Collinson, K, Murray, MJ, Orsi, NM et al. (5 more authors) (2014) Age-related biological features of germ cell tumors. Genes, Chromosomes and Cancer, 53 (3). pp. 215-227. ISSN 1045-2257
Abstract
Germ cell tumors (GCTs) are rare but clinically and pathologically diverse tumors that occur in an extensive range of age groups, from children to older adults and which include both seminomatous and nonseminomatous tumors. Current clinical management for both male and female teenagers and young adults (TYAs) with GCTs remains inconsistent, alternating between pediatric and adult multidisciplinary oncology teams, based on locally defined age cutoffs. Therefore, we reviewed available literature to determine the biological similarities and differences between GCTs in young children (0–12 years), TYAs (13–24 years), and older adults (>24 years). GCTs arising in pediatric and adult populations in general showed marked molecular biological differences within identical histological subtypes, whereas there was a distinct paucity of available data for GCTs in the TYA population. These findings highlight that clinical management based simply on chronological age may be inappropriate for TYA and suggests that the optimal future management of GCTs should consider specific molecular biological factors in addition to clinical parameters in the context of patient-specific age group rather than medical specialty.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2013 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Collinson, K., Murray, M. J., Orsi, N. M., Cummings, M., Shipley, J., Joffe, J. K., Coleman, N. and Stark, D. (2014), Age-related biological features of germ cell tumors. Genes, Chromosomes and Cancer, 53: 215–227, which has been published in final form at http://dx.doi.org/10.1002/gcc.22131. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Obstetrics & Gynaecology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Jun 2016 12:01 |
Last Modified: | 16 Jan 2018 11:42 |
Published Version: | http://dx.doi.org/10.1002/gcc.22131 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/gcc.22131 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94552 |