McCarthy, R, Orsi, NM, Treanor, D et al. (6 more authors) (2016) Three-dimensional digital reconstruction of human placental villus architecture in normal and complicated pregnancies. European Journal of Obstetrics and Gynecology and Reproductive Biology, 197. pp. 130-135. ISSN 0301-2115
Abstract
Objective: This study aimed to examine the use of digital technology in the three-dimensional reconstruction of human placentas. Study design: Placentas obtained at term elective caesarean section were sampled, formalin-fixed and embedded in paraffin. Two hundred 5 mm consecutive sections were cut from each specimen and the resultant slides stained with haematoxylin and eosin. Slides were then scanned and the digitised images reconstructed using customised software. Results: Three-dimensional reconstructions were successfully achieved in placentas from normal pregnancies and those complicated by pre-eclampsia, growth restriction, and gestational diabetes. Marked morphological differences were readily identifiable, most clearly in the stem villus architecture. Conclusion: This method is an emerging research tool for examining placental histoarchitecture at high resolution and gaining clinically relevant insight into the placental pathology allied to pregnancy complications such as PET, IUGR and GD.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2015, Elsevier Ireland Ltd. All rights reserved. This is an author produced version of paper published in European Journal of Obstetrics & Gynecology and Reproductive Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | 3D reconstruction; Placenta; Stem villi; Pre-eclampsia; Intrauterine growth restriction |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) > Artificial Intelligence & Biological Systems (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Obstetrics & Gynaecology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Apr 2016 08:42 |
Last Modified: | 31 Dec 2016 07:18 |
Published Version: | http://dx.doi.org/10.1016/j.ejogrb.2015.12.015 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ejogrb.2015.12.015 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:95875 |