Joda, A, Jin, Z, Haverich, A et al. (2 more authors) (2016) Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress-strain distribution on the aortic valve. Journal of Biomechanics, 49 (12). pp. 2502-2512. ISSN 0021-9290
Abstract
This study developed a realistic 3D FSI computational model of the aortic valve using the fixed-grid method, which was eventually employed to investigate the effect of the leaflet thickness inhomogeneity and leaflet mechanical nonlinearity and anisotropy on the simulation results. The leaflet anisotropy and thickness inhomogeneity were found to significantly affect the valve stress-strain distribution. However, their effect on valve dynamics and fluid flow through the valve were minor. Comparison of the simulation results against in-vivo and in-vitro data indicated good agreement between the computational models and experimental data. The study highlighted the importance of simulating multi-physics phenomena (such as fluid flow and structural deformation), regional leaflet thickness inhomogeneity and anisotropic nonlinear mechanical properties, to accurately predict the stress-strain distribution on the natural aortic valve.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016, Crown Copyright. Published by Elsevier Ltd. This is an author produced version of a paper published in Journal of Biomechanics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Aortic valve; Fluid–structure interaction; Arbitrary Lagrangian Eulerian; Anisotropic material model |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 May 2016 13:42 |
Last Modified: | 14 Apr 2017 03:35 |
Published Version: | https://doi.org/10.1016/j.jbiomech.2016.02.041 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jbiomech.2016.02.041 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:97887 |