Peers, C, Boyle, JP, Scragg, JL et al. (7 more authors) (2015) Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology, 172 (6). pp. 1546-1556. ISSN 0007-1188
Abstract
Carbon monoxide (CO) is firmly established as an important, physiological signalling molecule as well as a potent toxin. Through its ability to bind metal-containing proteins, it is known to interfere with a number of intracellular signalling pathways, and such actions can account for its physiological and pathological effects. In particular, CO can modulate the intracellular production of reactive oxygen species, NO and cGMP levels, as well as regulate MAPK signalling. In this review, we consider ion channels as more recently discovered effectors of CO signalling. CO is now known to regulate a growing number of different ion channel types, and detailed studies of the underlying mechanisms of action are revealing unexpected findings. For example, there are clear areas of contention surrounding its ability to increase the activity of high conductance, Ca(2+) -sensitive K(+) channels. More recent studies have revealed the ability of CO to inhibit T-type Ca(2+) channels and have unveiled a novel signalling pathway underlying tonic regulation of this channel. It is clear that the investigation of ion channels as effectors of CO signalling is in its infancy, and much more work is required to fully understand both the physiological and the toxic actions of this gas. Only then can its emerging use as a therapeutic tool be fully and safely exploited.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2014, The British Pharmacological Society. This is the peer reviewed version of the following article: Peers, C, Boyle, JP, Scragg, JL, Dallas, ML, Al-Owais, MM, Hettiarachichi, NT, Elies, J, Johnson, E, Gamper, N and Steele, DS (2015) Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology, 172 (6). pp. 1546-1556. ISSN 0007-1188, which has been published in final form at http://dx.doi.org/10.1111/bph.12760. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | Animals; Carbon Monoxide; Cyclic GMP; Humans; Ion Channels; MAP Kinase Signaling System; Nitric Oxide; Reactive Oxygen Species; Signal Transduction |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Cardiovascular Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 May 2016 13:24 |
Last Modified: | 11 Apr 2017 23:40 |
Published Version: | http://dx.doi.org/10.1111/bph.12760 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/bph.12760 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:98718 |