Hardman, K, Goldman, A and Pliotas, C orcid.org/0000-0002-4309-4858 (2023) Membrane force reception: mechanosensation in GPCRs and tools to address it. Current Opinion in Physiology, 35. 100689. ISSN 2468-8673
Abstract
To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mechanosensitive membrane proteins have evolved across all life kingdoms to sense and respond to forces in the membrane. Bacterial mechanosensitive ion channels provide a blueprint for understanding the fundamental mechanisms that underpin cellular responses to mechanical signals. Recently, the identification of eukaryotic force transducers, which includes membrane proteins other than channels, has led to the recognition of common structural hallmarks and unified biophysical mechanisms that could potentially link these diverse proteins. Accumulating evidence suggests G protein-coupled receptors (GPCRs) are candidates for pressure sensing in mammals. This review summarises the current knowledge on mechanosensitive GPCRs, describes the tools used to assess their mechanosensitivity, and aims to highlight the key characteristics that link these receptors to established mechanosensors.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Published by Elsevier. This is an open access article published under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number BBSRC (Biotechnology & Biological Sciences Research Council) Not Known BBSRC (Biotechnology & Biological Sciences Research Council) BB/W018411/1 BBSRC (Biotechnology & Biological Sciences Research Council) BB/S018069/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Jun 2023 13:57 |
Last Modified: | 18 Oct 2024 14:27 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cophys.2023.100689 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199901 |