Piskunen, P, Latham, R, West, CE orcid.org/0000-0003-1853-0969 et al. (2 more authors) (2022) Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond. iScience, 25 (6). 104389. ISSN 2589-0042
Abstract
Precise genome editing with CRISPR/Cas paves the way for many biochemical, biotechnological, and medical applications, and consequently, it may enable treatment of already known and still-to-be-found genetic diseases. Meanwhile, another rapidly emerging field—structural DNA nanotechnology—provides a customizable and modular platform for accurate positioning of nanoscopic materials, for e.g., biomedical uses. This addressability has just recently been applied in conjunction with the newly developed gene engineering tools to enable impactful, programmable nanotechnological applications. As of yet, self-assembled DNA nanostructures have been mainly employed to enhance and direct the delivery of CRISPR/Cas, but lately the groundwork has also been laid out for other intriguing and complex functions. These recent advances will be described in this perspective.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Funding Information: | Funder Grant number BBSRC (Biotechnology & Biological Sciences Research Council) BB/S020225/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Jun 2022 14:56 |
Last Modified: | 17 Jun 2022 15:40 |
Status: | Published |
Publisher: | Cell Press |
Identification Number: | 10.1016/j.isci.2022.104389 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:187788 |