Burslem, G, Kyle, H, Breeze, AL orcid.org/0000-0001-9723-3350 et al. (4 more authors) (2016) Towards “Bionic” Proteins: Replacement of Continuous Sequences from HIF-1α with Proteomimetics to Create Functional p300 Binding HIF-1α Mimics. Chemical Communications, 52 (31). pp. 5421-5424. ISSN 1359-7345
Abstract
Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016, The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Crystallography (Leeds) The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > NMR (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Mar 2016 09:58 |
Last Modified: | 11 Apr 2017 12:42 |
Published Version: | http://doi.org/10.1039/C6CC01812B |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C6CC01812B |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96585 |