Koppal, S, Warntjes, M, Swann, J et al. (10 more authors) (2017) Quantitative fat and R2* mapping in vivo to measure lipid-rich necrotic core and intraplaque hemorrhage in carotid atherosclerosis. Magnetic Resonance in Medicine, 78 (1). pp. 285-296. ISSN 0740-3194
Abstract
Purpose: The aim of this work was to quantify the extent of lipid-rich necrotic core (LRNC) and intraplaque hemorrhage (IPH) in atherosclerotic plaques. Methods: Patients scheduled for carotid endarterectomy underwent four-point Dixon and T1-weighted magnetic resonance imaging (MRI) at 3 Tesla. Fat and R2* maps were generated from the Dixon sequence at the acquired spatial resolution of 0.60 × 0.60 × 0.70 mm voxel size. MRI and three-dimensional (3D) histology volumes of plaques were registered. The registration matrix was applied to segmentations denoting LRNC and IPH in 3D histology to split plaque volumes in regions with and without LRNC and IPH. Results: Five patients were included. Regarding volumes of LRNC identified by 3D histology, the average fat fraction by MRI was significantly higher inside LRNC than outside: 12.64 ± 0.2737% versus 9.294 ± 0.1762% (mean ± standard error of the mean [SEM]; P < 0.001). The same was true for IPH identified by 3D histology, R2* inside versus outside IPH was: 71.81 ± 1.276 s−1 versus 56.94 ± 0.9095 s−1 (mean ± SEM; P < 0.001). There was a strong correlation between the cumulative fat and the volume of LRNC from 3D histology (R2 = 0.92) as well as between cumulative R2* and IPH (R2 = 0.94). Conclusion: Quantitative mapping of fat and R2* from Dixon MRI reliably quantifies the extent of LRNC and IPH.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 International Society for Magnetic Resonance in Medicine. This is the peer reviewed version of the following article: Koppal, S., Warntjes, M., Swann, J., Dyverfeldt, P., Kihlberg, J., Moreno, R., Magee, D., Roberts, N., Zachrisson, H., Forssell, C., Länne, T., Treanor, D. and de Muinck, E. D. (2016), Quantitative fat and R2* mapping in vivo to measure lipid-rich necrotic core and intraplaque hemorrhage in carotid atherosclerosis. Magn Reson Med., which has been published in final form at http://dx.doi.org/10.1002/mrm.26359. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | atherosclerosis; carotid artery; magnetic resonance imaging; quantitative mapping |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2016 14:45 |
Last Modified: | 14 Aug 2017 07:17 |
Published Version: | http://dx.doi.org/10.1002/mrm.26359 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.26359 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:102223 |