Moazen, M, Alazmani, A, Rafferty, K et al. (5 more authors) (2016) Intracranial pressure changes during mouse development. Journal of Biomechanics, 49 (1). pp. 123-126. ISSN 0021-9290
Abstract
During early stages of postnatal development, pressure from the growing brain as well as cerebrospinal fluid, i.e. intracranial pressure (ICP), load the calvarial bones. It is likely that such loading contributes to the peripheral bone formation at the sutural edges of calvarial bones, especially shortly after birth when the brain is growing rapidly. The aim of this study was to quantify ICP during mouse development. A custom pressure monitoring system was developed and calibrated. It was then used to measure ICP in a total of seventy three wild type mice at postnatal (P) day 3, 10, 20, 31 and 70. Retrospectively, the sample in each age group with the closest ICP to the average value was scanned using micro-computed tomography to estimate cranial growth. ICP increased from 1.33±0.87 mmHg at P3 to 1.92±0.78 mmHg at P10 and 3.60±1.08 mmHg at P20. In older animals, ICP plateaued at about 4 mmHg. There were statistically significant differences between the ICP at the P3 vs. P20, and P10 vs. P20. In the samples that were scanned, intracranial volume and skull length followed a similar pattern of increase up to P20 and then plateaued at older ages. These data are consistent with the possibility of ICP being a contributing factor to bone formation at the sutures during early stages of development. The data can be further used for development and validation of computational models of skull growth.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Elsevier. This is an author produced version of a paper published in Journal of Biomechanics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Intracranial pressure; Skull; Suture; Biomechanics; Development |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Functional Surfaces (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 May 2016 10:06 |
Last Modified: | 22 Nov 2016 14:23 |
Published Version: | http://dx.doi.org/10.1016/j.jbiomech.2015.11.012 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jbiomech.2015.11.012 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:96557 |