Li, H. orcid.org/0000-0002-7712-0890, Daniel, A.J. orcid.org/0000-0003-2353-3283, Buchanan, C.E. orcid.org/0000-0003-3010-6079 et al. (10 more authors) (2024) Improvements in between‐vendor MRI harmonization of renal T2 mapping using stimulated echo compensation. Journal of Magnetic Resonance Imaging, 60 (5). pp. 2144-2155. ISSN 1053-1807
Abstract
Background T2 mapping is valuable to evaluate pathophysiology in kidney disease. However, variations in T2 relaxation time measurements across MR scanners and vendors may occur requiring additional correction.
Purpose To harmonize renal T2 measurements between MR vendor platforms, and use an extended-phase-graph-based fitting method (“StimFit”) to correct stimulated echoes and reduce between-vendor variations.
Study Type Prospective.
Subjects 8 healthy “travelling” volunteers (37.5% female, 32 ± 6 years) imaged on four MRI systems across three vendors at four sites, 10 healthy volunteers (50% female, 32 ± 8 years) scanned multiple times on a given MR scanner for repeatability evaluation. ISMRM/NIST system phantom scanned for evaluation of T2 accuracy.
Field Strength/Sequence 3T, multiecho spin-echo sequence.
Assessment T2 images fit using conventional monoexponential fitting and “StimFit.” Mean absolute percentage error (MAPE) of phantom measurements with reference T2 values. Average cortex and medulla T2 values compared between MR vendors, with masks obtained from T2-weighted images and T1 maps. Full-width-at-half-maximum (FWHM) T2 distributions to evaluate local homogeneity of measurements.
Statistical Tests Coefficient of variation (CV), linear mixed-effects model, analysis of variance, student's t-tests, Bland–Altman plots, P-value <0.05 considered statistically significant.
Results In the ISMRM/NIST phantom, “StimFit” reduced the MAPE from 4.9%, 9.1%, 24.4%, and 18.1% for the four sites (three vendors) to 3.3%, 3.0%, 6.6%, and 4.1%, respectively. In vivo, there was a significant difference in kidney T2 measurements between vendors using a monoexponential fit, but not with “StimFit” (P = 0.86 and 0.92, cortex and medulla, respectively). The intervendor CVs of T2 measures were reduced from 8.0% to 2.6% (cortex) and 7.1% to 2.8% (medulla) with StimFit, resulting in no significant differences for the CVs of intravendor repeat acquisitions (P = 0.13 and 0.05). “StimFit” significantly reduced the FWHM of T2 distributions in the cortex and whole kidney.
Data Conclusion Stimulated-echo correction reduces renal T2 variation across MR vendor platforms.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited: https://creativecommons.org/licenses/by/4.0/ |
Keywords: | T2 mapping; extended phase graph; harmonization; kidney; multiecho spin-echo; stimulated echo compensation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/R02264X/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 27 Feb 2024 15:45 |
Last Modified: | 08 Nov 2024 12:48 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/jmri.29282 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209610 |