Denham, JE, Ranner, T orcid.org/0000-0001-7682-3175 and Cohen, N orcid.org/0000-0002-1633-3315 (2018) Signatures of proprioceptive control in Caenorhabditis elegans locomotion. Philosophical Transactions of the Royal Society B: Biological Sciences, 373 (1758). 20180208. ISSN 0962-8436
Abstract
Animal neuromechanics describes the coordinated self-propelled movement of a body, subject to the combined effects of internal neural control and mechanical forces. Here we use a computational model to identify effects of neural and mechanical modulation on undulatory forward locomotion of Caenorhabditis elegans, with a focus on proprioceptively driven neural control. We reveal a fundamental relationship between body elasticity and environmental drag in determining the dynamics of the body and demonstrate the manifestation of this relationship in the context of proprioceptively driven control. By considering characteristics unique to proprioceptive neurons, we predict the signatures of internal gait modulation that contrast with the known signatures of externally or biomechanically modulated gait. We further show that proprioceptive feedback can suppress neuromechanical phase lags during undulatory locomotion, contrasting with well studied advancing phase lags that have long been a signature of centrally generated, feed-forward control.
This article is part of a discussion meeting issue ‘Connectome to behaviour: modelling C. elegans at cellular resolution’.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2018 The Author(s) Published by the Royal Society. All rights reserved. This is an author produced version of a paper published in Philosophical Transactions B: Biological Sciences. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | proprioception; neural control; microswimmers; undulatory locomotion; nematodes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/J004057/1 Leverhulme Trust ECF-2017-591 |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Oct 2018 10:44 |
Last Modified: | 11 Dec 2018 17:32 |
Status: | Published |
Publisher: | The Royal Society |
Identification Number: | 10.1098/rstb.2018.0208 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137534 |