Holub, O, Lopez, A, Borse, V et al. (4 more authors) (2015) Biomechanics of low-modulus and standard acrylic bone cements in simulated vertebroplasty: A human ex vivo study. Journal of Biomechanics, 48 (12). pp. 3258-3266. ISSN 0021-9290
Abstract
The high stiffness of bone cements used in vertebroplasty has been hypothesized to contribute to the propensity of adjacent vertebral fractures after treatment. Therefore, new low-modulus cements have been developed; however, there are currently no studies assessing the biomechanical aspects of vertebroplasty with these cements in an ex vivo non-prophylactic model. In this study, we induced wedge fractures through eccentric uniaxial compression to single whole-vertebrae, before and after augmentation with either standard or low modulus cement. Compressive strength and stiffness of individual vertebrae were measured, on 19 samples from metastatic spines and 20 samples from elderly, osteopenic spines. While both cement types increased the strength of both the metastatic (+34% and +63% for standard and low-modulus cement, respectively) and the elderly vertebrae (+ 303% and +113%, respectively), none of them restored the initial stiffness of metastatic specimens (-51% and -46%, respectively). Furthermore, low-modulus cement gave a lower total stiffness (-13%) of elderly specimens whereas standard cement increased it above initial levels (+17%). Results show that vertebroplasty with low-modulus cement could provide restoration of the initial stiffness while increasing the strength of fractured elderly vertebrae and hence represent a treatment modality which is closer to pre augmented behaviour. Also, this study indicates that stiffness-modified cement needs to be optimized for patient/pathology specific treatment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2015 Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Journal of Biomechanics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Vertebroplasty; Low-modulus cement; Adjacent vertebral fracture; Osteoporosis; Metastasis; Compression fracture |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Jan 2016 15:06 |
Last Modified: | 16 Nov 2016 08:54 |
Published Version: | http://dx.doi.org/10.1016/j.jbiomech.2015.06.026 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jbiomech.2015.06.026 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:94305 |