Han, J., Gao, W. and Harrity, J.P.A. orcid.org/0000-0001-5038-5699 (2024) Pd-Catalyzed [4 + 1] annulation strategy to functionalized 4-methyleneproline derivatives. The Journal of Organic Chemistry, 89 (3). pp. 1552-1555. ISSN 0022-3263
Abstract
A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization of a proline-based derivative.
Metadata
| Item Type: | Article | 
|---|---|
| Authors/Creators: | 
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| Copyright, Publisher and Additional Information: | © 2024 The Authors. Published by American Chemical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | 
| Keywords: | Functionalization; Organic compounds; Pyrrolidines; Reaction products; Sulfur | 
| Dates: | 
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| Institution: | The University of Sheffield | 
| Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) | 
| Depositing User: | Symplectic Sheffield | 
| Date Deposited: | 13 Feb 2024 14:50 | 
| Last Modified: | 13 Feb 2024 14:50 | 
| Published Version: | http://dx.doi.org/10.1021/acs.joc.3c02178 | 
| Status: | Published | 
| Publisher: | American Chemical Society (ACS) | 
| Refereed: | Yes | 
| Identification Number: | 10.1021/acs.joc.3c02178 | 
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209052 | 

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