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	10 May 2024 15:04
Last Modified:	10 May 2024 15:04
Status:	Published
Publisher:	American Association for Cancer Research (AACR)
Identification Number:	10.1158/2643-3230.bcd-23-0053
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:212379

CORE (COnnecting REpositories)

An MYC-Driven Vicious Circuit Is a Targetable Achilles’ Heel in Lymphoma

Abstract

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