Hyde, PJ, Tipper, JL, Fisher, J et al. (1 more author) (2015) Wear and biological effects of a semi-constrained total disc replacement subject to modified ISO standard test conditions. Journal of the Mechanical Behavior of Biomedical Materials, 44. pp. 43-52. ISSN 1751-6161
Abstract
Development of pre-clinical testing methodologies is an important goal for improving prediction of artificial replacement joint performance and for guiding future device design. Total disc replacement wear and the potential for osteolysis is a growing concern, therefore a parametric study on the effects on wear of altered kinematics and loading was undertaken. A standard ISO testing protocol was modified in order to study the wear behaviour of lumbar total disc replacements when subject to low cross shear input kinematics, reduced axial loading and smaller flexion–extension magnitude. Volumetric wear, bearing surface topography, and wear debris biological reactivity were assessed. The ISO standard results were expected, however, the very low cross shear test produced a level of wear approximately two orders of magnitude higher than that reported for zero cross shear motions on UHMWPE bearings. When the osteolytic potential of the wear particles was calculated, all total disc replacement simulations had lower predicted osteolytic potential compared to total hip replacements, as a consequence of the generally lower wear rates found.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2015, published by Elsevier Ltd. This is an author produced version of a paper published in the Journal of the Mechanical Behavior of Biomedical Materials. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | TDR; Arthroplasty; Disc; Osteolyis; Wear; Simulation; Fusion |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Apr 2016 10:58 |
Last Modified: | 17 Jan 2018 19:34 |
Published Version: | http://dx.doi.org/10.1016/j.jmbbm.2014.12.001 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jmbbm.2014.12.001 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94565 |