Wiltshire, J.J., Drake, T.M., Uttley, L. orcid.org/0000-0003-4603-9069 et al. (1 more author) (2016) Systematic Review of Trends in the Incidence Rates of Thyroid Cancer. Thyroid, 26 (11). pp. 1541-1552. ISSN 1050-7256
Abstract
BACKGROUND: A large proportion of global increase in thyroid cancer (TC) incidence has been attributed to increased detection of papillary thyroid cancer (PTC). Nonetheless, some reports support a real increase in incidence. We aimed to perform a systematic review to evaluate the changing trends in thyroid cancer incidence and summarise potential risk factors predisposing to this trend. METHODS: English language literature published between 1980 and August 2014 was searched via PubMed (MEDLINE) and OvidSP (EMBASE). Original studies on changes in thyroid cancer incidence in defined geographic areas that described clear methods of case selection and population estimates were included. Data on incidence rates and risk factors were collected. RESULTS: Of 4719 manuscripts, 60 studies were included; 31 from Europe, 13 from North America and the rest from Asia (9), Oceania (4) and South America (3). 53 articles reported a significant increase in incidence (highest was a 10 fold increase in South Korea), 6 reported stable rates and 1 noted a decrease. PTC was the commonest type reported to have increased in incidence (in 10 studies with relevant data). Follicular thyroid cancer (FTC) increased in incidence (in 4 studies); albeit at a lower rate compared to PTC. Data on risk factors was sparse; factors discussed included ionising radiation, iodine deficiency and supplementation. CONCLUSION: This systematic review strongly supports a widespread and persistent increase in thyroid cancer incidence. Evidence for over-detection of PTC as the predominant influence includes increased numbers of smaller size tumours and improved or unchanged survival.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Mary Ann Liebert, Inc.. This is an author produced version of a paper subsequently published in Thyroid. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 22 Nov 2016 15:22 |
Last Modified: | 22 Nov 2016 15:22 |
Published Version: | https://doi.org/10.1089/thy.2016.0100 |
Status: | Published |
Publisher: | Mary Ann Liebert |
Refereed: | Yes |
Identification Number: | 10.1089/thy.2016.0100 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:107910 |