Ghorani, B, Russell, SJ orcid.org/0000-0003-0339-9611, Hebden, AJ et al. (1 more author) (2017) Single Step Assembly of Biomolecule-Loaded Sub-Micron Polysulfone Fibres. Textile Research Journal, 87 (3). pp. 340-350. ISSN 0040-5175
Abstract
Enrichment of chemically resistant hydrophobic polymers with polar biomolecules is relevant to the production of fibre-based drug delivery devices, adsorptive filtration media, as well as fibres for selective molecular recognition of antibodies, enzymes and nucleic acids. Polysulphone (PSU) is an amorphous polymer possessing high-strength, rigidity and excellent thermal stability. The preparation of PSU spinning solutions requires lengthy dissolution times at elevated temperature that tends to degrade commixed polar biomolecules. Using the highly polar metabolite creatinine, as a model system, a variety of co-solvents was evaluated for electrospinning commixed solutions of PSU and creatinine at room temperature. Selection of solvent systems was informed by Hansen solubility parameters. A binary system of N, N-dimethylacetamide (DMAc): methanol (4:1) was not found to be a suitable solvent because of the need for elevated temperature (80°C) to facilitate dissolution, and a binary solvent system of N, N-dimethylformamide (DMF):dimethyl sulfoxide (DMSO) (3:2) resulted in nozzle blockage during spinning. A binary system of DMAc:DMSO (13:7) enabled spinning of PSU with creatinine at ambient temperature and sub-micron fibres substantially free of beads were produced continuously via electrospinning, yielding fibre diameters in the range 540-890 nm. The presence of creatinine was confirmed by High Performance Liquid Chromatography (HPLC) and fibre morphology was examined by Scanning Electron Microscopy (SEM).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2016. This is an author produced version of a paper published in the Textile Research Journal. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Electrospinning; Nanofibres; Polysulfone; Biomolecule; Creatinine |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Jan 2016 11:25 |
Last Modified: | 26 Jan 2017 16:53 |
Published Version: | https://doi.org/10.1177/0040517516629148 |
Status: | Published |
Publisher: | SAGE Publications |
Identification Number: | 10.1177/0040517516629148 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:93121 |