Griffin, M, Seed, PT, Webster, L et al. (14 more authors) (2015) Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height. Ultrasound in Obstetrics and Gynecology, 46 (2). pp. 182-190. ISSN 0960-7692
Abstract
Objectives: To assess the diagnostic accuracy of placental growth factor (PlGF) and ultrasound parameters to predict delivery of a small-for-gestational-age (SGA) infant in women presenting with reduced symphysis–fundus height (SFH). Methods: This was a multicenter prospective observational study recruiting 601 women with a singleton pregnancy and reduced SFH between 24 and 37 weeks' gestation across 11 sites in the UK and Canada. Plasma PlGF concentration < 5th centile, estimated fetal weight (EFW) < 10th centile, umbilical artery Doppler pulsatility index > 95th centile and oligohydramnios (amniotic fluid index < 5 cm) were compared as predictors for a SGA infant < 3rd customized birth-weight centile and adverse perinatal outcome. Test performance statistics were calculated for all parameters in isolation and in combination. Results: Of the 601 women recruited, 592 were analyzed. For predicting delivery of SGA < 3rd centile (n = 78), EFW < 10th centile had 58% sensitivity (95% CI, 46–69%) and 93% negative predictive value (NPV) (95% CI, 90–95%), PlGF had 37% sensitivity (95% CI, 27–49%) and 90% NPV (95% CI, 87–93%); in combination, PlGF and EFW < 10th centile had 69% sensitivity (95% CI, 55–81%) and 93% NPV (95% CI, 89–96%). The equivalent receiver–operating characteristics (ROC) curve areas were 0.79 (95% CI, 0.74–0.84) for EFW < 10th centile, 0.70 (95% CI, 0.63–0.77) for low PlGF and 0.82 (95% CI, 0.77–0.86) in combination. Conclusions: For women presenting with reduced SFH, ultrasound parameters had modest test performance for predicting delivery of SGA < 3rd centile. PlGF performed no better than EFW < 10th centile in determining delivery of a SGA infant.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non commercial and no modifications or adaptations are made. |
Keywords: | estimated fetal weight; fetal growth restriction; placental growth factor; small-for-gestational age |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Obstetrics & Gynaecology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Sep 2016 10:49 |
Last Modified: | 02 Sep 2016 10:49 |
Published Version: | https://dx.doi.org/10.1002/uog.14860 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/uog.14860 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95880 |